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Clues to the origin of autism
Date: Nov-25-2013Finding major new clues to the origins of autism, a Yale-led team of researchers has pinpointed which cell types and regions of the developing human brain are affected by gene mutations linked to autism. They report their findings in the journal Cell.Analyzing massive amounts of gene expression data generated by the BrainSpan project, the team identified common neural circuits affected by autism-risk genes and when, where, and in what cell types those genes exert their effects on the developing human brain and lead to autism spectrum disorders.
Brains feel and think alike when playing computer games
Date: Nov-25-2013It's well known that people who communicate face-to-face will start to imitate each other. People adopt each other's poses and gestures, much like infectious yawning. What is less known is that the very physiology of interacting people shows a type of mimicry - which we call synchrony or linkage, explains Michiel Sovijärvi-Spapé.In the study, test participants play a computer game called Hedgewars, in which they manage their own team of animated hedgehogs and in turns shoot the opposing team with ballistic artillery. The goal is to destroy the opposing team's hedgehogs.
A roadblock to nerve cell transplantation decoded
Date: Nov-25-2013A vision is to implant nerve precursor cells in the diseased brains of patients with Parkinson's and Huntington's diseases, whereby these cells are to assume the function of the cells that have died off. However, the implanted nerve cells frequently do not migrate as hoped, rather they hardly move from the site. Scientists at the Institute for Reconstructive Neurobiology at Bonn University have now discovered an important cause of this: Attractants secreted by the precursor cells prevent the maturing nerve cells from migrating into the brain.
Insight into how 'jumping gene' gets around
Date: Nov-25-2013Using a new method to catch elusive "jumping genes" in the act, researchers have found two human proteins that are used by one type of DNA to replicate itself and move from place to place. The discovery, described in the journal Cell, breaks new ground, they say, in understanding the arms race between a jumping gene driven to colonize new areas of the human genome and cells working to limit the risk posed by such volatile bits of DNA.
Insight into how 'jumping gene' gets around
Date: Nov-25-2013Using a new method to catch elusive "jumping genes" in the act, researchers have found two human proteins that are used by one type of DNA to replicate itself and move from place to place. The discovery, described in the journal Cell, breaks new ground, they say, in understanding the arms race between a jumping gene driven to colonize new areas of the human genome and cells working to limit the risk posed by such volatile bits of DNA.
Findings suggest anticancer drugs may have implications for oncology, diabetes drug development
Date: Nov-25-2013Drugs that inhibit the activity of enzymes called histone deacetylases (HDACs) are being widely developed for treating cancer and other diseases, with two already on the market. Researchers at the Perelman School of Medicine, University of Pennsylvania, show that a major HDAC still functions in mice even when its enzyme activity is abolished, suggesting that the beneficial effects of HDAC inhibitors may not actually be through inhibiting HDAC activity, and thus warranting the reassessment of the molecular targets of this class of drugs.
Findings suggest anticancer drugs may have implications for oncology, diabetes drug development
Date: Nov-25-2013Drugs that inhibit the activity of enzymes called histone deacetylases (HDACs) are being widely developed for treating cancer and other diseases, with two already on the market. Researchers at the Perelman School of Medicine, University of Pennsylvania, show that a major HDAC still functions in mice even when its enzyme activity is abolished, suggesting that the beneficial effects of HDAC inhibitors may not actually be through inhibiting HDAC activity, and thus warranting the reassessment of the molecular targets of this class of drugs.
New ostomy care resource developed
Date: Nov-25-2013Nurses caring for ostomy patients will now be equipped with an essential new tool that provides them with the first comprehensive guide to optimize ostomy management and enhance patient safety. Janice Beitz, a professor at the Rutgers School of Nursing - Camden, was part of a research team that developed the ostomy algorithm, a step-by-step aid that allows nurses to properly assess ostomy patients and their needs. "The majority of ostomy care is provided by non-specialized clinicians or caregivers and family members who do not have ostomy care expertise," Beitz says.
Inflammation protein linked to obesity in women
Date: Nov-25-2013Scientists have discovered that a protein usually linked to inflammation may be involved in the development of obesity in women. This is a according to a new study published in the journal BMC Endocrine Disorders.The team of researchers, led by Silvia Lorente-Cebrißn and Ingrid Dahlman of the Karolinska Institutet in Sweden, say a better understanding of the function of this protein, called allograft inflammatory factor 1 (AIF-1), could give researchers an insight into how obesity progresses.According to the Centers for Disease Control and Prevention (CDC), around 56.
Inflammation protein linked to obesity in women
Date: Nov-25-2013Scientists have discovered that a protein usually linked to inflammation may be involved in the development of obesity in women. This is a according to a new study published in the journal BMC Endocrine Disorders.The team of researchers, led by Silvia Lorente-Cebrißn and Ingrid Dahlman of the Karolinska Institutet in Sweden, say a better understanding of the function of this protein, called allograft inflammatory factor 1 (AIF-1), could give researchers an insight into how obesity progresses.According to the Centers for Disease Control and Prevention (CDC), around 56.
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