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Aspirin For Primary Prevention Of Heart Attacks In Men: Eligibility Increases When Cancer Mortality Benefit Added
Date: Jun-10-2013While aspirin has been shown to be effective in preventing heart attacks in men, it also increases the risk of gastrointestinal bleeding and possibly stroke, even at low doses. As such, national guidelines suggest that aspirin be used for prevention only in men at higher risk for cardiovascular events, so that the benefits of aspirin are greater than its adverse effects. Recent data suggest that aspirin may also be effective for reducing cancer deaths...
Structural And Molecular Differences Between Human Argonaute Proteins Reveal Essential Elements For RNA-Slicing
Date: Jun-10-2013Human Argonautes (hAgo), are key proteins involved in a process known as RNA interference. RNAi, as it is often called, is a mechanism that cells use to regulate gene expression. Human Argonaute-2 (hAgo2) is known as "slicer" for its unique ability among the 4 human Argonaute proteins to directly cut messenger RNA -- which carries the information coded in genomic DNA to make a protein -- and thus disable "messages" generated from genes. The atomic resolution structure of hAgo2 solved previously, revealed the active site, a region of the enzyme that is key to its slicing activity...
The Biology Behind Restless Leg Syndrome
Date: Jun-10-2013A protein profile of people with restless leg syndrome (RLS), identifies factors behind disrupted sleep, cardiovascular dysfunction and pain finds research in BioMed Central's open access journal Fluids and Barriers of the CNS. The research gives insights into the disorder, and could be useful in the development of new treatments. It is not completely clear what causes RLS, also known as Willis Ekbom disease (WED), but in some people it is associated with iron deficiency in the brain, kidney failure, or low levels of the ' pleasure' neurotransmitter dopamine...
Food-Secure Families' Preschoolers Have Distorted View Of Healthy Food When Parents Are Heavy TV Viewers
Date: Jun-10-2013If your preschooler thinks a cheeseburger is healthy, you may want to reconsider how you watch TV. A recent study by researchers at the University of Michigan found commercial TV viewing, as opposed to commercial-free digitally recorded TV or other media without food advertising, in the home was related to greater junk food consumption. Kristen Harrison and Mericarmen Peralta, both of the University of Michigan, will present their findings at the 63rd Annual International Communication Association conference in London...
How A Genetic Duplication That Occurred Millions Of Years Ago Encouraged The Evolution Of The ASF1b Gene, Involved In Cancer Development
Date: Jun-10-2013How and when evolution generates diversity or gives form to proteins, living beings' functional building blocks, are essential questions that still surround the theory of evolution. In humans, the majority of genes have emerged via genetic duplication, a strategy in which a gene generates two identical copies that can evolve to generate different proteins...
No Added Benefit Of Ingenol Mebutate For Actinic Keratosis
Date: Jun-10-2013Manufacturer's dossier did not contain any relevant data for the comparison with diclofenac/hyaluronic acid gel The drug ingenol mebutate (trade name: Picato) has been approved in Germany since November 2012 as a gel for the treatment of certain forms of actinic keratosis in adults. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG) the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether this new drug offers an added benefit over diclofenac/hyaluronic acid gel...
Dapagliflozin For Diabetes: No Added Benefit Proven
Date: Jun-10-2013Manufacturer's dossier did not contain suitable data for any therapeutic indication Dapagliflozin (trade name: Forxiga) has been approved in Germany since November 2012 for the treatment of type 2 diabetes mellitus. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG) the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether this new drug offers an added benefit over the current standard therapy...
Pioneering Study Demonstrates Benefit Of Imaging Technique In Identifying Bipolar Disorder
Date: Jun-10-2013MRI may be an effective way to diagnose mental illnesses such as bipolar disorder, according to experts from the Icahn School of Medicine at Mount Sinai. In a landmark study using advanced techniques, the researchers were able to correctly distinguish bipolar patients from healthy individuals based on their brain scans alone. The data are published in the journal Psychological Medicine. Currently, most mental illnesses are diagnosed based on symptoms only, creating an urgent need for new approaches to diagnosis...
New Surgical Technique For Deep Brain Stimulation Proves Accurate And Safe
Date: Jun-10-2013The surgeon who more than two decades ago pioneered deep brain stimulation surgery in the United States to treat people with Parkinson's disease and other movement disorders has now developed a new way to perform the surgery - which allows for more accurate placement of the brain electrodes and likely is safer for patients. The success and safety of the new surgical technique could have broad implications for deep brain stimulation, or DBS, surgery into the future, as it may increasingly be used to help with a wide range of medical issues beyond Parkinson's disease and familial tremors...
Analyzing Soil Lead In Urban Garden Plots
Date: Jun-10-2013The local food movement is gaining traction in cities across America, with urban gardens contributing a healthy source of fresh produce for local citizens as well as providing a social outlet for gardeners and creating open spaces for residents to enjoy. Urban gardening is not without risks, however. Many garden plots within cities were previously inhabited by residences or industrial buildings that disposed of toxic chemicals on site, creating potential health hazards from the use of lead in paint, gasoline and industrial activities...
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