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Detrusor overactivity post-stroke responds to electroacupuncture
Date: Jul-24-2013Detrusor overactivity is common after stroke, and is characterized by frequent micturition and urinary incontinence. However, the optimal treatment for post-stroke detrusor overactivity remains unclear. According to a study reported in Neural Regeneration Research (Vol. 8, No...
In patients with kidney disease, calcium linked to increased risk of heart disease and death
Date: Jul-24-2013Kidney patients who take calcium supplements to lower their phosphorous levels may be at a 22 per cent higher risk of death than those who take other non-calcium based treatments, according to a new study by Women's College Hospital's Dr. Sophie Jamal. The study, published in the Lancet, calls into question the long-time practice of prescribing calcium to lower phosphate levels in patients with chronic kidney disease...
New functions identified for autoimmune disease 'risk' gene
Date: Jul-24-2013Researchers at the University of Minnesota have identified infection-fighting and inflammation-suppressing functions for a gene associated with human autoimmune disease. The discovery, centered on a gene known as PTPN22, could set into motion new treatment approaches for autoimmune diseases like lupus, rheumatoid arthritis and type 1 diabetes. The key to these advances may lie with a better understanding of how a variant of PTPN22, known as a "risk variant," impacts autoimmune disease development and the behavior of myeloid cells that act as the body's "first responders...
Two-drug combination, under certain circumstances, can theoretically eliminate cancer
Date: Jul-24-2013New research conducted by Harvard scientists is laying out a road map to one of the holy grails of modern medicine: a cure for cancer. As described in a paper recently published in eLife, Martin Nowak, a professor of mathematics and of biology and director of the Program for Evolutionary Dynamics, and co-author Ivana Bozic, a postdoctoral fellow in mathematics, show that, under certain conditions, using two drugs in a "targeted therapy" - a treatment approach designed to interrupt cancer's ability to grow and spread - could effectively cure nearly all cancers...
How interferon beta proteins bind to cells and activate an immune response
Date: Jul-24-2013Monash University researchers have gained new insight into the early stages of our immune response, providing novel pathways to develop treatments for diseases from multiple sclerosis to cancer. In a study published in Nature Immunology, a team of researchers led by Professor Paul Hertzog, of the Monash Institute of Medical Research (MIMR) and Professor Jamie Rossjohn, of the School of Biomedical Sciences, have characterised for the first time how interferon beta (IFNβ) proteins bind to cells and activate an immune response...
Should cancer screening be stopped as dementia progresses?
Date: Jul-24-2013Research from the Regenstrief Institute and the Indiana University Center for Aging Research has found that many family caregivers of older adults with dementia are willing to consider stopping cancer screening of the elderly individual; they are also relieved when the older adult's physician brings it up...
A unique pathway identified in the human brain allows us to learn new words
Date: Jul-24-2013The average adult's vocabulary consists of about 30,000 words. This ability seems unique to humans as even the species closest to us - chimps - manage to learn no more than 100. It has long been believed that language learning depends on the integration of hearing and repeating words but the neural mechanisms behind learning new words remained unclear. Previous studies have shown that this may be related to a pathway in the brain only found in humans and that humans can learn only words that they can articulate...
Genetics and live cell imaging illuminate molecular mechanisms that position the cell division machinery in growing tissues
Date: Jul-24-2013Constructing a body is like building a house - if you compromise structural integrity, the edifice can collapse. Nowhere is that clearer on a cellular level than in the case of epithelial sheets, single layers of cells that line every body cavity from the gut to mammary glands. As long as epithelial cells pack tightly and adhere to their neighbors, the cellular business of building tissue barriers and constructing ducts goes smoothly. But if epithelial cells fail to hold together, they die, or worse, produce jumbled masses resembling tumors known collectively as carcinomas...
Quickly clearing away damaged proteins may help prevent neurodegenerative disorders
Date: Jul-24-2013Recycling is not only good for the environment, it's good for the brain. A study using rat cells indicates that quickly clearing out defective proteins in the brain may prevent loss of brain cells. Results of a study in Nature Chemical Biology suggest that the speed at which damaged proteins are cleared from neurons may affect cell survival and may explain why some cells are targeted for death in neurodegenerative disorders. The research was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health...
Vascular dementia safely and effectively treated by Chinese herbal medicines
Date: Jul-24-2013Chinese herbal medicine, which has been used for thousands of years in China, has long been considered an effective treatment for vascular dementia. There are already meta-analyses of the effects of herbal extracts (ginkgo biloba and huperzine A) on vascular dementia. However, there has been no systematic review of the efficacy and safety of Chinese herbal medicines for vascular dementia, despite its wide use in clinical practice. A recent study published in the Neural Regeneration Research (Vol. 8, No...
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