Protein in fish skin may help wounds heal safely

Date: Feb-12-2015 Applying collagen to wounds can help skin heal faster, but when the collagen

comes from animals such as cows and pigs, it brings with it a small risk of disease. Now,

a new study suggests collagen from tilapia fish - an increasingly popular seafood in

the US - may offer a safer alternative.

Collagen accounts for a quarter of all

the protein in our bodies.

Tian Zhou, from the Shanghai Jiaotong University School of Medicine in China, and colleagues

report their findings in the journal ACS Applied Materials and

Interfaces.

Collagen is a structural protein that accounts for around a quarter of all

the protein in our bodies. It is the major constituent of connective tissues,

tendons, skin, bones, cartilage, blood vessels and membranes.

Collagen is the "warp and woof" that holds tissue together in different forms -

from molecular cables that strengthen tendon fibers to resilient sheets that support

the skin and internal organs.

And when you add mineral crystals to collagen, you have the basic material for

making bones and teeth.

Wound dressings made from collagen have several advantages - they keep out

bacteria, they are easy to apply, they are natural, hypo-allergenic and pain-free.

However, because they are made from collagen taken from cows and pigs

(bovine and porcine collagen), collagen wound dressings also carry a slight risk of

transferring conditions such as foot and mouth disease.

Fish collagen would not pose such a disease risk - but does it perform well as a

wound dressing? The team behind the new study decided to find out.

Rats with the fish collagen wound dressings healed faster

For the study, they made nanofibers from the collagen of tilapia fish and used them

to cover skin wounds on rats.

The team found rats with the nanofiber dressing healed faster than those without

it.

In lab tests, the researchers found various ways in which the

fish collagen nanofibers "could promote the viabilities" of human skin cells, including stimulating genes that

code for various binding proteins and growth factors.

Cell tests also showed the fish collagen was unlikely to cause an immune

reaction - an important requirement for a wound dressing.

The team suggests the tilapia collagen should now be tested and developed for

clinical use.

Tilapia is a tropical, freshwater fish that thrives naturally in the very warm

waters of Africa and the Middle East.

Tilapia is an increasingly popular seafood in the US, where it is grown in closed

tank systems. However, most tilapia sold in the US is imported from Latin America

and Asia, where the fish are raised in outdoor freshwater farms.

In Australia, tilapia is causing serious negative impact in some waterways. In Queensland, the authorities have declared tilapia a

noxious fish, and there are stiff penalties for releasing the fish alive or dead

into waterways there.

The National Natural Science Foundation of China funded the study.

In May 2014, Medical News Today learned how new research conducted at

the University of Manchester Healing Foundation Centre in the UK showed wound healing is affected by bacteria living on

skin. The researchers said it may be possible to could swab a wound and look at the profile

of bacteria to see if it is likely to heal quickly or persist. Such information

could also be useful in deciding how to treat the wound.

Written by Catharine Paddock PhD

Courtesy: Medical News Today Note: Any medical information available in this news section is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional.