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Diabetes hospitalization: some antibiotics 'raise risk'
Date: Aug-15-2013Researchers have found that, compared with other antibiotics, people with diabetes taking a class known as fluoroquinolones may be at higher risk of blood sugar-related complications. Researchers from National Taiwan University in Taipei, carried out a population-based cohort study of around 78,000 people with diabetes...
Digital visualization in 3-D of cervical nerves in a healthy person
Date: Aug-15-2013High-resolution multilayer X-ray computer tomography and 3.0T superconducting magnetic resonance myelography are known to obtain a more complete and continuous two-dimensional original data. Three-dimensional reconstruction nerve models are classically obtained from two-dimensional images of "visible human" frozen sections. However, because of the flexibility of nerve tissues and small color differences compared with surrounding tissues, the integrity and validity of nerve tissues can be impaired during milling...
Mice experience therapeutic changes in glioma after transplantation of neural stem cells
Date: Aug-15-2013Neural stem cells transplanted into tumor-bearing rats can hinder tumor cell growth and proliferation; however, the mechanism remains unclear. Abnormal activation of the Ras/Raf/Mek/Erk signaling cascade plays an important role in glioma. Inhibition of this aberrant activity could effectively hinder glioma cell proliferation and promote cell apoptosis...
Possible new avenues for gene therapy via enhancer RNAs
Date: Aug-15-2013A study investigating the function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy. According to the study researchers, altering the production and function of these molecules could affect the expression of genes and, in consequence, possibly also the progression of various diseases. Published in the prestigious Molecular Cell, the study was carried out in collaboration between the University of California, San Diego and the University of Eastern Finland...
Researchers have developed an experimental therapy that can kill human blood cancer cells in the laboratory and eradicate the disease in mice
Date: Aug-15-2013Ottawa researchers have developed unique virus-derived particles that can kill human blood cancer cells in the laboratory and eradicate the disease in mice with few side effects. The study is published in Blood Cancer Journal by co-senior authors Drs. David Conrad and John Bell of the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa (uOttawa). While Dr...
Those who often recall their dreams respond more strongly to their name
Date: Aug-15-2013Dreaming remains one of the great mysteries of human cognition. It is still not fully known when dreams occur, and which mechanisms in the brain produce them. A major difficulty for studying dreams is that they leave only a fleeting memory upon awakening. Perrine Ruby and colleagues from the Lyon Neuroscience Research Center chose a new approach to investigate dreaming. They recorded brain activity of two groups of participants: high dream recallers who recall dreams nearly every day and low dream recallers who recall a dream once or twice a month...
New culprit identified that may make aging brains susceptible to neurodegenerative diseases
Date: Aug-15-2013The steady accumulation of a protein in healthy, aging brains may explain seniors' vulnerability to neurodegenerative disorders, a new study by researchers at the Stanford University School of Medicine reports. The study's unexpected findings could fundamentally change the way scientists think about neurodegenerative disease. The pharmaceutical industry has spent billions of dollars on futile clinical trials directed at treating Alzheimer's disease by ridding brains of a substance called amyloid plaque...
CDK6 represents a promising target for anti-cancer therapy
Date: Aug-15-2013Cell division is tightly controlled by a number of genes and because of the importance of ensuring that the process stays in check - mistakes frequently lead to cancer - mammalian cells often have several inbuilt layers of security. The two cyclin-dependent kinases CDK4 and CDK6 are widely believed to have almost identical functions, so either one of them can compensate for problems with the other. New work at the University of Veterinary Medicine, Vienna challenges this view and shows that, unlike CDK4, CDK6 also promotes the growth of blood vessels...
Gene expression may reveal who will benefit from vitamin D
Date: Aug-15-2013Studying the expression of genes that are dependent on vitamin D makes it possible to identify individuals who will benefit from vitamin D supplementation, shows a University of Eastern Finland study published recently in PLoS One. Population-based studies have shown that vitamin D deficiency may increase the risk for chronic diseases and weaken the body's immune system...
Repairing injured sciatic nerves
Date: Aug-15-2013The conventional method for repair of peripheral nerve injury is autogenous nerve grafting, but sources of autogenous nerve are limited. Furthermore, neurological deficits in the donor site and painful neuroma can occur following surgery. The use of allogeneic nerve grafts is limited because of host immune rejection. As reported, tensile stress and tensile strain directly affect the quality of nerve regeneration after bridging nerve defects by poly(lactic-co-glycolic acid) conduit transplantation and autogenous nerve grafting for sciatic nerve injury...
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