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Aggressive "triple-negative" breast cancers may be sensitive to drugs that clog their waste disposal
Date: Aug-14-2013In a new paper in Cancer Cell, a team led by Judy Lieberman, PhD, of Boston Children's Hospital's Program in Cellular and Molecular Medicine reports "triple-negative" breast cancers may be vulnerable to drugs that attack the proteasome. This cellular structure acts as the cell's waste disposal, breaking down damaged or unneeded proteins. These cancers, which lack the three major therapeutic markers for breast cancer - the estrogen, progesterone and HER2 receptors - are very aggressive and difficult to treat...
Personal website chronicling improves depressive symptoms in women with breast cancer
Date: Aug-14-2013Adults increasingly are conveying their personal experience with serious disease online, but do such chronicles help the authors or their audience? In the first known study of its kind, UCLA researchers have discovered that creating a personal website to chronicle the cancer experience and communicate with the author's interpersonal circle can reduce depressive symptoms, increase positive mood, and enhance appreciation for life in women diagnosed with breast cancer...
U.S. approval of Tivicay® (dolutegravir) for the treatment of HIV-1 announced
Date: Aug-14-2013ViiV Healthcare is pleased to announce that the U.S. Food and Drug Administration (FDA) has approved Tivicay(®) (dolutegravir) 50-mg tablets. Tivicay is an integrase inhibitor indicated for use in combination with other antiretroviral agents for the treatment of HIV-1 in adults and children aged 12 years and older weighing at least 40 kg (approx. 88 lbs). "Today is a very important milestone for patients and the scientists and teams who developed Tivicay and brought it to this point of FDA approval...
New strategy to disarm the dengue virus brings new hope for a universal dengue vaccine
Date: Aug-14-2013A new strategy that cripples the ability of the dengue virus to escape the host immune system has been discovered by A*STAR's Singapore Immunology Network (SIgN). This breakthrough strategy opens a door of hope to what may become the world's first universal dengue vaccine candidate that can give full protection from all four serotypes of the dreadful virus...
New Mums with Polycystic Ovary Syndrome - substantial link between high BMI's and low breastfeeding rates
Date: Aug-14-2013New Mums with Polycystic Ovary Syndrome (PCOS) are more likely to be overweight and less likely to breastfeed than their counterparts in the healthy weight range, say scientists. Already known to affect 1 in 5 Australian women, approximately one million women of childbearing age, PCOS is a growing concern and scientists are calling for further research into the clinical features including fertility issues associated with the condition...
Data from 2nd and 3rd cohorts of patients in multiple myeloma clinical trial
Date: Aug-14-2013Patrys Limited (ASX: PAB; "the Company"), a clinical stage biotechnology company, is pleased to release additional clinical data for six multiple myeloma patients treated with PAT-SM6 in the Phase I/IIa clinical trial. The six patients were involved in the 2nd and 3rd cohorts of the ongoing trial (three in each cohort), and their positive clinical outcomes supported the trial progressing to its 4th and final patient cohort. Recruitment of these patients is currently underway. The six patients (5 male and 1 female aged 65-75 years) had end-stage, multi-resistant multiple myeloma...
Irrigation in arid regions can increase malaria risk for a decade
Date: Aug-14-2013New irrigation systems in arid regions benefit farmers but can increase the local malaria risk for more than a decade - which is longer than previously believed - despite intensive and costly use of insecticides, new University of Michigan-led study in northwest India concludes. The study's findings demonstrate the need to include a strong, binding commitment to finance and implement long-term public health and safety programs when building large-scale irrigation projects, according to the researchers...
Research suggests neural stem cells may regenerate after anti-cancer treatment
Date: Aug-14-2013Scientists have long believed that healthy brain cells, once damaged by radiation designed to kill brain tumors, cannot regenerate. But new Johns Hopkins research in mice suggests that neural stem cells, the body's source of new brain cells, are resistant to radiation, and can be roused from a hibernation-like state to reproduce and generate new cells able to migrate, replace injured cells and potentially restore lost function...
Predicting which viral species are most likely to jump from animals to humans
Date: Aug-14-2013Outbreaks such as the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS) have afflicted people around the world, yet many people think these trends are on the decline. Quite the opposite is true. The efforts to combat this epidemic are being spearheaded by a team of Lawrence Livermore National Laboratory (LLNL) scientists. Led by Monica Borucki of LLNL's Biosciences and Biotechnology Division, the Lab researchers have made promising new discoveries that provide insight into the emergence of inter-species transmittable viruses...
Male youths who are beer-drinkers binge-drink more frequently
Date: Aug-14-2013Just under a third of young Swiss men prefer beer when they drink alcohol, taking in at least two thirds of their alcohol consumption in the form of the beverage. Far fewer (around five percent) prefer wine...
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