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Electronic tool helps reduce deaths from pneumonia in emergency departments
Date: Sep-10-2013An electronic decision support tool helped to reduce deaths from pneumonia in four hospital emergency departments in a new study. The findings, which will be presented at the European Respiratory Society (ERS) Annual Congress in Barcelona on 11 September 2013, could lead to improvements in pneumonia care and outcomes for patients. Although guidelines for treating pneumonia exist, it is often difficult for these to be fully implemented in an emergency setting. The researchers therefore developed an electronic tool, linked to a patient's medical record...
Futile treatment in critical care common, costs can be substantial
Date: Sep-10-2013Critical care treatment for patients that was perceived to be futile was common and cost an estimated at $2.6 million at one academic medical center during a three-month period, according to a report published by JAMA Internal Medicine, a JAMA Network publication. Physicians often perceive as futile those intensive care interventions that prolong life without achieving an effect for the patient that would be viewed as a benefit. Thanh N. Huynh, M.D., M.S.H.S...
Drug patch treatment sees new breakthrough
Date: Sep-10-2013An assistant professor with the Virginia Tech - Wake Forest School of Biomedical Engineering has developed a flexible microneedle patch that allows drugs to be delivered directly and fully through the skin. The new patch can quicken drug delivery time while cutting waste, and can likely minimize side-effects in some cases, notable in vaccinations and cancer therapy. News of the delivery technology was published in a recent issue of the scientific journal, Advanced Materials...
Basic fibroblast growth factor protects injured spinal cord motor endplates
Date: Sep-10-2013In current studies, the degeneration and protection measures in the distal end of the injured spinal cord and target organ muscle effector have scarcely been investigated. The distal end of the spinal cord and neuromuscular junction may develop secondary degenera-tion and damage following spinal cord injury because of the loss of neural connections. The effect of basic fibroblast growth factor on motor neurons in the anterior horn of the injured spinal cord, and on the number of neuromuscular junctions in target organs, remains elusive...
'Y' stents effective for difficult-to-treat brain aneurysms
Date: Sep-10-2013A stent-assisted approach for difficult-to-treat brain aneurysms is reported in the September issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. Dr. Kyle M. Fargen of University of Florida and colleagues evaluated the use of "Y-stent coiling" to block off (occlude) aneurysms in 45 patients at seven U.S. hospitals. The stent-assisted technique was used for difficult-to-treat aneurysms located at the bifurcation (branching) of two blood vessels...
Bone growth factor may increase benign tumors but not malignant cancer
Date: Sep-10-2013Patients undergoing spinal fusion surgery with bone morphogenetic protein (BMP) appear to be at increased risk of benign tumors - but not cancers, reports a study in the September issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. BMP Linked to Increased Risk of Benign Tumors Dr. Nandan Lad of Duke University Medical Center and colleagues analyzed the risk of cancers and benign tumors in nearly 4,700 patients receiving BMP as part of spinal fusion surgery...
Hydrolyzed or non-hydrolyzed collagen: which one is suitable for nerve cell culture?
Date: Sep-10-2013In the central nervous system, nerve cells adhere to the extracellular matrix. Type I collagen is the major class of insoluble fibrous proteins in the extracellular matrix. A previous study has shown that neural stem and progenitor cells, cultured on collagen matrices, are able to expand actively and generate neurons. Collagens can be classified into hydrolyzed and non-hydrolyzed collagens, or two-dimensional and three-dimensional collagens. Which form of collagen is suitable for nerve cell culture? Dr...
Shuyusan appears to protect SH-SY5Y cells against corticosterone-induced impairment
Date: Sep-10-2013Synthetic antidepressants present a narrow spectrum and side effects following long-term application. Recently, medical practitioners have shown interest in the use of Chinese medicines for the treatment of diseases and in the adjustment of the human response to stress. Liping Chen and colleagues from Hainan Branch of Chinese PLA General Hospital have found in their preliminary studies that the Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage...
Salk scientists and colleagues discover important mechanism underlying Alzheimer's disease
Date: Sep-10-2013Alzheimer's disease affects more than 26 million people worldwide. It is predicted to skyrocket as boomers age - nearly 106 million people are projected to have the disease by 2050. Fortunately, scientists are making progress towards therapies. A collaboration among several research entities, including the Salk Institute and the Sanford-Burnham Medical Research Institute, has defined a key mechanism behind the disease's progress, giving hope that a newly modified Alzheimer's drug will be effective. In a previous study in 2009, Stephen F...
Fruit flies demonstrate that diet experience can alter taste preferences, USCB study shows
Date: Sep-10-2013If you've ever wondered how you learn to like a food you dislike, a new study conducted by UC Santa Barbara's Craig Montell, Duggan Professor of Neuroscience in the Department of Molecular, Cellular, and Developmental Biology, may offer an answer. The work addresses a central question in neurobiology - how experience can alter animal behavior. The research, just published in Nature Neuroscience, was conducted by Montell's team, which includes lead author Yali Zhang, Rakesh Raghuwanshi, and Wei Shen...
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