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Molecular Messages Decoded That Tell Prostate And Breast Cancers To Spread
Date: May-02-2013Cancer cells are wily, well-traveled adversaries, constantly side-stepping treatments to stop their spread. But for the first time, scientists at the University of Michigan have decoded the molecular chatter that ramps certain cancer cells into overdrive and can cause tumors to metastasize throughout the body. Researchers have long known that tumors recruit healing cells, which is a major reason why cancer is so difficult to thwart. This is the first known study to explain the molecular behavior behind the series of changes that happen in the healing cells that result in metastasis...
Most Patients Colonized By C. difficile Could Be Identified By Screening At Hospital Admission
Date: May-02-2013Testing patients with just three risk factors upon hospital admission has potential to identify nearly three out of four asymptomatic carriers of C. difficile, according to a new study published in the May issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC). Researchers from Mayo Clinic in Rochester, MN, analyzed stool samples from 320 patients showing no symptoms of C. difficile at hospital admission using a real-time polymerase chain reaction (PCR) assay...
Endoscopic Treatment For Zenker's Diverticulum Is Safe Long-Term
Date: May-02-2013A new study reports that flexible endoscopic treatment of Zenker's diverticulum by using a diverticuloscope offers a treatment modality with a very low complication rate. Zenker's diverticulum is an abnormal pouch in the upper part of the esophagus that causes difficulty swallowing and is most commonly found in older patients. Clinical remission was achieved over a single session of treatment in the majority of the cases. This study also demonstrated the long-term efficacy of the technique...
Mortality Of Severe Acute Kidney Injury Patients Improved By Nephrologist Follow-Up
Date: May-02-2013Patients with acute kidney injury who see a nephrologist within 90 days of being discharged from a hospital have a 24 per cent lower risk of dying than those who do not see a kidney specialist, a new study has found. The benefit of seeing a nephrologist was most pronounced in individuals who had not previously seen a nephrologist, and likely had new onset kidney disease, according to the study by Dr. Ziv Harel of St. Michael's Hospital. The study appears in the May issue of the journal Kidney International...
Compounds That Stimulate The Cannabinoid Type 2 Receptor In White Blood Cells Can Weaken HIV-1 Infection
Date: May-02-2013A new use for compounds related in composition to the active ingredient in marijuana may be on the horizon: a new research report published in the Journal of Leukocyte Biology shows that compounds that stimulate the cannabinoid type 2 (CB2) receptor in white blood cells, specifically macrophages, appear to weaken HIV-1 infection. The CB2 receptor is the molecular link through which the pharmaceutical properties of cannabis are manifested...
Women Who Drink Alcohol Before Pregnancy Less Likely To Take Multivitamins
Date: May-02-2013Researchers from the University of California, San Diego Department of Pediatrics and Rady Children's Hospital-San Diego, a research affiliate of UC San Diego School of Medicine, have found a link between multivitamin use and alcohol consumption before pregnancy, uncovering a need for education about the importance of vitamin supplementation, particularly among women who drink alcohol during their childbearing years. The study was published online this month in Alcoholism: Clinical and Experimental Research...
Vitamin B2 May Be An Antidote To Cyanide Poisoning
Date: May-02-2013With the remains of a recent lottery winner having been exhumed for foul play related to cyanide poisoning, future winners might wonder what they can do to avoid the same fate. A new report in The FASEB Journal involving zebrafish suggests that riboflavin, also known as vitamin B2, may mitigate the toxic effects of this infamous poison. In addition, the report shows that zebrafish are a viable model for investigating the effects of cyanide on humans. As with any research involving animal models, these findings are preliminary until thoroughly tested in clinical trials...
Scientists Compare Novel Coronavirus To SARS Coronavirus
Date: May-02-2013NIH-supported scientists used lab-grown human lung cells to study the cells' response to infection by a novel human coronavirus (called nCoV) and compiled information about which genes are significantly disrupted in early and late stages of infection. The information about host response to nCoV allowed the researchers to predict drugs that might be used to inhibit either the virus itself or the deleterious responses that host cells make in reaction to infection...
Lung Cancer Survival Improved By Chemo, Radiation, Then Surgery
Date: May-02-2013In one of the largest observational studies of its kind, researchers report that a combination of chemotherapy and radiation followed by surgery in patients with stage 3 non-small cell lung cancer improves survival. Patients who had chemoradiation therapy followed by surgery had twice the five-year survival rate of those who had only chemoradiation, says Dr. Matthew Koshy, a radiation oncologist at the University of Illinois Hospital & Health Sciences System and lead author of the study...
Therapeutic Proteins Could Offer Much Needed Treatment Strategy For Metastatic Cancer
Date: May-02-2013Cancer spread or metastasis can strike unprecedented fear in the minds of cancer patients. The "seed and the soil" hypothesis proposed by Stephen Paget in 1889 is now widely accepted to explain how cancer cells (seeds) are able to generate fertile soil (the microenvironment) in distant organs that promotes cancer's spread. However, this concept does not explain why some tumors do not spread or metastasize...
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