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Symptoms Of Burnout Suffered By Many US Oncologists Despite High Career Satisfaction
Date: Jun-04-2013Even though a majority of U.S. oncologists report satisfaction with their careers, many say they have experienced at least one symptom of burnout, a Mayo Clinic-led study has found. The study was released during the American Society of Clinical Oncology's annual meeting in Chicago. "Oncology can be a tremendously rewarding area of medicine, but caring for patients with cancer is also demanding and stressful," says lead author Tait Shanafelt, M.D., a Mayo Clinic hematologist/oncologist...
No Benefit Offered By Bevacizumab For Newly Diagnosed Glioblastoma
Date: Jun-04-2013The angiogenesis inhibitor bevacizumab (Avastin) failed to increase overall survival (OS) or statistically significant progression-free survival (PFS) for glioblastoma patients in the frontline setting, according to research led by researchers at The University of Texas MD Anderson Cancer Center. The study was presented at the American Society of Clinical Oncology 2013 Annual Meeting by Mark Gilbert, M.D., professor in MD Anderson's Department of Neuro-Oncology. Glioblastoma is both the most common and lethal form of brain cancer...
Lung Cancer Outcomes Boosted By Targeted Therapy
Date: Jun-04-2013Thousands of patients with an advanced form of lung cancer that carries a specific dysfunctional gene are likely to fare better if treated with a targeted therapy than with traditional chemotherapy, report Dana-Farber Cancer Institute researchers and a team of international collaborators. In a trial involving patients with non-small cell lung cancer (NSCLC) whose tumor cells harbored an abnormal ALK gene, those who received the oral drug crizotinib, which acts directly on ALK, went a median time of 7...
Glioblastoma Patients Treated With Bevacizumab Experience Reduced Cognitive Function And Quality Of Life
Date: Jun-04-2013Many glioblastoma patients treated with bevacizumab (Avastin®) have significant deterioration in neurocognitive function, symptoms and quality of life. Not only that, the changes often predict treatment outcomes, according to new research from The University of Texas MD Anderson Cancer Center. The findings from the large national multi-center Phase III trial, RTOG 0825, were presented at the annual meeting of the American Society of Clinical Oncology. Glioblastoma is the most frequent and aggressive type of brain tumor...
Revascularization Procedures Saving Limbs Of More Peripheral Arterial Disease Patients
Date: Jun-04-2013Peripheral arterial disease is a common circulation problem in which reduced blood flow can lead to complications that jeopardize the limbs, possibly even requiring amputation. Procedures known as have reduced the need for amputations 40 percent over two decades, Mayo Clinic research shows. The findings were among several studies presented at the Society for Vascular Surgery annual meeting in San Francisco...
Flames Can Change The Sound Of A Firefighters' Personal Safety Alarm
Date: Jun-04-2013The PASS, short for "Personal Alert Safety System," has been used by firefighters for thirty years to help track members of their team who might be injured and need assistance to escape a fire. Though the alarm has saved many lives, there are cases in which the device is working correctly but is not heard or not recognized. In one recent incident report from 2010, firefighters inside a burning building either did not hear or heard and then stopped hearing an alarm that was easily audible from outside the building...
Tobacco Harm Reduction Affected By GP's Belief That Nicotine Is A Harmful Cigarette-Smoke Component
Date: Jun-04-2013A survey of GPs (general practitioners) in the UK and Sweden revealed that some hold the view that one of the greatest health risks from smoking is nicotine. This belief likely influences health advice to smokers when considering whether to recommend the use of alternative nicotine products. Nicotine is the addictive component of tobacco smoke, but unlike some other constituents of tobacco smoke, it is not carcinogenic and according to the UK Royal College of Physicians, 'medicinal nicotine is a very safe drug...
Personalized Strategies For Pretesting Cervical Tumors
Date: Jun-04-2013Doctors at Washington University School of Medicine in St. Louis have shown that testing cervical tumors before treatment for vulnerability to chemotherapy predicts whether patients will do well or poorly with standard treatment. The study supports the future possibility of personalized medicine for cervical cancer, a tumor normally addressed with a one-size-fits-all approach. "Even though this is a small study, its strength is that it links a lab test of the tumor's chemotherapy response to survival outcomes for the patients," said Julie K...
Body's Response To Intestinal Infections Controlled By Circadian Rhythms
Date: Jun-04-2013Circadian rhythms can boost the body's ability to fight intestinal bacterial infections, UC Irvine researchers have found. This suggests that targeted treatments may be particularly effective for pathogens such as salmonella that prompt a strong immune system response governed by circadian genes. It also helps explain why disruptions in the regular day-night pattern - as experienced by, say, night-shift workers or frequent fliers - may raise susceptibility to infectious diseases...
Lead Exposure May Trigger Schizophrenia
Date: Jun-04-2013Mice engineered with a human gene for schizophrenia and exposed to lead during early life exhibited behaviors and structural changes in their brains consistent with schizophrenia. Scientists at Columbia University's Mailman School of Public Health and the Johns Hopkins University School of Medicine say their findings suggest a synergistic effect between lead exposure and a genetic risk factor, and open an avenue to better understanding the complex gene-environment interactions that put people at risk for schizophrenia and other mental disorders...
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