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FDA-Approved Drugs May Reduce Devastating Symptoms Of Tay-Sachs Disease
Date: Jun-10-2013A team of researchers has made a significant discovery which may have a dramatic impact on children stricken with Tay-Sachs disease, a degenerative and fatal neurological condition that often strikes in the early months of life. Available drugs may dramatically ease a child's suffering, say scientists. "There is hope for this disease," says Suleiman Igdoura, lead researcher of the study and an associate professor of biology at McMaster University...
Tracking A Gene From Its Birth Through Its Pathway To Purpose And Evolutionary Importance
Date: Jun-10-2013Fred Hutchinson Cancer Research Center scientists have, for the first time, mapped a young gene's short, dramatic evolutionary journey to becoming essential, or indispensable. In a study published online in Science, the researchers detail one gene's rapid switch to a new and essential function in the fruit fly, challenging the long-held belief that only ancient genes are important. "We really haven't paid much attention to what is new, because there's so much emphasis on what is old," said Harmit Singh Malik, Ph.D...
Human Embryonic Stem Cells Can Be Differentiated Into Liver Progenitor Cells And Produce Mature Liver Cells
Date: Jun-10-2013Liver transplantation is the mainstay of treatment for patients with end-stage liver disease, the 12th leading cause of death in the United States, but new research from the Icahn School of Medicine at Mount Sinai, published in the online journal Cell Stem Cell, suggests that it may one day become possible to regenerate a liver using cell therapy in patients with liver disease. Investigators discovered that a human embryonic stem cell can be differentiated into a previously unknown liver progenitor cell, an early offspring of a stem cell, and produce mature and functional liver cells...
Stem Cell Research Advanced By Rewinding Development
Date: Jun-10-2013Scientists at the Danish Stem Cell Center, DanStem, at the University of Copenhagen have discovered that they can make embryonic stem cells regress to a stage of development where they are able to make placenta cells as well as the other fetal cells. This significant discovery, published in the journal Cell Reports, has the potential to shed new light on placenta related disorders that can lead to problematic pregnancies and miscarriages. Embryonic stem cells can make all kinds of adult cells in the human body such as muscle, blood or brain cells...
Risk Of Stroke Can Be Reduced By Minor Changes In Cardiovascular Health
Date: Jun-10-2013A report, published in Stroke, showed that small improvements in cardiovascular risk factors reduce the chances a person will suffer a stroke. The report is part of an ongoing national study called Reasons for Geographic and Racial Differences in Stroke (REGARDS) which is funded by NIH's National Institute of Neurological Disorders and Stroke. Stroke is a leading cause of death and disability in the United States. Strokes are caused by abnormal changes in blood flow in the brain or the bursting of brain blood vessels...
China's Rapid Change Has Led To Significant Improvements In Health
Date: Jun-10-2013China made substantial gains in health over the past two decades, including increases in life expectancy, reductions in child mortality, and declines in infectious diseases such as tuberculosis and lower respiratory infections. But with that success accompanies the growth of non-communicable diseases and risk factors such as tobacco use and high blood pressure, which could overwhelm the health system...
Strong FDA Review Requires Conflict-Of-Interest Restrictions
Date: Jun-10-2013A 2012 law that loosened conflict-of-interest restrictions for FDA advisory panels could weaken the agency's review system and could allow more drugs with safety problems to gain market approval, says a new analysis published in Science by researchers at the George Washington University School of Public Health and Health Services (SPHHS). The 2012 legislation removed measures put in place by an earlier law passed in 2007, according to the report by Susan F. Wood, PhD, an associate professor of health policy at SPHHS and Jillian K...
Immune Regulation Of Ovarian Development: Programming By Neonatal Immune Challenge
Date: Jun-10-2013Bacterial infections during early life, such as Chlamydia which is present in 15% of newly born babies, may reduce reproductive success in adult women. For example, exposure to bacteria can lead to a change in the onset of puberty, as well as in ovarian morphology and sexual behavior...
The Swing Of Architect Genes
Date: Jun-10-2013A few days. This is the short period of time during which our body's construction plan is put in place, during its embryonic life. The appearance of limbs and vertebrae is orchestrated by a family of 'architect' genes called Hox, each providing precise instructions at a given time...
Immune Cells Deprived Of Sugar By Tumors
Date: Jun-10-2013Cancer cells' appetite for sugar may have serious consequences for immune cell function, researchers at Washington University School of Medicine in St. Louis have learned. The scientists found that when they kept sugar away from critical immune cells called T cells, the cells no longer produced interferon gamma, an inflammatory compound important for fighting tumors and some kinds of infection. "T cells can get into tumors, but unfortunately they are often ineffective at killing the cancer cells," said Erika Pearce, PhD, assistant professor of pathology and immunology...
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