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Luminous Bacteria Control Clock Genes In Host's Body
Date: Apr-15-2013Another new study takes a further step toward revealing the pervasive influence microbial communities that inhabit plants and animals have on their biology. Scientists in the US have discovered that the luminous bacterium Vibrio fischeri regulates the daily rhythm of its host, the Hawaiian bobtail squid, by interacting with its clock genes. Margaret McFall-Ngai, of the University of Wisconsin-Madison (UW-Madison), and colleagues, report how they discovered the symbiotic bacterium setting the biological clock of its host, in the 2 April online issue of the journal mBio...
New Technique Holds Promise For The Treatment Of Multiple Sclerosis And Cerebral Palsy
Date: Apr-15-2013Researchers at Case Western Reserve School of Medicine have discovered a technique that directly converts skin cells to the type of brain cells destroyed in patients with multiple sclerosis, cerebral palsy and other so-called myelin disorders. This discovery appears in the journal Nature Biotechnology. This breakthrough now enables "on demand" production of myelinating cells, which provide a vital sheath of insulation that protects neurons and enables the delivery of brain impulses to the rest of the body...
Submicron NSAIDs Demonstrate Efficacy At Lower Doses In Studies In Patients With Acute And Chronic Pain
Date: Apr-15-2013Iroko Pharmaceuticals, LLC, a Philadelphia-based pharmaceutical company focused on the development and commercialization of innovative therapeutic products, is presenting positive Phase 3 data from its investigational submicron non-steroidal anti-inflammatory drug (NSAID) pipeline at two medical meetings. These presentations summarize the results of studies of lower dose submicron indomethacin in patients with post surgical pain, and lower dose submicron diclofenac in patients with osteoarthritis pain...
UK Allergy Sufferers Need More Support As They Grow Up, Study Finds
Date: Apr-15-2013Young people with severe allergies need help to live safely with their condition as they enter adulthood, a study has found. A survey of severe allergy sufferers aged 15 to 25 found that not all were receiving the specialist care they needed. Younger respondents were more likely to be given appropriate medical care - 34 per cent for those aged 15 to 18-years-old - compared with 23 per cent for over 18's, researchers found...
Lab-Grown Kidney Transplanted Into Rats Produces Urine
Date: Apr-15-2013US scientists have grown kidneys that produce rudimentary urine in the lab and also after being transplanted into rats. They hope to refine the approach so one day it is possible to grow human kidneys in the lab that work as well as donor kidneys in transplant patients but without the need for them to take drugs to suppress their immune system...
Toxins Released By Bacterial Infections And Venom Removed By Nanosponges
Date: Apr-15-2013Engineers at the University of California, San Diego have invented a "nanosponge" capable of safely removing a broad class of dangerous toxins from the bloodstream - including toxins produced by MRSA, E. coli, poisonous snakes and bees. These nanosponges, which thus far have been studied in mice, can neutralize "pore-forming toxins," which destroy cells by poking holes in their cell membranes. Unlike other anti-toxin platforms that need to be custom synthesized for individual toxin type, the nanosponges can absorb different pore-forming toxins regardless of their molecular structures...
14 Genetic Targets That May Provide Insight For The Treatment Of Cardiovascular Disease
Date: Apr-15-2013Through a collaborative genome-wide study on individuals, researchers have discovered 14 new genetic variations that are associated with heart rate. Since heart rate is a marker of cardiovascular health, these findings could provide a better understanding of genetic regulation of heart beat and is a first step towards identifying targets for new drugs to treat cardiovascular disease. The study, titled, "Identification of Heart Rate-Associated Loci and Their Effects on Cardiac Conduction and Rhythm Disorders," was published online this week in the April issue of Nature Genetics...
When Bacterial Security Agents Go Rogue
Date: Apr-15-2013CRISPR, a system of genes that bacteria use to defend themselves against viruses, has been found to be involved in helping some bacteria evade the mammalian immune system. The results were scheduled for publication April 14 in Nature. CRISPR is itself a sort of immune system for bacteria. Its function was discovered by dairy industry researchers seeking to prevent phages, the viruses that infect bacteria, from ruining the cultures used to make cheese and yogurt...
Advances In Understanding Of Genetic Defects Underlying Childhood Low-Grade Gliomas
Date: Apr-15-2013The St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project has identified mutations responsible for more than half of a subtype of childhood brain tumor that takes a high toll on patients. Researchers also found evidence the tumors are susceptible to drugs already in development. The study focused on a family of brain tumors known as low-grade gliomas (LGGs). These slow-growing cancers are found in about 700 children annually in the U.S., making them the most common childhood tumors of the brain and spinal cord...
Study Of CYPLEXINOL® Finds Significant Improvement In Pain, Stiffness And Quality Of Life In Patients With Osteoarthritis
Date: Apr-15-2013ZyCal Bioceuticals, Inc. have announced results of the first double-blind, placebo-controlled study evaluating the benefits of Cyplexinol® in alleviating symptoms of osteoarthritis. The results were published in the April/May 2013 issue of Integrative Medicine: A Clinician's Journal, (http://www.imjournal.com/open_cyp_ost) a peer-reviewed publication providing practitioners with a practical and comprehensive approach to integrating alternative therapies with conventional medicine...
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