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How Turning Down Synthesis Of A Protein Improves Nerve, Muscle Function In Common Neuropathy
Date: Apr-30-2013A potential new treatment strategy for patients with Charcot-Marie-Tooth disease is on the horizon, thanks to research by neuroscientists now at the University at Buffalo's Hunter James Kelly Research Institute and their colleagues in Italy and England. The institute is the research arm of the Hunter's Hope Foundation, established in 1997 by Jim Kelly, Buffalo Bills Hall of Fame quarterback, and his wife, Jill, after their infant son Hunter was diagnosed with Krabbe Leukodystrophy, an inherited fatal disorder of the nervous system. Hunter died in 2005 at the age of eight...
Challenges Faced By Adolescent And Young Adult Cancer Survivors
Date: Apr-30-2013New research out of the George Washington University Cancer Institute (GWCI) focuses on the difficulties of transitioning to adulthood while dealing with the long-term and late effects of cancer and its treatment. The study was recently published in the Journal of Oncology Navigation and Survivorship, titled "Improving Cancer Survivorship for Adolescents and Adults." Based on information obtained at GWCI's second Cancer Survivorship Research Symposium, the paper summarizes the discussion amongst cancer survivors, caregivers, researchers, clinicians and other healthcare professionals...
Combined Liver-Kidney Transplantation May Benefit Some Patients With Complicated Childhood Polycystic Kidney Disease
Date: Apr-30-2013A collaborative team of physician-scientists at the Medical College of Wisconsin (MCW) and Children's Hospital of Wisconsin Research Institute has developed a new evidence-based, clinical algorithm to help physicians treat complex patients with autosomal recessive polycystic kidney disease (ARPKD). Their invited manuscript, written by Grzegorz Telega, M.D., associate professor of pediatrics (gastroenterology and hepatology) at MCW and program director of hepatology at Children's Hospital of Wisconsin; David Cronin, II, M.D., Ph.D...
Collaboration Of Researchers In The Physical And Biological Sciences Target Metastatic Cancer
Date: Apr-30-2013Cancer cells that can break out of a tumor and invade other organs are more aggressive and nimble than nonmalignant cells, according to a new multi-institutional nationwide study. These cells exert greater force on their environment and can more easily maneuver small spaces. The researchers report in the journal Scientific Reports that a systematic comparison of metastatic breast-cancer cells to healthy breast cells revealed dramatic differences between the two cell lines in their mechanics, migration, oxygen response, protein production and ability to stick to surfaces...
Student Researchers Get A New View Of The Dynamics Of Cancer Cells As They Metastasize
Date: Apr-30-2013A team of student researchers and their professors from 20 laboratories around the country have gotten a new view of cancer cells. The work could shed light on the transforming physical properties of these cells as they metastasize, said Jack R. Staunton, a Ph.D. candidate at Arizona State University in the lab of Prof. Robert Ros, and the lead author of a paper reporting on the topic. Metastasis is a critical step in the progression of cancer. It is when the cancer spreads from one organ or part to another...
How The Brain Folds To Fit During Fetal Development
Date: Apr-30-2013During fetal development of the mammalian brain, the cerebral cortex undergoes a marked expansion in surface area in some species, which is accommodated by folding of the tissue in species with most expanded neuron numbers and surface area. Researchers have now identified a key regulator of this crucial process. Different regions of the mammalian brain are devoted to the performance of specific tasks. This in turn imposes particular demands on their development and structural organization...
Scientists Hope To Improve Genome-Wide Association Studies With 2 New Methods
Date: Apr-30-2013As scientists probe and parse the genetic bases of what makes a human a human (or one human different from another), and vigorously push for greater use of whole genome sequencing, they find themselves increasingly threatened by the unthinkable: Too much data to make full sense of...
Intermittent Fasting Shown To Improve Diabetes And Reduce Cardiovascular Risk
Date: Apr-30-2013Intermittent fasting is all the rage, but scientific evidence showing how such regimes affect human health is not always clear cut. Now a scientific review in the British Journal of Diabetes and Vascular Disease published by SAGE, suggests that fasting diets may help those with diabetes and cardiovascular disease, alongside established weight loss claims. Intermittent fasting - fasting on a given number of consecutive or alternate days - has recently been hailed as a path to weight loss and improved cardiovascular risk...
The Immune Protein C4BP Shows Potential As A Transporter For Drugs
Date: Apr-30-2013The protein C4BP is similar to a spider in its spatial form with eight "arms". The structure of the "spider body" has recently been described in detail by researchers from the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Technische Universitat Darmstadt. This leads the scientists to unconventional ideas - the protein is possibly suitable as a scaffold for the transport of active pharmaceutical substances, particularly biomolecules. The researchers are publishing their results in the current edition of the international journal Journal of Molecular Biology...
The Potentially Fatal Combination Of Flu And Bacteria
Date: Apr-30-2013Scientists from the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna have provided insights into how much harm bacteria can cause to the lungs of people with the flu. An infection with both the flu and bacteria can be a fatal combination. The results could prompt the development of alternative treatments for flu-related bacterial infections, to improve patient outcome and prevent permanent lung damage. The study is published in the renowned journal Science...
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