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EU Minimum Tax Legislation For Cigarettes Has Had No Effect On Smoking Prevalence, According To New Spanish Study
Date: Apr-06-2013Up to 2009 there is no statistically significant evidence of any reduction in smoking amongst men -- and very little evidence of a reduction in smoking amongst women -- resulting from the introduction of EU minimum tax legislation in Spain in 2006. This is despite the price of cigarettes rising up to three times faster than before the legislation came into effect, according to a new study published online in the journal Nicotine and Tobacco Research...
Abnormal Copy Numbers Characterises Prostate Cancer
Date: Apr-06-2013Non-invasive 'liquid biopsies' can find metastatic or recurrent prostate cancer, in a low cost assay suitable for most healthcare systems, finds research published in BioMed Central's open access journal Genome Medicine. Genomic signatures of prostate cancer, isolated from plasma DNA, display abnormal copy numbers of specific areas of chromosomes. It is even possible to separate out patients who develop resistance against hormone deprivation therapy, which is the most common form of treatment in men with metastatic prostate cancer. Prostate cancer is the most common cancer in men with 2...
Researchers Identify A Protein Responsible For The Correct Arrangement Of The Chromosome Centromeres In The Nucleus
Date: Apr-06-2013Two metres of DNA are packed into the cell nucleus, presumably based on a strictly defined arrangement. Researchers working with biologist Patrick Heun from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have now succeeded in explaining a phenomenon, which was first observed 40 years ago. The centromeres, namely the structures at the primary constriction of the X-shaped chromosomes, are clustered in a few specific locations in the cell nucleus. Using fruit flies as a model, the researchers have shown that a single protein plays a key role in this process...
EU Minimum Tax Legislation For Cigarettes Has Had No Effect On Smoking Prevalence
Date: Apr-06-2013Up to 2009 there is no statistically significant evidence of any reduction in smoking amongst men - and very little evidence of a reduction in smoking amongst women - resulting from the introduction of EU minimum tax legislation in Spain in 2006. This is despite the price of cigarettes rising up to three times faster than before the legislation came into effect, according to a new study published online in the journal Nicotine and Tobacco Research...
IDH1 And IDH2 Mutant Inhibitors Reverse Differentiation Blocks In Patient-Derived Tumor Samples
Date: Apr-06-2013Agios Pharmaceuticals, Inc., the leading biopharmaceutical company focused on discovering and developing novel drugs in the fields of cancer metabolism and rare metabolic genetic diseases, has announced the publication of two articles in the journal Science by Agios scientists and their collaborators demonstrating the effects of the company's small molecule isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) mutant specific inhibitors in primary human tumor models...
Brain Activity Mapping Project Aims To Understand The Brain
Date: Apr-06-2013The scientific tools are not yet available to build a comprehensive map of the activity in the most complicated 3 pounds of material in the world -- the human brain, scientists say in a newly published article. It describes the technologies that could be applied and developed for the Brain Activity Mapping (BAM) Project, which aims to do for the brain what the Human Genome Project did for genetics...
Verifying That Sorghum Is A New Safe Grain For People With Celiac Disease
Date: Apr-06-2013Strong new biochemical evidence exists showing that the cereal grain sorghum is a safe food for people with celiac disease, who must avoid wheat and certain other grains, scientists are reporting. Their study, which includes molecular evidence that sorghum lacks the proteins toxic to people with celiac disease, appears in ACS' Journal of Agricultural and Food Chemistry...
Genotype-Specific Targeted Therapies For Lung Cancer
Date: Apr-06-2013Physician-researchers at UT Southwestern Medical Center have identified a vulnerability of certain lung-cancer cells - a specific genetic weakness that can be exploited for new therapies. Although researchers have long known that mutant versions of the KRAS gene drive tumor formation and are key to cell survival in non-small cell lung cancer, the blocking of activated KRAS has proven difficult. For years, investigations have explored stopping lung cancer at this junction, which also would have an impact on many other cancers...
Smoking And Depressive Symptoms In Adolescent Girls Are "Red Flag" For Postmenopausal Osteoporosis
Date: Apr-06-2013First-Time Study Shows Smoking and Depression in Adolescents have Negative Impact on Bone Mineral Density, say Investigators in the Journal of Adolescent Health Depression, anxiety, and smoking are associated with lower bone mineral density (BMD) in adults, but these factors have not previously been studied during adolescence, when more than 50% of bone accrual occurs...
Roche Agree To Release All Trial Data On Tamiflu Drug
Date: Apr-06-2013The BMJ can reveal that following over three years of talks with pharmaceutical giant Roche, the Cochrane Collaboration is at last being granted access to "all 74 Roche-sponsored trials" of the influenza drug, Tamiflu (oseltamivir). In an email to the Cochrane researchers on 2 April, Roche said they would provide "each CSR [clinical study report]" over the next few months. The reports will be edited by Roche "to ensure patient confidentiality and to protect legitimate commercial interests"...
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