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Side Effect Of Retinal Detachment May Be Prevented By Ranibizumab
Date: Apr-11-2013Proliferative vitreoretinopathy (PVR), or the formation of scar tissue in the eye, is a serious, sight-threatening complication in people recovering from surgical repair of retinal detachment. PVR is difficult to predict, lacks effective treatment options, and substantially reduces an individual's quality of life. Each year 55,000 people are at risk for developing PVR in the United States alone...
Combination Of 2 Existing Drugs Appears Safe In Patients Who Have Not Responded To Previous Treatments For Resistant Lung Cancer
Date: Apr-11-2013A new chemotherapy regimen appears to produce minimal side effects in patients with lung cancer that has not responded to previous therapy, paving the way for additional research to determine if the new regimen also helps shrink tumors, according findings to be presented by Fox Chase Cancer Center researchers at the AACR Annual Meeting 2013. "I'm very optimistic that we will show this protocol helps lung cancer patients who have run out of other options," says study author Hossein Borghaei, MS, DO, director of Thoracic Medical Oncology at Fox Chase...
Hereditary Neuropathy And Chemotherapy-Induced Peripheral Neuropathy May Share Genetic Roots In Some Patients
Date: Apr-11-2013Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy, a Mayo Clinic study has found. The study identified gene variations that can predispose people to chemotherapy-induced peripheral neuropathy, a condition that is hard to predict and often debilitating enough to cause cancer patients to stop their treatment early. Results of the research were presented at the American Association for Cancer Research Annual Meeting 2013 in Washington, D.C...
A Promising Drug Can Help Prevent Head And Neck Cancers
Date: Apr-11-2013Head and neck cancers typically begin in squamous cells that line moist surfaces inside the mouth, nose and throat. Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States, and it is sometimes preceded by the appearance of changes inside the oral cavity called precancerous lesions. The most common type of change is a white patch known as a leukoplakia. Because it often takes decades for leukoplakias to develop into HNSCC, there is a window of opportunity to recognize and revert precancerous changes, thus preventing this type of cancer...
ALS Drug Effects Highlight Potassium Channel Role In Spinal Muscular Atrophy
Date: Apr-11-2013There is no specific drug to treat spinal muscular atrophy (SMA), a family of motor neuron diseases that in its most severe form is the leading genetic cause of infant death in the United States and affects one in 6,000 people overall. But a new multispecies study involving a drug that treats amyotrophic lateral sclerosis (ALS) has pinpointed a mechanism of SMA that drug developers might be able to exploit for a new therapy...
Hepatitis Research Aided By New Rodent Viruses
Date: Apr-11-2013Newly discovered mouse viruses could pave the way for future progress in hepatitis research, enabling scientists to study human disease and vaccines in the ultimate lab animal. In a study to be published in mBio®, the online open-access journal of the American Society for Microbiology, scientists describe their search for viruses related to the human hepatitis C virus (HCV) and human pegiviruses (HPgV) in frozen stocks of wild mice...
Synthetic Materials Inspired By Bean Leaves May Be A Future Trap For Bedbugs
Date: Apr-11-2013Inspired by a traditional Balkan bedbug remedy, researchers have documented how microscopic hairs on kidney bean leaves effectively stab and trap the biting insects, according to findings published online in the Journal of the Royal Society Interface. Scientists at UC Irvine and the University of Kentucky are now developing materials that mimic the geometry of the leaves. Bedbugs have made a dramatic comeback in the U.S. in recent years, infesting everything from homes and hotels to schools, movie theaters and hospitals...
Genes Related To The Regulation Of The Cell Cycle Are Associated With Poor Patient Outcomes In Lung And Bladder Cancers
Date: Apr-11-2013Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes. Results presented at the AACR Annual Meeting 2013 show that in lung and bladder cancers, genes related to the regulation of the cell cycle are associated with poor patient outcomes. "We ultimately envision this as a prognostic tool to predict survival rates for people with tobacco related cancers...
'Old Sober' Helps With Hangovers
Date: Apr-11-2013One of the Crescent City's time-honored traditions - a steaming bowl of Yak-a-mein Soup, a.k.a., "Old Sober" - after a night of partying in the French Quarter actually does have a basis in scientific fact. That was the word from an overview of the chemistry of hangovers, presented as part of the 245th National Meeting & Exposition of the American Chemical Society, the world's largest scientific society. Alyson E. Mitchell, Ph.D...
Critical Metabolic Alterations Identified In Triple-Negative Breast Cancer Cells
Date: Apr-11-2013Researchers at Fox Chase Cancer Center have identified a host of small molecules critical to metabolism in cells of triple-negative breast cancer - one of the least understood groups of breast cancer. These molecules, called metabolites, include key players in energy regulation and lipid synthesis. They could help pave the way for helping researchers differentiate among different forms of the disease and ultimately point to new targets for treatment...
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