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Scientists Identify Early Predictors Of Disease Progression Which Could Speed Huntington's Disease Drug Trials
Date: May-14-2013Scientists have identified a set of tests that could help identify whether and how Huntington's disease (HD) is progressing in groups of people who are not yet showing symptoms. The latest findings from the TRACK-HD study*, published Online First in The Lancet Neurology, could be used to assess whether potential new treatments are slowing the disease up to 10 years before the development of noticeable symptoms. "Currently, the effectiveness of a new drug is decided by its ability to treat symptoms...
Air Pollution Increases Risk Of Insulin Resistance In Children
Date: May-14-2013New research shows that growing up in areas where air pollution is increased raises the risk of insulin resistance (the prescursor to diabetes) in children. The research is published in Diabetologia, the journal of the European Association for the Study of Diabetes (EASD), and is by Elisabeth Thiering and Joachim Heinrich, Helmholtz Zentrum München, Neuherberg, Germany, and colleagues. Previous studies have identified links between air pollution and other chronic conditions such as atherosclerosis and heart disease...
The Lancet Series On Bipolar Disorder: Advances In Biological Understanding Need To Be Brought Closer To The Experience Of The Patient
Date: May-14-2013Bipolar disorder - where patients experience recurrent episodes of mood disturbance, ranging from extreme elation (mania) to severe depression - is thought to affect roughly 2% of the world's population in its most pronounced forms (bipolar I and II), with milder forms of the disorder affecting another 2%. A new Lancet Series provides a comprehensive overview of the genetics, diagnosis, and treatment of bipolar disorder, outlining future challenges, and debating imminent changes to the criteria that psychiatrists use to diagnose the illness...
60 Years Of Data Suggest A Link Between Obesity And Height In Childhood And Endometrial Cancer In Adulthood
Date: May-14-2013New research presented at the European Congress in Liverpool (ECO) beginning today (Sunday 12 May) shows a possible link between obesity and height in childhood and endometrial cancer in adulthood. The research* is by Julie Aarestrup, Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark, and colleagues. Endometrial cancer is in Europe the fourth most common cancer in women with more than 90,000 new cases diagnosed each year...
Hearing, Vision Loss And Kidney Disease May Be Impacted By Cilia Research
Date: May-14-2013Experiments at Johns Hopkins have unearthed clues about which protein signaling molecules are allowed into hollow, hair-like "antennae," called cilia, that alert cells to critical changes in their environments. Researchers found that the size limit for entry is much greater than previously thought, allowing most of a cell's proteins into cilia. The researchers believe that the specific collection of proteins in each cilium, customized to the needs of each cell type, is determined by whether and how cilia keep proteins inside once they enter - not which ones they allow in initially...
New Global Surveillance Tool Detects And Monitors Public Concerns About Vaccines In Real Time And Could Help Boost Vaccine Uptake
Date: May-14-2013Scientists have developed a global media surveillance system that enables them to look for, and systematically monitor, up-to-the-minute public concerns and rumours about vaccines originating from 144 countries. The application could help public health officials respond more quickly and effectively to a loss of public confidence in vaccines before it results in vaccination refusals and disease outbreaks, according to an Article published Online First in The Lancet Infectious Diseases...
Syndax Pharmaceutical To Commercialize First-in-Class Lung Cancer Treatment Developed At The University Of Colorado
Date: May-14-2013Licensing agreement allows development of a novel combination therapeutic for non-small-cell lung carcinoma, a type of lung cancer difficult to treat with conventional chemotherapy. The University of Colorado (CU) has signed an exclusive, worldwide licensing agreement with Syndax Pharmaceuticals, a company focused on the development of novel combination strategies for cancers that have become resistant to standard treatments...
Infants Born To Vaccinated Mothers May Lose Initial Measles Immunity Sooner Than Those Born To Unvaccinated Mothers
Date: May-14-2013Dutch study findings support earlier vaccination of newborns at high risk for measles A new Dutch study suggests that infants born to mothers who received the measles-mumps-rubella (MMR) vaccine lose their initial immunity to measles--acquired from their mothers--sooner than infants born to mothers who were naturally infected with measles...
4 New Genetic Risk Factors Identified For Testicular Cancer
Date: May-14-2013A new study looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. The findings from this first-of-its-kind meta-analysis were reported online in Nature Genetics by researchers at the Perelman School of Medicine at the University of Pennsylvania...
Defects In Developmental Pathway Associated With Congenital Condition Of Heart-Lung Connection Or Blue-Baby Syndrome
Date: May-14-2013Total anomalous pulmonary venous connection (TAPVC), one type of "blue baby" syndrome, is a potentially deadly congenital disorder that occurs when pulmonary veins don't connect normally to the left atrium of the heart. This results in poorly oxygenated blood throughout the body, and TAPVC babies are born cyanotic - blue-colored - from lack of oxygen. TAPVC is usually detected in newborns when babies are blue despite breathing normally. Life-threatening forms of the disorder are rare - about 1 in 15,000 live births...
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