New study challenges claims that low vitamin D causes type 2 diabetes

Date: Oct-01-2014 A new study from the University of Cambridge in the UK challenges findings of earlier

research that concludes having higher levels of circulating vitamin D might prevent type 2

diabetes.

These earlier observational studies raised suggestions that low vitamin D contributes to the

development of type 2 diabetes. But because they were not designed to investigate cause and effect,

they could not prove it: they could only establish a link.

Now a large genetic study published in The Lancet Diabetes and Endocrinology journal,

concludes there is no evidence that a person's low level of vitamin D leads them to develop type 2

diabetes.

Senior author Dr. Nita Forouhi, leader of the Nutritional Epidemiology program at Cambridge's

Medical Research Council (MRC) Epidemiology Unit, says:

"Observational studies that show a strong and consistent higher risk of type 2 diabetes with

lower levels of vitamin D may do so because they have thus far not been able to adequately control

for distorting or confounding factors, such as physical activity levels, that may be related both

to vitamin D levels and to the risk of type 2 diabetes."

Using data from several studies covering thousands of people of European descent, Dr. Forouhi

and colleagues investigated the link between levels of vitamin D and risk of developing diabetes

by examining the genes that control blood levels of vitamin D.

The authors also used circulating 25-hydroxyvitamin D levels - considered the best indicator of

vitamin D status - as the measure for vitamin D. Insufficiency was defined as having blood levels

of 25-hydroxyvitamin D under 50 nmol/L.

No evidence that low vitamin D causes type 2 diabetes

The researchers found no evidence of a link between the risk of developing type 2 diabetes and the

different gene variants that control blood levels of vitamin D.

They also found no links between varying levels of vitamin D and several features of type 2

diabetes, such as glucose and glycated hemoglobin, and neither did they find evidence that low

vitamin D causes the disease.

Dr. Forouhi says their results echo those of randomized controlled trials - the classic way to

test cause and effect links - which have generally concluded taking vitamin D supplements does not

stop people developing type 2 diabetes.

"Our findings suggest that interventions to reduce the risk of type 2 diabetes by increasing

concentrations of vitamin D are not currently justified," she notes.

Research must continue, especially with longer-term trials say experts

However, "we are far from done with this topic," says Dr. Forouhi who calls for better clinical

trials and observational studies to measure more precisely the factors that might link vitamin D to

disease.

The researchers found no evidence of a link between the risk of developing type 2 diabetes and the different gene variants that control blood levels of vitamin D.

"Until then, we need to be cautious about vitamin D's potential role in the prevention of type 2

diabetes and stick to things that are proven to work - diet and exercise," she urges.

One of the reasons to persist with research on the link between vitamin D and diabetes is that

there appears to be a plausible biological explanation. The active form of

the vitamin interacts with proteins in the insulin-producing beta cells in the pancreas. Also,

people with diabetes tend to have low blood levels of vitamin D.

Another expert commenting in a linked article says the new findings need to be interpreted

carefully. He also makes the point that despite the fact results of short-term studies do not appear to offer much hope, we need to await the results of longer-term trials before drawing final conclusions. However:

"The sky is becoming rather clouded for vitamin D in the context of preventing type 2 diabetes,"

says Dr. Brian Buijsse, of the German Institute of Human Nutrition in Potsdam-Rehbruecke in

Germany.

This news follows reports of another UK study that found contrary to some previous claims, taking vitamin D supplements does not prevent heart attack or

stroke.

Written by Catharine Paddock PhD

Not to be reproduced without permission.

Courtesy: Medical News Today Note: Any medical information available in this news section is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional.