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Targeted therapy identified for protein that protects and nourishes cancer - inhibitor found that blocks Skp2
Date: Aug-05-2013Scientists at The University of Texas MD Anderson who identified a protein's dual role in cancer promotion have discovered a way to shut it down, opening a potential new avenue for cancer treatment. Reporting this week in the journal Cell, the researchers describe the first compound that directly binds to and blocks Skp2, a protein they previously showed both turns off a cellular defense against cancer and switches on a cancer-feeding metabolic pathway. "The beauty of this study is we identified an inhibitor and showed how it functions to block Skp2...
Blocking sugar intake may reduce cancer risk or progression in obese and diabetic people
Date: Aug-05-2013Blocking dietary sugar and its activity in tumor cells may reduce cancer risk and progression, according to researchers from the Icahn School of Medicine. The study, conducted in fruit flies and published in the journal Cell, provides insight as to why metabolism-related diseases such as diabetes or obesity are associated with certain types of cancer, including pancreatic, breast, liver, and colon cancers...
Researchers map a new metabolic pathway that controls mTORC1 activation which is involved in cell growth
Date: Aug-05-2013Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular pathway that can lead to cancer and diabetes. In the study published by Molecular Cell, the scientists uncovered how a protein called p62 has a cascade affect in regulating cell growth in response to the presence of nutrients such as amino acids and glucose. Disrupting this chain may offer a new approach to treating disease...
New insight into how brain 'learns' cocaine addiction
Date: Aug-05-2013A team of researchers says it has solved the longstanding puzzle of why a key protein linked to learning is also needed to become addicted to cocaine. Results of the study, published in the Aug. 1 issue of the journal Cell, describe how the learning-related protein works with other proteins to forge new pathways in the brain in response to a drug-induced rush of the "pleasure" molecule dopamine. By adding important detail to the process of addiction, the researchers, led by a group at Johns Hopkins, say the work may point the way to new treatments...
The when and where of the Y: Research on Y chromosomes finds new clues about human ancestry
Date: Aug-05-2013More than 7 billion people live on this planet - members of a single species that originated in one place and migrated all over the Earth over tens of thousands of years. But even though we all trace our family lineage to a few common ancestors, scientists still don't know exactly when and how those few ancestors started to give rise to the incredible diversity of today's population. A brand-new finding, made using advanced analysis of DNA from all over the world, sheds new light on this mystery...
The 4-point test to predict death risk from C. difficile
Date: Aug-05-2013A Clostridium difficile (C. diff) infection is one that can affect the digestive system and most commonly affects people staying in hospital. It is not generally a problem for healthy people but may infect those on antibiotics with an imbalance of 'good bacteria' in the gut. A research paper published on the 2nd August 2013, in BMC Infectious Diseases has for the first time identified a unique four-point test using easily measurable clinical variables which can be used to accurately predict the death risk to patients from C. diff...
Children with elevated blood pressure don't get recommended follow-up, few at risk for hypertension - recheck during initial visit
Date: Aug-05-2013Children who have a first elevated blood pressure at the doctor's office are not likely to receive the recommended follow-up blood pressure readings within a month, according to a study published in Pediatrics. However, when the blood pressure was later repeated, most children's blood pressure returned to normal for their age, sex and height...
Fetal stress disrupts the way genes are transmitted
Date: Aug-05-2013If you think stress is killing you, you may be right, but what you don't know is that stress might have harmed your health even before you were born. In a new report appearing in the August 2013 issue of The FASEB Journal, Harvard researchers find that epigenetic disruptions, which are associated with chronic disease later in life, are already common at birth. Possibly, these aberrations result from stressors in the intrauterine environment (e.g. maternal smoking, maternal diet, or high levels of endocrine-disrupting chemicals)...
Study reveals target for drug development for temporomandibular joint disorder (TMJD) - a chronic jaw pain disorder
Date: Aug-05-2013Temporomandibular joint disorder (TMJD) is the most common form of oral or facial pain, affecting over 10 million Americans. The chronic disorder can cause severe pain often associated with chewing or biting down, and lacks effective treatments. In a study in mice, researchers at Duke Medicine identified a protein that is critical to TMJD pain, and could be a promising target for developing treatments for the disorder. Their findings are published in the August issue of the journal PAIN. Aside from cases related to trauma, little is known about the root cause of TMJD...
Which? launches new hearing aid guide with UK hearing loss charity
Date: Aug-05-2013Action on Hearing Loss has joined forces with consumer champion Which? to launch a comprehensive guide to hearing aids. This will give people with hearing loss the help they need to ensure they get the hearing aid that is right for them. How to get the best hearing aid provides in-depth advice for anyone who is unsure about the steps they need to take in order to improve their hearing. The advice covers everything from getting a hearing assessment from an Audiologist, to choosing a hearing aid and what they should do if there are any problems once it has been fitted...
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