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Essential gene regulator for healthy retinal development and good vision in adulthood

Date: Aug-12-2013
Scientists are developing a clearer picture of how visual systems develop in mammals. The findings offer important clues to the origin of retinal disorders later in life. In research published in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cells...

Pediatric care in rural emergency rooms significantly improved by telemedicine consultations

Date: Aug-12-2013
Telemedicine consultations with pediatric critical-care medicine physicians significantly improve the quality of care for seriously ill and injured children treated in remote rural emergency rooms, where pediatricians and pediatric specialists are scarce, a study by researchers at UC Davis Children's Hospital has found. The study also found that rural emergency room physicians are more likely to adjust their pediatric patients' diagnoses and course of treatment after a live, interactive videoconference with a specialist...

New approach to profiling and predicting the behavior of proteins

Date: Aug-12-2013
An enzyme is a tiny, well-oiled machine. A class of proteins that are made up of multiple, interlocking molecular components, enzymes perform a variety of tasks inside each cell. However, precisely how these components work together to complete these tasks has long eluded scientists. But now, a team of researchers has found a way to map an enzyme's underlying molecular machinery, revealing patterns that could allow them to predict how an enzyme behaves - and what happens when this process disrupted...

Lymphoma 'triggered by immune-regulating molecules'

Date: Aug-12-2013
Scientists have discovered that a small group of immune-regulating molecules could trigger lymphoma, according to a study published in the The Embo Journal. Researchers from The Scripps Research Institute (TSRI) in California have found that six microRNA molecules - short molecules found in nearly all animal and plant cells, may be responsible for lymphoma when overproduced. Each microRNA acts as a "dimmer switch" for one or more genes, according to the researchers. They work by binding to the genes and preventing them from being changed into proteins...

Genetically engineered proteins enable scientists to watch live brain cell circuits spark and fire

Date: Aug-12-2013
Scientists used fruit flies to show for the first time that a new class of genetically engineered proteins can be used to watch nerve cell electrical activity in live brains. The results, published in Cell, suggest these proteins may be a promising new tool for mapping brain cell activity in multiple animals and for studying how neurological disorders disrupt normal nerve cell signaling. Understanding brain cell activity is a high priority of the President's Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative...

Drug design to target cancer and inflammatory disease aided by chemists

Date: Aug-12-2013
Chemists at Indiana University Bloomington have produced detailed descriptions of the structure and molecular properties of human folate receptor proteins, a key development for designing new drugs that can target cancer and inflammatory diseases without serious side effects. The researchers, from the lab of Charles Dann III, assistant professor of chemistry in the College of Arts and Sciences, published their findings in the Proceedings of the National Academy of Sciences...

Improving student health at elementary and middle schools

Date: Aug-12-2013
Despite widespread cuts to physical education classes and recess, an Indiana University study has shown that schools can play an important role in helping their students live healthier lives. Schools that implemented coordinated school health programs saw increases in students' physical activity. "With support from teachers, administrators and parents, our schools can become healthier places," said Mindy Hightower King, evaluation manager at the Indiana Institute on Disability and Community at IU Bloomington...

New research sheds light on previously under-researched area of study - females with autism

Date: Aug-12-2013
Autism affects different parts of the brain in females with autism than males with autism, a new study reveals. The research is published in the journal Brain as an open-access article. Scientists at the Autism Research Centre at the University of Cambridge used magnetic resonance imaging to examine whether autism affects the brain of males and females in a similar or different way...

New microfluidic chip can capture live tumor cells in the blood

Date: Aug-12-2013
Tumor cells circulating within a patient's bloodstream can carry cancer from a primary tumor site to distant sites of the body, spreading the disease. Now a team of researchers in China has developed a new microfluidic chip that can quickly and efficiently segregate and capture live circulating tumor cells (CTCs) from a patient's blood, with potential applications for cancer screenings and treatment assessments. The researchers describe their technique in the journal Biomicrofluidics, which is produced by AIP Publishing...

Study identifies 3 enzymes required for building sugar superstructure involved in muscular dystrophies

Date: Aug-12-2013
For many inherited diseases, such as cystic fibrosis or Huntington disease, the disease-causing genetic mutation damages or removes a protein that has an essential role in the body. This protein defect is the root cause of the disease symptoms. However, for a group of muscular dystrophies known collectively as congenital muscular dystrophies (CMDs), the sequence of the protein that is central to normal function is typically unaffected. Instead, the defects lie in processing proteins - ones that are responsible for modifying the central protein by adding sugar chains (glycans)...