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Whole Genome Or Exome Sequencing: An Individual Insight

Date: Jun-27-2013
Focusing on parts rather than the whole, when it comes to genome sequencing, might be extremely useful, finds research in BioMed Central's open access journal Genome Medicine. The research compares several sequencing technologies in the same individual with Charcot-Marie-Tooth disease (CMT), and shows that sequencing the coding regions alone at high depth of coverage can identify the genetic variation behind this disease, and was also able to resolve previous ambiguities...

From Tiny To Huge - Mammal Size Evolution Explained

Date: Jun-27-2013
Scientists have added another piece to the evolutionary puzzle to explain why certain mammal families evolved to be very large, while others remained tiny. In research published in Proceedings of the Royal Society B, an international group of scientists including Monash University's Dr Alistair Evans proposed a new theory explaining the diversity of mammal sizes - from the Etruscan shrew which weighs around two grams, to the blue whale which clocks in at almost 200 tonnes. Surprisingly, baby weight relative to adult body mass is key...

First ESC Cardiac Pacing And Resynchronization Guidelines Ever To Incorporate A New Section Called 'Clinical Perspectives'

Date: Jun-27-2013
The 2013 ESC Guidelines on Cardiac Pacing and Cardiac Resynchronization Therapy developed in collaboration with the European Heart Rhythm Association (EHRA), have created a new classification system for bradyarrhythmias according to mechanisms rather than aetiology. The guidelines, presented at the EHRA EUROPACE meeting in Athens, Greece, and published simultaneously in the European Heart Journal and Europace, have been redesigned to offer a more accessible format for users...

Exploring Food Riddles In Rhythm Disturbances

Date: Jun-27-2013
Drinking excessive amounts of cola and eating honey made from the pollen of Rhododendrons can cause unusual syncope (fainting) and symptoms of arrhythmia, report two case studies presented as abstracts at the EHRA EUROPACE 2013 meeting, in Athens. "Both these studies underline the importance of clinicians taking detailed medical histories for patients with unexplained arrhythmias and including questions about their dietary intakes," says Professor Andreas Goette, the EHRA Scientific Programme Committee chairperson. In the first abstract Dr. Naima Zarqane and Prof...

Study Points To Potential Strategy For Erasing Memory Of Addiction

Date: Jun-27-2013
A new study by researchers at the Ernest Gallo Clinic and Research Center at UC San Francisco offers encouraging findings that researchers hope may one day lead to a treatment option for people who suffer from alcohol abuse disorders and other addictions. In the study, conducted in rats, the UCSF researchers were able to identify and deactivate a brain pathway linked to the memories that cause cravings for alcohol, thus preventing the animals from seeking alcohol and drinking it, the equivalent of relapse...

The Benefits Of Exercise For Patients With Type 2 Diabetes

Date: Jun-27-2013
Moderate-intensity exercise reduces fat stored around the heart, in the liver and in the abdomen of people with type 2 diabetes mellitus, even in the absence of any changes in diet, according to a new study published online in the journal Radiology. Type 2 diabetes occurs when the body does not produce enough insulin, a hormone that regulates the movement of sugar into the cells, or when the cells resist the effects of insulin. The disease can lead to a wide range of complications, including damage to the eyes and kidneys and hardening of the arteries...

In Emergency Department Imaging, Patient Factors Play Key Role

Date: Jun-27-2013
Despite concerns to the contrary, very little of the variation in Emergency Department (ED) imaging utilization is attributable to physician experience, training or gender, according to a new study published online in the journal Radiology. Imaging exams like X-rays and CT scans are common in the ED. In 2010, slightly more than 47 percent of all ED visits in the United States had an imaging exam associated with them. "Analyzing and understanding drivers of use of imaging in the ED is important for several reasons," said Christopher L. Sistrom, M.D., M.P.H., Ph.D...

How The Framing Of Portion Size Influences Food Choice

Date: Jun-27-2013
Just what size is a "small" drink - 8 ounces, 12 ounces, 16 ounces? The truth is, those are all "small" sizes depending on what restaurants and fast food joints you go to. As customers, we are used to ordering food based on relative size, but according to a new study from Cornell University, these seemingly standard labels impact our entire eating experience. Dr. David R. Just and Dr. Brian Wansink of the Cornell Food & Brand Lab designed a study to understand how portion labels impact what you're willing to pay for your food as well as how much you actually eat...

Gene Transfer May Play Role In Cancer, Other Diseases Linked With DNA Damage

Date: Jun-27-2013
Bacterial DNA may integrate into the human genome more readily in tumors than in normal human tissue, scientists have found. The researchers, affiliated with the University of Maryland School of Medicine's Institute for Genome Sciences, analyzed genomic sequencing data available from the Human Genome Project, the 1,000 Genomes Project and The Cancer Genome Atlas. They considered the phenomenon of lateral gene transfer (LGT), the transmission of genetic material between organisms in a manner other than than traditional reproduction...

After Lumpectomy For Breast Cancer, Rural Women Less Likely To Get Radiation Therapy

Date: Jun-27-2013
Rural women with breast cancer are less likely than their urban counterparts to receive recommended radiation therapy after having a lumpectomy, a breast-sparing surgery that removes only tumors and surrounding tissue, a study by Mayo Clinic and others found. The difference is one of several rural disparities in breast cancer diagnosis and treatment the researchers discovered. The findings are being presented at the AcademyHealth Annual Research Meeting in Baltimore. "These study results are concerning," says Elizabeth Habermann, Ph.D...