New Freezing Procedure Increases Availability Of Cord Blood Stem Cell Transplants For Patients

Date: Feb-11-2013A large enough number of stem cells are needed to ensure the success of a cord blood
transplant. However, the quantity of stem cells isolated from umbilical cord blood is not
always sufficient to meet that requirement. Researchers from the Etablissement Francais
du Sang, Aquitaine-Limousin (France) have established a method to multiply cord blood stem
cells to required quantity levels.

In the current study Dr. Ivanovic and co-workers
(Etablissement Français du Sang Aquitaine-Limousin) and a team of Cryo-Save researchers
have demonstrated that these cultured stem cells can be frozen and thawed without
negatively affecting the quality of the stem cells. An important step towards successful
stem cell transplants in patients for whom too few stem cells are available.

Umbilical cord blood stem cells for cell transplants

The umbilical cord blood is a storehouse of stem cells. These are special because they
can develop into many kinds of different human cells including blood, nerve and skin
cells. This potentiality is already being put to use in the treatment of various grave
illnesses, including certain types of leukemia.

Stem cell therapy demands sufficient quantities of stem cells

In some cases the number of stem cells that is isolated from the umbilical cord is too
small for a transplant. A double cord blood unit transplantation and combination treatment
of umbilical cord and bone marrow cells offers possible solutions. Isolating bone marrow
stem cells is, however, a very painful procedure for the patient and finding a proper
donor might prove difficult.

Multiplying, freezing and thawing high-quality stem cells

Researchers at the Etablissement Français du Sang, Aquitaine-Limousin (France) are
now able to multiply isolated stem cells until the required quantity is obtained. This
means that an optimal freeze/thaw procedure is essential if the multiplied cells are to be
administered to a patient at a later stage.

Scientists at Cryo-Save collaborated on a study to determine under what specific
conditions multiplied hematopoietic stem cells should be frozen so that they may be
successfully recovered after thawing and used in a transplant later on with a guarantee of
quality and high chance of engraftment.

Newly developed cryopreservation technique
performed better in recovery of expanded stem cells when comparing to standard
cryoprotectants. The expansion/freeze/thaw procedure results in sufficient umbilical cord
blood stem cells for a single cell transplant increasing cord blood availability for
patients and reducing the cost of treatment when double unit transplantation is
considered.

Currently ongoing clinical testing of this procedure is the next major step towards
development of standard protocol for cord blood expansion.

The research team at Cryo-Save remains committed to finding the optimal conditions for
using cord blood stem cells in stem cell therapy with a view to curing patients.

Courtesy: Medical News Today Note: Any medical information available in this news section is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional.