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Schizophrenics To Benefit From Study Of Normal People Who Hear Voices
Date: May-28-2013Researchers from the Bergen fMRI Group at the University of Bergen (UiB) are working on how to help schizophrenics, who hear voices. The way they do this is by studying people who also hear voices, but who do not suffer from a mental illness. For a five-year period, the group is studying the brain processes causing people to hear voices. A recent report published in Frontiers in Human Neuroscience shows some of the group's startling results...
New Animal Model Offers Insights Into Mechanisms Of Parkinson's Disease Pathogenesis
Date: May-28-2013In Parkinson's disease, the protein "alpha-synuclein" aggregates and accumulates within neurons. Specific areas of the brain become progressively affected as the disease develops and advances. The mechanism underlying this pathological progression is poorly understood but could result from spreading of the protein (or abnormal forms of it) along nerve projections connecting lower to upper brain regions...
Immune Cell Activation In Multiple Sclerosis
Date: May-28-2013Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to examine individual cells and their activity directly in the tissue. The development of new microscopes and fluorescent dyes in recent years has brought this scientific dream tantalisingly close. Scientists from the Max Planck Institute of Neurobiology in Martinsried have now presented not one, but two studies introducing new indicator molecules which can visualise the activation of T cells...
Making Breast Cancer Cells More Responsive To Chemotherapy
Date: May-28-2013Breast cancer characterized as "triple negative" carries a poor prognosis, with limited treatment options. In some cases, chemotherapy doesn't kill the cancer cells the way it's supposed to. New research from Western University explains why some cancer cells don't respond to chemotherapy, and identifies a mechanism to rectify that. Dr...
Hot Flashes In Menopause Related To Memory Problems
Date: May-28-2013Don't doubt it when a woman harried by hot flashes says she's having a hard time remembering things. A new study published online in Menopause, the journal of The North American Menopause Society (NAMS), helps confirm with objective tests that what these women say about their memory is true. In the past, some studies showed that hot flashes were related to memory problems, and some didn't. Other studies showed that, even though there was a relationship between hot flashes and what women said about memory problems, objective tests didn't confirm it...
Bexarotene Should Not Be Tested On Patients With Alzheimer's Disease
Date: May-28-2013Approximately a year ago, the leading journal Science published an article about bexarotene as a potential Alzheimer's drug. A significant breakthrough and an important starting point for further Alzheimer's research. The research group of Bart De Strooper - Alzheimer's researcher at VIB and KU Leuven - in collaboration with the group of Rudi D'Hooge - KU Leuven - and scientists at Janssen Pharmaceutica, Beerse, also tested this candidate drug in various Alzheimer's animal test models. Their results were different, as were those of two American study groups...
New Method Provides Significant Improvement In The Detection Of HIV Antibodies
Date: May-28-2013Detection of HIV antibodies is used to diagnose HIV infection and monitor trials of experimental HIV/AIDS vaccines. New, more sensitive detection systems being developed use microspheres to capture HIV antibodies and can measure even small amounts of multiple antibodies at one time. This novel multiplex immunoassay approach is described in an article in BioResearch Open Access, a peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available on the BioResearch Open Access website...
News From The Journal Of Clinical Investigation: May 24, 2013
Date: May-28-2013Malnutrition exacerbates Giardia infection in mice Giardia is a common parasite that frequently infects young children in the developing world. It is commonly encountered through contaminated food, soil, or water. The parasite lives inside the intestines and can cause severe diarrhea and other gastrointestinal problems and Giardia infection has been associated with developmental growth delays. Because the majority of infected individuals do not experience symptoms and frequently are infected with other pathogens, it is unclear if endemic Giardia directly stunts growth...
Combating Metastatic Cancer Through Immune System Modulation
Date: May-28-2013Cancer cells spread and grow by avoiding detection and destruction by the immune system. Stimulation of the immune system can help to eliminate cancer cells; however, there are many factors that cause the immune system to ignore cancer cells. Regulatory T cells are immune cells that function to suppress the immune system response. In this issue of the Journal of Clinical Investigation, researchers led by Ronald Levy at Stanford University found that regulatory T cells that infiltrate tumors express proteins that can be targeted with therapeutic antibodies...
Multicolor Fluorescence Labeling Method Offers Hope For Cancer Diagnosis
Date: May-28-2013In recent years, microRNAs (miRNAs) and other non-coding RNAs are small molecules that help control the expression of specific proteins. In recent years they have emerged as disease biomarkers. miRNA profiles have been used to establish tissue origin for cancers of unknown primary origin, determine prognosis, monitor therapeutic responses and screen for disease, but clinically tractable, diagnostic methods for monitoring miRNA expression in patient samples are not currently available...
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