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Understanding What Goes Wrong In Alzheimer's Disease - Preventing 'Traffic Jams' In Brain Cells
Date: May-30-2013An Alzheimer's disease protein controls the speed at which materials move through brain cells, and defects could lead to deadly pileups of the kind seen in neurodegenerative disease, a new publication finds Imagine if you could open up your brain and look inside. What you would see is a network of nerve cells called neurons, each with its own internal highway system for transporting essential materials between different parts of the cell...
Nanoparticles That Shape-Shift Flip From Sphere To Net In Response To Tumor Signal
Date: May-30-2013Scientists at the University of California, San Diego, have designed tiny spherical particles to float easily through the bloodstream after injection, then assemble into a durable scaffold within diseased tissue. An enzyme produced by a specific type of tumor can trigger the transformation of the spheres into netlike structures that accumulate at the site of a cancer, the team reports in the journal Advanced Materials this week...
Targeting Cancer Cells Without Typical Side Effects Using New Ruthenium Complexes
Date: May-30-2013A team of UT Arlington researchers has identified two ruthenium-based complexes they believe could pave the way for treatments that control cancer cell growth more effectively and are less toxic for patients than current chemotherapies. Fred MacDonnell, professor of chemistry and biochemistry at The University of Texas at Arlington, has been researching a new generation of metal-based antitumor agents along with a team from the City of Hope Comprehensive Center Center in Duarte, Calif. Their aim is to find new therapies to complement widely used platinum-based therapies, such as cisplatin...
How Parents And Peers Can Help Curb The Increasing Problem Of Prescription Drug Abuse Among Youth
Date: May-30-2013Young people are increasingly turning to prescription drugs to get high. Research out of the University of Cincinnati sheds new light on what could increase or lower that risk. The research by Keith King, a University of Cincinnati professor of health promotion; Rebecca Vidourek, a UC assistant professor of health promotion; and Ashley Merianos, a graduate assistant in health promotion, is published in the current issue of the Journal of Primary Prevention...
Adult Wild Chimpanzees Have Developed A Certain Immunity Against Malaria Parasites
Date: May-30-2013Wild great apes are widely infected with malaria parasites. Yet, nothing is known about the biology of these infections in the wild. Using faecal samples collected from wild chimpanzees, an international team of researchers from the Max Planck Institute for Evolutionary Anthropology in Leipzig and the Robert Koch Institute in Berlin has now investigated the effect of the animals' age on malaria parasite detection rates. The data show a strong association between age and malaria parasite positivity, with significantly lower detection rates in adult chimpanzees...
Down Syndrome Neurons Grown From Stem Cells Show Signature Problems
Date: May-30-2013Down syndrome, the most common genetic form of intellectual disability, results from an extra copy of one chromosome. Although people with Down syndrome experience intellectual difficulties and other problems, scientists have had trouble identifying why that extra chromosome causes such widespread effects. In new research published this week, Anita Bhattacharyya, a neuroscientist at the Waisman Center at the University of Wisconsin-Madison, reports on brain cells that were grown from skin cells of individuals with Down syndrome...
Inexpensive Biomedical And Diagnostic Devices Based On Advanced Paper
Date: May-30-2013Paper is known for its ability to absorb liquids, making it ideal for products such as paper towels. But by modifying the underlying network of cellulose fibers, etching off surface "fluff" and applying a thin chemical coating, researchers have created a new type of paper that repels a wide variety of liquids - including water and oil. The paper takes advantage of the so-called "lotus effect" - used by leaves of the lotus plant - to repel liquids through the creation of surface patterns at two different size scales and the application of a chemical coating...
Engineered Stem Cell Advance Points Toward Treatment For ALS
Date: May-30-2013Transplantation of human stem cells in an experiment conducted at the University of Wisconsin-Madison improved survival and muscle function in rats used to model ALS, a nerve disease that destroys nerve control of muscles, causing death by respiratory failure. ALS (amyotrophic lateral sclerosis) is sometimes called "Lou Gehrig's disease." According to the ALS Association, the condition strikes about 5,600 Americans each year. Only about half of patients are alive three years after diagnosis...
Stem Cells Improve Function In Newly-Paralyzed Rats
Date: May-30-2013Neuralstem's Cells Induce Improvement In Acute Spinal Cord Injury Rats, UCSD Study Shows Neuralstem, Inc. (NYSE MKT: CUR) announced that a paper published today in the journal, STEM CELL RESEARCH AND THERAPY, showed that rats transplanted with its spinal cord-derived human neural stem cells, NSI-566, three days after a spinal cord injury at L3 (lumbar 3), showed improvement along several measures of motor function and a reduction of spasticity...
High Global Burden Of Oral Conditions - 3.9 Billion Affected
Date: May-30-2013The International and American Associations for Dental Research (IADR/AADR) have published a paper titled "Global Burden of Oral Conditions in 1990-2010: A Systemic Analysis." The paper, written by lead author Wagner Marcenes, Queen Mary University, London, is published in the IADR/AADR Journal of Dental Research. The "Global Burden of Disease Study 2010 (GBD 2010)" produced comparable estimates of the burden of 291 diseases and injuries in 1990, 2005 and 2010...
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