Aggressive new HIV strain leads to AIDS more quickly

Date: Nov-29-2013New research from Lund University in Sweden suggests that a new aggressive strain of HIV

develops more rapidly into AIDS than other current strains.

From first infection with HIV to developing AIDS can be as short as 5 years - the shortest

known for HIV-1 types - say the researchers.

The new strain is a "recombinant" virus - a cross of two viruses that meet in an infected

person.

The two viruses, known as 02AG and A3, are the two most common strains in Guinea-Bissau,

West Africa. The recombinant strain is called A3/02 and so far has only been seen in the region.

There are over 60 different epidemic strains of HIV-1 in the world. But usually different regions

are dominated by only one or two of them.

However, if two strains infect the same person, they can combine to form a cross between the two

- known as a recombinant.

The researchers report their findings in the Journal of Infectious Diseases, and first author Angelica Palm, who is working toward a doctorate at Lund, says:

"Recombinants seem to be more vigorous and more aggressive than the strains from which they

developed."

The new strain, A3/02, has previously been described by one of the other authors, Dr. Joakim

Esbjörnsson.

Recombinant strains of HIV are spreading rapidly around the world

Although it has so far only been seen in West Africa, other studies have shown recombinants are

spreading more rapidly around the world.

Parts of the world, such as the US and Europe where there are high levels of immigration, are

seeing increasingly mixed and complex variants of HIV. This is quite different to the early years

of the HIV epidemic, when there were few dominant strains and no recombinants.

The researchers suggest we need to be wary of the rise in recombinants, as senior author Patrik

Medstrand, professor of Clinical Virology at Lund University, explains:

"HIV is an extremely dynamic and variable virus. New subtypes and recombinant forms of HIV-1 have

been introduced to our part of the world, and it is highly likely that there are a large number of

circulating recombinants of which we know little or nothing. We therefore need to be aware of how

the HIV-1 epidemic changes over time."

The researchers drew their conclusions after looking at data gleaned in a Lund University project

that carried out a long-term follow-up of HIV-infected people in Guinea-Bissau.

The team is now planning to spend more time looking at recombinant viruses and their occurrence

among HIV-infected people in Europe.

In 2012, scientists at the University of California, Los Angeles (UCLA), reported finding a clue

as to why some people infected with

HIV appear to remain healthy for 20 years or more, while others progress to AIDS much

faster.

They found that "slow progressors" were more likely to carry a gene variant that causes the

immune system to attack a particular section of the HIV protein.

Written by Catharine Paddock PhD

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