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Researchers develop efficient model for generating human iPSCs
Date: Aug-06-2013Researchers at the University of California, San Diego School of Medicine report a simple, easily reproducible RNA-based method of generating human induced pluripotent stem cells (iPSCs) in the August 1 edition of Cell Stem Cell. Their approach has broad applicability for the successful production of iPSCs for use in human stem cell studies and eventual cell therapies...
Scientists discover a molecular 'switch' in cancers of the testis and ovary - LIN28
Date: Aug-06-2013Cambridge scientists have identified an 'on/off' switch in a type of cancer which typically occurs in the testes and ovaries called 'malignant germ cell tumours'. The research was published on 1st August, in the journal Cancer Research. Malignant germ cell tumours arise in sperm- or egg-forming cells and usually occur in the reproductive organs, the testes or ovaries. The cancerous tumours are seen in patients of all ages, both in childhood and adulthood...
Stray prenatal gene network suspected in schizophrenia
Date: Aug-06-2013Researchers have reverse-engineered the outlines of a disrupted prenatal gene network in schizophrenia, by tracing spontaneous mutations to where and when they likely cause damage in the brain. Some people with the brain disorder may suffer from impaired birth of new neurons, or neurogenesis, in the front of their brain during prenatal development, suggests the study, which was funded by the National Institutes of Health. "Processes critical for the brain's development can be revealed by the mutations that disrupt them," explained Mary-Claire King, Ph.D...
Scientists find long-sought method to efficiently make ingenol a complex anticancer compound
Date: Aug-06-2013Scientists at The Scripps Research Institute (TSRI) have achieved the first efficient chemical synthesis of ingenol, a highly complex, plant-derived compound that has long been of interest to drug developers for its anticancer potential. The achievement will enable scientists to synthesize a wide variety of ingenol derivatives and investigate their therapeutic properties...
Potential nutritional therapy for childhood neurodegenerative disease
Date: Aug-06-2013Researchers at the University of California, San Diego School of Medicine have identified the gene mutation responsible for a particularly severe form of pontocerebellar hypoplasia, a currently incurable neurodegenerative disease affecting children. Based on results in cultured cells, they are hopeful that a nutritional supplement may one day be able to prevent or reverse the condition. The study, from a team of international collaborators led by Joseph G...
New designer compound treats heart failure by targeting cell nucleus
Date: Aug-06-2013Researchers from Case Western Reserve University School of Medicine and the Dana-Farber Cancer Institute have made a fundamental discovery relevant to the understanding and treatment of heart failure - a leading cause of death worldwide. The team discovered a new molecular pathway responsible for causing heart failure and showed that a first-in-class prototype drug, JQ1, blocks this pathway to protect the heart from damage. In contrast to standard therapies for heart failure, JQ1 works directly within the cell's command center, or nucleus, to prevent damaging stress responses...
Ultrasound patch heals venous ulcers in human trial
Date: Aug-06-2013In a small clinical study, researchers administered a new method for treating chronic wounds using a novel ultrasound applicator that can be worn like a band-aid. The applicator delivers low-frequency, low-intensity ultrasound directly to wounds, and was found to significantly accelerate healing in five patients with venous ulcers. Venous ulcers are caused when valves in the veins malfunction, causing blood to pool in the leg instead of returning to the heart...
Celiacs may be at higher lymphoma risk
Date: Aug-06-2013People who have poorly controlled celiac disease may have a higher risk of developing lymphoma, according to a study published in the journal Annals of Internal Medicine. Researchers from Sweden carried out a population-based cohort study of 7,625 patients with celiac disease (CD) between 2006 and 2008. The study looked at patients who had a follow-up biopsy of the gut after their initial diagnosis. Data of patient's biopsies was collected from 28 of Sweden's pathology departments, conducted between 1969 to 2008...
Outgoing mothers more likely to breastfeed
Date: Aug-06-2013Mothers who are more outgoing and less anxious are more likely to breastfeed compared with introvert or anxious mothers, according to a study published in the Journal of Advanced Nursing. Dr. Amy Brown, of Swansea University in the UK, says the research revealed that new mothers with particular personalities may need additional support and knowledge before feeling confident about breastfeeding their babies. The study involved 602 mothers with infants aged between 6 and 12 months...
Clues to how brains focus on long-term goals
Date: Aug-06-2013Those of you who have ever taken a long road trip know how satisfying it is to finally reach your destination. There is always that long-term goal spurring you on to complete your journey. But what exactly is it that keeps us focused? Researchers from the Massachusetts Institute of Technology (MIT) believe their new study may reveal the answer. The study, published in the journal Nature, suggests that the neurotransmitter, dopamine, plays a part in how the brain signals the value of long-term rewards...
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