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The Damaging Effect Of Cholesterol On The Brain And On Blood Vessels
Date: Apr-18-2013Researchers at the Linda Crnic Institute for Down Syndrome and the University of Colorado School of Medicine have found that a single mechanism may underlie the damaging effect of cholesterol on the brain and on blood vessels. High levels of blood cholesterol increase the risk of both Alzheimer's disease and heart disease, but it has been unclear exactly how cholesterol damages the brain to promote Alzheimer's disease and blood vessels to promote atherosclerosis...
Mouse Model Reveals Brain Development Guided By Junk DNA
Date: Apr-18-2013Specific DNA once dismissed as junk plays an important role in brain development and might be involved in several devastating neurological diseases, UC San Francisco scientists have found. Their discovery in mice is likely to further fuel a recent scramble by researchers to identify roles for long-neglected bits of DNA within the genomes of mice and humans alike. While researchers have been busy exploring the roles of proteins encoded by the genes identified in various genome projects, most DNA is not in genes...
Novel Therapeutic Targets Identified For Pulmonary Fibrosis
Date: Apr-18-2013A newly published study of patients with pulmonary fibrosis has discovered multiple genetic variations that should help with future efforts to treat the disease. Pulmonary fibrosis is a condition where lung tissue becomes thickened, stiff and scarred. Currently in the United States, there are no drugs approved for use in cases of the condition's most common and severe form, which is known as idiopathic pulmonary fibrosis (IPF) because the cause of the disease is not known...
Reformulated OxyContin To Receive Abuse-Deterrent Labelling
Date: Apr-17-2013A new reformulated form of Oxycontin (a highly addictive oxycodone hydrochloride) has received a unique labeling update by the U.S. Food and Drug Administration regarding its abuse potential. People most commonly abuse Oxycontin by injecting or snorting it. However, with Purdue Pharma L.P.'s new reformulated version, abuse is much harder. OxyContin abuse is a huge problem in the U.S. In 2011 only 7% of OxyContin users got their drug from their doctor while 13% bought it from a drug dealer...
Infant Mortality Rates Decline, USA
Date: Apr-17-2013After a 5-year plateau, the infant mortality rate in the USA dropped 12% from 2005 to the end of 2011, says a new "NCHS Data Brief" issued by the Centers for Disease Control and Prevention (CDC). Reductions for post-neonatal and neonatal mortality were similar. Infant mortality is a major indicator of the health of a country. The five leading causes of infant death in the USA account for 56% of all infant deaths; these include unintentional injuries, maternal complications, sudden infant death syndrome, congenital malformations, and short gestation/low birthweight...
Colic In Babies May Be Linked To Migraines Later In Life
Date: Apr-17-2013Colic has historically been described as a gastrointestinal issue, however, a new study suggests that migraines may play a role. The finding was published in the Journal of the American Medical Association and revealed that the likelihood was seven times higher that kids with migraines were previously colicky babies, compared to kids without migraines. Colic affects nearly one in five infants, according the U.S. National Library of Medicine. Usually babies with colic cry over three hours in a day, generally at the same time each day, three days a week...
Magnetic Brain Stimulation May Help Smokers Quit
Date: Apr-17-2013Smokers looking to quit cigarettes face an expanding choice of therapies to help them give up the habit, ranging from nicotine replacement medications and behavioral therapy, to hypnosis and even acupuncture. Now a new study from the US suggests another option: a treatment called high frequency transcranial magnetic stimulation (TMS) that stimulates nerve cells in the brain. More than 90% of attempts to quit smoking, the leading cause of preventable deaths globally, result in relapse, so the search for new cessation aids is ongoing...
The Solution To Your Gross-To-Net Problems, 17-18 June 2013, Boston, MA
Date: Apr-17-2013IIR's Gross-to-Net Accounting Forum will be here before you know it - seats are already filling up! Since its introduction, the buzz for this event has been building more and more each week, with positive feedback from our growing attendee list. We're very pleased to be able to bring you the focused content through in-depth case studies, to answer questions such as: Do I have the ability to ensure my Gross-to-Net calculations are accurate? With so many moving parts, it is difficult to guarantee GTN calculations will be 100% accurate...
Freezing Nerves, An Effective Way To Treat Chronic Pain
Date: Apr-17-2013A form of treatment called cyroneurolysis is being used for chronic pain caused by nerve damage; it involves using a tiny ball of ice to interrupt pain signals and eliminate pain while the nerves slowly recover. The results of the study, presented at the Society of Interventional Radiology's 38th Annual Scientific Meeting in New Orleans, could mean possible treatment for people suffering from a condition called neuralagia, characterized by a sharp shocking pain that follows the path of a nerve. William Moore, M.D...
Nanosponge Mops Up MRSA Toxin In Bloodstream
Date: Apr-17-2013Scientists in the US have developed tiny sponges made from nanoparticles disguised as red blood cells that can soak up a broad range of dangerous toxins in the blood, such as from bacteria like MRSA and E. coli, and even snake and bee venom. They suggest their technology, which so far has been shown to work in mice, offers a new way to remove toxins caused by a wide range of pathogens...
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