Neuronal hypoxic tolerance increased by overexpression of cytoglobin gene

Date: Sep-18-2013Cytoglobin is a temporary oxygen reservoir, which might provide a minimal, but continuous supply of intracellular oxygen during ischemic and anoxic conditions.

A research team from China Medical University was the first to use a plasmid carrying green fluorescent protein as the carrier to construct recombinant plasmids expressing cytoglobin by genetic engineering methods. Then, the recombinant plasmid was transfected into SH-SY5Y cells. Xiuling Yu and colleagues found that overexpression of cytoglobin could protect SH-SY5Y cells against cobalt chloride-induced hypoxia.

The researchers investigate the neuroprotective ways from the perspective of in vitro genetic engineering, thereby providing reliable evidence for gene therapy of hypoxic-ischemic neurological diseases. The relevant findings were published in Neural Regeneration Research (Vol. 8, No. 23, 2013).

Yu XL, Gao DW. Overexpression of the cytoglobin gene inhibits hypoxic injury to SH-SY5Y neuroblastoma cells. Neural Regen Res. 2013;8(23):2198-2203.

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