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Previously Unknown Surveillance Mechanism Used By Cells To Monitor Oxidatively Damaged DNA
Date: Jun-18-2013In current health lore, antioxidants are all the rage, as "everybody knows" that reducing the amount of "reactive oxygen species" -- cell-damaging molecules that are byproducts of cellular metabolism -- is critical to staying healthy. What everyone doesn't know is that our bodies already have a complex set of processes built into our cells that handle these harmful byproducts of living and repair the damage they cause...
Neurons Identified That Control Feeding Behavior In Drosophila
Date: Jun-18-2013Scientists at the University of Massachusetts Medical School have developed a novel transgenic system which allows them to remotely activate individual brain cells in the model organism Drosophila using ambient temperature. This powerful new tool for identifying and characterizing neural circuitry has lead to the identification of a pair of neurons - now called Fdg neurons - in the fruit fly that decide when to eat and initiate the subsequent feeding action...
Variant Of Main Painkiller Receptor Designed
Date: Jun-18-2013Opioids, such as morphine, are still the most effective class of painkillers, but they come with unwanted side effects and can also be addictive and deadly at high doses. Designing new pain-killing drugs of this type involves testing them on their corresponding receptors, but access to meaningful quantities of these receptors that can work in experimental conditions has always been a limiting factor...
The Genetics Of Dyslexia And Language Impairment
Date: Jun-18-2013A new study of the genetic origins of dyslexia and other learning disabilities could allow for earlier diagnoses and more successful interventions, according to researchers at Yale School of Medicine. Many students now are not diagnosed until high school, at which point treatments are less effective. The study is published online and in the July print issue of the American Journal of Human Genetics. Senior author Jeffrey R. Gruen, M.D...
New Software System Could Help With Social Interactions, Social Phobias
Date: Jun-18-2013Social phobias affect about 15 million adults in the United States, according to the National Institute of Mental Health, and surveys show that public speaking is high on the list of such phobias. For some people, these fears of social situations can be especially acute: For example, individuals with Asperger's syndrome often have difficulty making eye contact and reacting appropriately to social cues. But with appropriate training, such difficulties can often be overcome...
Vestibular Prosthesis To Help Restore Balance For Those With Meniere's Disease
Date: Jun-18-2013Many disorders of the inner hear which affect both hearing and balance can be hugely debilitating and are currently largely incurable. Cochlear implants have been used for many years to replace lost hearing resulting from inner ear damage. However, to date, there has not been an analogous treatment for balance disorders resulting from inner ear disease. One potential new treatment is an implantable vestibular prosthesis which would directly activate the vestibular nerve by electrical stimulation...
NSAID Prescription In At-Risk Patients Increases Likelihood Of Heart Attack/Death In Primary Care
Date: Jun-18-2013New study data presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, demonstrate a high prevalence of NSAID prescriptions in patients at risk of ischaemic heart disease (IHD). Published evidence suggest significant cardiovascular implications of NSAIDs for patients, with an immediate mortality risk demonstrated in patients who had suffered a myocardial infarction (MI, heart attack) even when prescribed treatment duration was less than one week.2 NSAIDs are used to relieve pain and signs of inflammation, such as fever, swelling and redness...
Growth Of Breast Cancer Cells Halted By Osteoporosis Drug, Even In Resistant Tumors
Date: Jun-18-2013A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute study. The findings, presented at the annual Endocrine Society meeting in San Francisco, indicate that the drug bazedoxifene packs a powerful one-two punch that not only prevents estrogen from fueling breast cancer cell growth, but also flags the estrogen receptor for destruction...
Landmark Clinical Guidelines For Hypertension Treatment Introduced At Europe's Biggest Blood Pressure Conference In Milan
Date: Jun-18-2013Lifestyle factors, lack of awareness by both patients and physicians, hesitancy in initiating and intensifying drug treatment, and healthcare structural deficiencies are amongst the reasons for the increasing problem of high blood pressure in Europe, according to new joint Guidelines issued by the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)...
New Fluorescent Protein From Eel Revolutionizes Key Clinical Assay
Date: Jun-18-2013Many scientists dream of making a single discovery that provides fundamental insight into nature, may be used to help save human lives, and can assist in the preservation of an endangered species. In new research reported in the journal Cell, a Japanese team is on the verge of accomplishing this nearly impossible feat...
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