A Cellular Adhesion Protein Protects Against Inflammation

Date: Feb-05-2013Cellular inflammation is mediated by a group of proteins known as the inflammasome.

In this issue of the Journal of Clinical Investigation, Ziad Mallat and colleagues at Addenbrooke's Hospital in Cambridge, England, identified a protein, MFGE8, that blocks inflammasome activity.

Using a mouse model of stroke, Mallat and colleagues determined that expression of MFGE8 inhibited the production of pro-inflammatory products and limited the area of injury after stroke.

These results identify MFGE8 as an important regulator of inflammation that could potentially serve as a useful therapeutic target in inflammatory disease.

TITLE:
MFGE8 inhibits inflammasome-induced IL-1β production and limits post-ischemic cerebral injury

View this article at: http://www.jci.org/articles/view/65167?key=9c368b2173b91a4a0e01
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