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What Is Gaucher's Disease? What Causes Gaucher's Disease?
Date: Jul-15-2013Gaucher's (Gaucher) disease, also known as glucocerebrosidase deficiency, occurs when a certain lipid, glucosylceramide, accumulates in the bone marrow, lungs, spleen, liver and sometimes the brain. Patients with Gaucher's disease have a hereditary deficiency of glucocerebrosidase, an enzyme that helps the body process glucosylceramide. Glucosylceramide is also known as glucocerebroside. When glucocerebrosidase is faulty, the lipid (fat) glucosylceramide builds up, especially in the macrophages. Macrophage is a type of white blood cell...
One-Year Mortality Remains High In Patients With Prosthetic Valve Endocarditis, No Significant Difference With Early Valve Surgery Vs. Medical Therapy
Date: Jul-15-2013Prosthetic valve endocarditis (inflammation and infection involving the heart valves and lining of the heart chambers) remains associated with a high one-year mortality rate and early valve replacement does not appear to be associated with lower mortality compared with medical therapy according to a study by Tahaniyat Lalani, M.D., M.H.S., of the Naval Medical Center, Portsmouth, Virginia, and colleagues...
An End-Of-Life "Conversation Guide" For Physicians To Speak With Patients
Date: Jul-15-2013How does a doctor tackle the delicate issue of end-of-life care planning with a patient? With an aging population and people living longer with chronic illness, it is increasingly important for patients and family members to decide how they and their loved ones would like to spend their final days. And for physicians in both hospital and primary care settings, it is crucial that they know how to address this issue with sensitivity...
Current Blood Transfusion Practice In Trauma Centres Feasible But Wastes Scarce Plasma
Date: Jul-15-2013The use of a 1:1:1 blood transfusion protocol in patients with severe trauma is feasible in hospitals, although it is associated with higher waste of plasma, according to a randomized trial published in CMAJ (Canadian Medical Association Journal). Previous retrospective studies suggested that a 1:1:1 transfusion strategy or fixed-ratio transfusion could reduce the number of deaths from hemorrhage; therefore, the strategy has been widely adopted in trauma centres around the world and for nontrauma patients...
2nd International Conference On Medicinal Chemistry & Computer Aided Drug Designing, October 15-17, 2013, Las Vegas
Date: Jul-15-2013MedChem & CADD-2013 is a remarkable event which brings together pharmaceutical companies, leading universities, small biotechnology enterprises, government agencies and research institutions to share ideas, experiences, make connections and evaluate emerging opportunities to create an environment that will foster pharmaceutical innovations. The scientific program will focus on the current advances in the research field as well as serve as a catalyst for the advancement of Medicinal Chemistry and Drug Designing...
Eating Fish While Pregnant May Lower Anxiety Levels
Date: Jul-15-2013Pregnant women have many choices to make when eating for two. What supplements to take, which cheeses to avoid, how much (if any) alcohol is safe to consume, and which fish to avoid - with so many decisions to make just over their food, it's no wonder pregnant women can experience anxiety. But a new study - from researchers at the UK's Bristol University and Brazil's Federal University of Rio de Janeiro - reveals that pregnant women who eat seafood frequently will likely have lower levels of overall anxiety than those who do not...
Mouse Cloned From Drop Of Tail Blood
Date: Jun-28-2013For the first time, scientists in Japan have cloned a mouse using just a drop of blood taken from its tail. The result is important because it gives scientists a new way to preserve strains of lab mice for the study of human diseases. The female clone proved to be fertile by natural mating and lived for 23 months, which is about normal for a lab mouse, researchers from RIKEN BioResource Center in Tsukuba, Japan, report in a paper published online in the journal Biology of Reproduction on 26 June...
Think Uncertainty Is A Bad Thing? It's Actually A Mark Of Sound Science
Date: Jun-28-2013Scientists and research institutes are challenging the idea that uncertainty in research is a reason for people to worry about the reliability of findings. Researchers in climate science, disease modelling, epidemiology, weather forecasting and natural hazard prediction say that we should be relieved when scientists describe the uncertainties in their work. It doesn't necessarily mean that we cannot make decisions - we might well have 'operational knowledge' - but it does mean that there is greater confidence about what is known and unknown...
New Fycompa® (Perampanel) Data Presented At International Epilepsy Congress (IEC)
Date: Jun-28-2013New data provides additional evidence for use of Fycompa in partial-onset epilepsy New data from 11 abstracts, including two oral presentations, presented at the 30th International Epilepsy Congress (IEC) in Montreal, Canada provide additional data on the safety, efficacy and impact on quality of life (QOL) of once daily Fycompa(R) (perampanel) as adjunct treatment in partial-onset epilepsy, the most common form of seizures...
University Of East Anglia Scientists Make Major Advances Important For Cancer Research
Date: Jun-28-2013Scientists at the University of East Anglia have made a major advancement in understanding tissue development that has important implications for cancer. Findings published today in the journal Cell Science show how the protein EB2 is a key regulator of tube-like structures inside cells and critical for normal tissue development and function. The findings are an important step in the race to find cures for cancers including gut, breast and pancreatic cancer. Microtubules are tubular structures that make up the internal 'skeleton' of cells and perform many essential functions...
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