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Cornerstone pharmaceuticals receives FDA orphan drug designation of CPI-613 for treatment of myelodysplastic syndrome
Date: Oct-07-2013Cornerstone Pharmaceuticals, Inc., a leader in the growing field of cancer metabolism-based therapeutics, has announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation to CPI-613, the Company's lead Altered Energy Metabolism Directed (AEMD) drug candidate, for the treatment of myelodysplastic syndrome (MDS). MDS is a form of cancer that occurs when the blood-forming cells in the bone marrow are damaged, which leads to low numbers of one or more type of blood cells...
Those briefly ostracized, recover more quickly if they previously were given focused attention training
Date: Oct-07-2013When people are briefly ostracized, they feel distress that may linger for some time, however, they recover more quickly from the experience if they are better prepared mentally to focus on something else, shows a new study from Purdue University and the University of Lille, France. "When confronted with short episodes of ostracism, the best way to cope is to not ruminate on the experience but to focus on the present rather than relive the past," said Kipling D. Williams, Purdue professor of psychological sciences, who has studied ostracism for 20 years...
Changing bacterial mix could lead to painful sex after menopause
Date: Oct-07-2013The mix of bacteria in the vagina changes as women go through menopause. And a certain mix is typical after menopause in women who have vulvovaginal atrophy (VVA), a common cause of vaginal dryness and sexual pain, finds a team at Johns Hopkins and the University of Maryland. They suspect these bacteria may play a role in causing VVA and that personalized probiotics or other ways to manage the bacterial mix might prevent or treat VVA in the future. Their study was published online today in Menopause, the journal of The North American Menopause Society...
An end to the deadly disease of sleeping sickness?
Date: Oct-07-2013A tag team of two bacteria, one of them genetically modified, has a good chance to reduce or even eliminate the deadly disease African trypanosomiasis, or sleeping sickness, researchers at Oregon State University conclude in a recent mathematical modeling study. African trypanosomiasis, caused by a parasite carried by the tsetse fly, infects 30,000 people in sub-Saharan Africa each year and is almost always fatal without treatment. In a 2008 epidemic, 48,000 people died...
Risk for post-stroke dangers flagged by new data-driven machine learning method
Date: Oct-07-2013A team of experts in neurocritical care, engineering, and informatics, with the Perelman School of Medicine at the University of Pennsylvania, have devised a new way to detect which stroke patients may be at risk of a serious adverse event following a ruptured brain aneurysm. This new, data-driven machine learning model, involves an algorithm for computers to combine results from various uninvasive tests to predict a secondary event. Preliminary results were released at the Neurocritical Care Society Annual Meeting in Philadelphia...
Reducing radiation exposure in children needing repeat brain scans
Date: Oct-07-2013A team of pediatric neurosurgeons and neuroradiologists at the Johns Hopkins Children's Center has developed a way to minimize dangerous radiation exposure in children with a condition that requires repeat CT scans of the brain. The experts say they reduced exposure without sacrificing the diagnostic accuracy of the images or compromising treatment decisions. The approach, described ahead of print in a report in the Journal of Neurosurgery, calls for using fewer X-ray snapshots or "slices" of the brain taken by CT scanners - seven instead of the standard 32 to 40 slices...
Risk for abdominal aortic aneurysms predicted by molecular imaging
Date: Oct-07-2013Several newly identified markers could provide valuable insight to predict the risk of rupture abdominal aortic aneurysms (AAA), according to new research published in the October issue of The Journal of Nuclear Medicine. Imaging with positron emission tomography/computed tomography (PET/CT) has shown that dense white blood cells in the outermost connective tissue in the vascular wall, increased C-reactive protein and a loss of smooth muscle cells in the middle layer of the vascular wall are all factors that may indicate future AAA rupture...
Global warming may boost fishes' metabolism and accumulation of toxic metal
Date: Oct-07-2013Rising ocean surface temperatures caused by climate change could make fish accumulate more mercury, increasing the health risk to people who eat seafood, Dartmouth researchers and their colleagues report in a study in the journal PLOS ONE. Until now, little has been known about how global warming may affect mercury bioaccumulation in marine life, and no previous study has demonstrated the effects using fish in both laboratory and field experiments. Mercury released into the air through industrial pollution can accumulate in streams and oceans and is turned into methylmercury in the water...
'Pigging out' - some people could be genetically programmed to eat more food than others
Date: Oct-07-2013Researchers from University of Copenhagen have discovered big differences in the variability of eating habits among pigs. The newly published study - led by professor Haja Kadarmideen - is the first in the world looking at pig to human comparative genetic mapping to reveal key genes on the human genome that are known to be involved in obesity. With 30 million pigs produced in Denmark each year genomics scientist at University of Copenhagen Haja Kadarmideen decided to turn this to his advantage with his latest research on people's eating habits surrounding obesity and diabetes...
Active ingredient of ipecac syrup inhibits growth of bladder cancer cells
Date: Oct-07-2013An old home remedy called ipecac syrup, once stocked in medicine cabinets in case of accidental poisoning, is showing promise as a new chemotherapy drug for bladder cancer. Years ago ipecac syrup was used to induce vomiting in poisoning cases. Now a Loyola University Medical Center study has found that the active ingredient of ipecac syrup effectively inhibits the growth of bladder cancer cells, especially when combined with a standard chemotherapy drug...
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