In A Mouse Model Of Polycystic Kidney Disease, Vitamin B3 Blocks Cyst Formation

Date: Jun-19-2013Autosomal dominant polycystic kidney disease (ADPKD) is an inherited systemic disorder caused by mutations in PKD1 or PKD2 that predominately affects the kidneys and is characterized by the formation of cysts in the kidneys and other organs.

Xiaogang Li and colleagues at the University of Kansas Medical Centr used a mouse model of ADPKD to explore the role of the protein sirtuin 1 in cyst formation. They found that inhibition of sirtuin 1 activity using vitamin B3 can reduced cyst formation in the kidneys of ADPKD mice. These findings suggest that therapeutics targeting sirtuin 1 could potentially be used to treat ADPKD.

TITLE: Sirtuin 1 inhibition delays cyst formation in autosomal dominant polycystic kidney disease

View this article at: http://www.jci.org/articles/view/64401?key=c91bce99794e2ba22c42
Courtesy: Medical News Today Note: Any medical information available in this news section is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional.