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Hope For New Tailor-Made Anti-Cancer Agents
Date: Apr-23-2013Scientists at the Walter and Eliza Hall Institute and their collaborators have tailor-made a new chemical compound that blocks a protein that has been linked to poor responses to treatment in cancer patients. The development of the compound, called WEHI-539, is an important step towards the design of a potential new anti-cancer agent. WEHI-539 has been designed to bind and block the function of a protein called BCL-XL that normally prevents cells from dying. The death and elimination of abnormal cells in the body is an important safeguard against cancer development...
New Strategies For Understanding And Treating Pulmonary Fibrosis Suggested By Genome Study
Date: Apr-23-2013A new genome-wide association study of more than 6,000 people has identified seven new genetic regions associated with pulmonary fibrosis. In findings published online in Nature Genetics, researchers at National Jewish Health, the University of Colorado and several other institutions found a number of genes associated with host defense, cell-cell adhesion and DNA repair, which provide clues to possible mechanisms underlying this currently untreatable disease...
Risk For Rheumatoid Arthritis Increased By Smoking
Date: Apr-23-2013Number of cigarettes smoked a day and the number of years a person has smoked both increase the risk of rheumatoid arthritis (RA), finds research in BioMed Central's open access journal Arthritis Research & Therapy. The risk decreases after giving up smoking but, compared to people who have never smoked, this risk is still elevated 15 years after giving up. Researchers from the Karolinska Institutet and Karolinska University Hospital analysed data from the Swedish Mammography Cohort, which included 34,000 women aged between 54 and 89, 219 of which had RA...
Researchers Have Deciphered The Underlying Mechanism Of An Antiviral Drug
Date: Apr-23-2013A long-forgotten candidate for antiviral therapy is undergoing a renaissance: Since the 1970s, the small molecule CMA has been considered a potent agent against viral infections, yet it was never approved for clinical use. Scientists at the Bonn University Hospital have now deciphered how the molecule can actually stimulate the immune system to combat viruses. The results are now being presented in the journal of the European Molecular Biology Organization EMBO...
Relationship Defined Between Primary Sclerosing Cholangitis And Other Autoimmune Diseases
Date: Apr-23-2013Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16. Approximately 70 per cent of people who suffer from PSC also suffer from IBD. The team showed that only half of the newly associated genetic regions were shared with inflammatory bowel disease (IBD). For the first time, this definitively proves that PSC, although genetically related to IBD, is a distinct disease...
Women Who Give Birth As Teenagers More Likely To Become Overweight Or Obese Later In Life
Date: Apr-23-2013A new study debunks the myth that younger moms are more likely to "bounce back" after having a baby - teenage pregnancy actually makes women more likely to become obese. Women who give birth as teens are significantly more likely to be overweight or obese later in life than women who were not teen moms, University of Michigan Health System researchers found. The nationally representative study, which is the first believed to identify teen pregnancy as a predictor of obesity, appears in the American Journal of Obstetrics & Gynecology...
One Potential Medical Use For Algae - Edible Malarial Vaccine
Date: Apr-23-2013Can scientists rid malaria from the Third World by simply feeding algae genetically engineered with a vaccine? That's the question biologists at UC San Diego sought to answer after they demonstrated last May that algae can be engineered to produce a vaccine that blocks malaria transmission. In a follow up study, published online in the scientific journal Applied and Environmental Microbiology, they got their answer: Not yet, although the same method may work as a vaccine against a wide variety of viral and bacterial infections...
Despite Controversial USPSTF Recommendations, Mammogram Rates Have Not Declined
Date: Apr-23-2013More than three years after the United States Preventive Services Task Force (USPSTF) recommended against routine mammogram screening for women between the ages of 40 and 49, a study from Brigham and Women's Hospital (BWH) finds that mammogram rates in the United States have not declined in that age group, or any other. The study results are published in the online edition of the journal Cancer...
Largest Clinical Study Of Its Kind Finds Intense, Specialized Training In Young Athletes Linked To Serious Overuse Injuries
Date: Apr-23-2013Young athletes who specialize in one sport and train intensively have a significantly higher risk of stress fractures and other severe overuse injuries, even when compared with other injured athletes, according to the largest clinical study of its kind. For example, young athletes who spent more hours per week than their age playing one sport - such as a 12-year-old who plays tennis 13 or more hours a week - were 70 percent more likely to experience serious overuse injuries than other injuries. Loyola University Medical Center sports medicine physician Dr...
In Patients With Head And Neck Cancers, New Radiotherapy Approach Reduces Symptoms Of Dry Mouth
Date: Apr-23-2013Researchers have shown for the first time that it is possible to reduce the distressing symptoms of dry mouth in patients treated with radiotherapy for head and neck cancers if the radiation dose to a salivary gland (called the submandibular gland) on the opposite side to the tumour is kept to the minimum. The largest study yet to show a correlation between radiation doses to the submandibular glands and their output of saliva was presented at the 2nd Forum of the European Society for Radiotherapy and Oncology (ESTRO)...
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