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Biogen Idec Submits Application To FDA For Approval Of Plegridy™ (Peginterferon Beta-1a) In Multiple Sclerosis
Date: May-23-2013EMA Submission Planned in the Coming Weeks Biogen Idec (NASDAQ: BIIB) has announced it has submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for approval of PLEGRIDY™ (peginterferon beta-1a), the company's pegylated subcutaneous injectable candidate for relapsing forms of multiple sclerosis (RMS). This regulatory submission was based on the results from the first year of the two-year global Phase 3 ADVANCE study...
Children Exposed To Secondhand Smoke Likely To Be More Aggressive
Date: May-23-2013Children who are exposed to secondhand smoke in early childhood are more likely to grow up to physically aggressive and antisocial, regardless of whether they were exposed during pregnancy or their parents have a history of being antisocial, according to Linda Pagani and Caroline Fitzpatrick of the University of Montreal and its affiliated CHU Sainte-Justine hospital. No study to date has controlled for these factors. "Secondhand smoke is in fact more dangerous that inhaled smoke, and 40% of children worldwide are exposed to it...
COPD Patients Benefit From Antibiotic Therapy
Date: May-23-2013Extended use of a common antibiotic may prolong the time between hospitalizations for patients suffering from chronic obstructive pulmonary disease (COPD), according to a post-hoc analysis of a multicenter study which compared the hospitalization rates of patients treated with a 12-month course of azithromycin to the rates of those treated with placebo. The results of the current analysis were presented at the ATS 2013 International Conference...
Sleep Quality And School Performance Impaired By Asthma Symptoms
Date: May-23-2013The negative effects of poorly controlled asthma symptoms on sleep quality and academic performance in urban schoolchildren has been confirmed in a new study...
Improving Physical Activity Levels Benefits COPD Patients
Date: May-23-2013Clinical measurement of physical activity appears to be an independent predictor of whether or not patients with chronic obstructive pulmonary disease (COPD) will end up being hospitalized, according to a new study conducted by researchers in Connecticut. The study also corroborates an earlier investigation that linked higher levels of inactivity with an increased incidence of hospitalizations among patients with COPD. The results of the study were presented at the ATS 2013 International Conference...
Heart Condition Induced By Stress, Anxiety, Treated With Antidepressant
Date: May-23-2013A drug commonly used to treat depression and anxiety may improve a stress-related heart condition in people with stable coronary heart disease, according to researchers at Duke Medicine. Compared with those receiving placebo, people who took the antidepressant escitalopram (sold as Lexapro) were more than two-and-a-half times less likely to have mental stress-induced myocardial ischemia (MSIMI), a heart condition brought on by mental stress...
Antibiotic Resistance And The Immune System
Date: May-23-2013Bacteria resistant to the antibiotic colistin are also commonly resistant to antimicrobial substances made by the human body, according to a study in mBio®, the online open-access journal of the American Society for Microbiology. Cross-resistance to colistin and host antimicrobials LL-37 and lysozyme, which help defend the body against bacterial attack, could mean that patients with life-threatening multi-drug resistant infections are also saddled with a crippled immune response...
Early Identification And Treatment Of Postpartum Depression Can Limit Or Prevent Debilitating Effects
Date: May-23-2013The epigenetic modifications, which alter the way genes function without changing the underlying DNA sequence, can apparently be detected in the blood of pregnant women during any trimester, potentially providing a simple way to foretell depression in the weeks after giving birth, and an opportunity to intervene before symptoms become debilitating. The findings of the small study involving 52 pregnant women are described online in the journal Molecular Psychiatry. "Postpartum depression can be harmful to both mother and child," says study leader Zachary Kaminsky, Ph.D...
Computational Model Evaluates A New Way To Open Clogged Arteries
Date: May-23-2013Over the past few decades, scientists have developed many devices that can reopen clogged arteries, including angioplasty balloons and metallic stents. While generally effective, each of these treatments has drawbacks, including the risk of side effects. A new study from MIT analyzes the potential usefulness of a new treatment that combines the benefits of angioplasty balloons and drug-releasing stents, but may pose fewer risks...
Shigella Uses Natural 'Thermometer' To Trigger Diarrheal Disease
Date: May-23-2013How does the bacterium Shigella - the cause of a deadly diarrheal disease - detect that it's in a human host? Ohio University scientists have found that a biological "RNA thermometer" monitors whether the environment is right for the bacterium to produce the factors it needs to survive within the body, according to a study published in the journal PLOS ONE. The scientists have been seeking more information about the genetic pathways of Shigella in the hope of finding new treatment options for the disease it causes...
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