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Computer Modeling May Resolve Conflicting Results And Offer Hints For New Drug-Design Strategies For Parkinson's Disease
Date: Apr-03-2013Clumps of proteins that accumulate in brain cells are a hallmark of neurological diseases such as dementia, Parkinson's disease and Alzheimer's disease. Over the past several years, there has been much controversy over the structure of one of those proteins, known as alpha synuclein. MIT computational scientists have now modeled the structure of that protein, most commonly associated with Parkinson's, and found that it can take on either of two proposed states - floppy or rigid...
Risk For Coronary Heart Disease Increases With BMI
Date: Apr-03-2013Coronary heart disease (CHD) increases with BMI, as well as with age, finds an article published in BioMed Central's open access journal BMC Medicine. The research from the Million Women Study indicates that increased weight increases risk of CHD equivalent to that caused by getting older. Researchers from the University of Oxford followed the health of 1.2 million women from England and Scotland for (on average) almost a decade...
Supplementation Of Alternative Fuels Could Protect The Brain During Hypoglycemia
Date: Apr-03-2013Tight control of blood glucose levels is critical to mitigating the long-term complications of diabetes; however, the intensive insulin therapy required for this control is frequently accompanied by recurrent episodes of low blood sugar (hypoglycemia). Hypoglycemic episodes have been implicated in brain damage and cognitive impairment. Though the brain depends predominantly on glucose as an energy source, it can also use alternative fuels, such as lactate, to satisfy its energy requirements...
ALS/FTD Neurodegeneration May Be Caused By 'RNA Sponge' Mechanism
Date: Apr-03-2013The most common genetic cause of both ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) was recently identified as an alteration in the gene C9orf72. But how the mutation causes neurodegenerative disease appeared mysterious. Researchers at Emory University School of Medicine have demonstrated that this ALS/FTD mutation may be harmful because it creates an "RNA sponge," soaking up an important regulatory protein that binds RNA. The results were published online in the Proceedings of the National Academy of Sciences, Early Edition...
Rewarding Healthy Behaviors In The Workplace
Date: Apr-03-2013Do cash rewards for healthier habits work? Maybe, says a new study, if you add on one more condition - peer pressure. A growing number of companies are offering employees an opportunity to boost earning power at work via cash incentives to stay healthy. Under the Affordable Care Act, employers will soon be able to offer even larger financial incentives to prod healthy lifestyle behaviors among their workforce, such as quitting smoking and losing weight...
Visiting Your Doctor Following ER Care For Chest Pain Reduces Risk Of Heart Attack, Death
Date: Apr-03-2013Seeing a doctor within a month of an emergency room visit for chest pain significantly reduced the risk of heart attack or death among high risk patients, according to research published the American Heart Association journal Circulation. Chest pain is the most common reason people go to the emergency room in developed countries and accounts for more than 5 million ER visits each year in the United States. The study is the first to demonstrate the importance of follow-up care for chest pain patients after leaving the ER, researchers said...
Study Examines The Role Adverse Reactions Play In Statin Discontinuation
Date: Apr-03-2013Despite their well-documented benefits, statins, drugs used to lower cholesterol, are commonly discontinued in routine care. Statin discontinuation has been linked to increased risk for cardiovascular events and death in patients with coronary artery disease; nevertheless, the reasons for discontinuation are only starting to be explored...
Susceptibility To Some Viral Infections May Be Increased By Newly Approved Blood Thinner
Date: Apr-03-2013A study led by researchers at the University of North Carolina indicates that a newly approved blood thinner that blocks a key component of the human blood clotting system may increase the risk and severity of certain viral infections, including flu and myocarditis, a viral infection of the heart and a significant cause of sudden death in children and young adults. For the past 50 years, people with the heartbeat irregularity, atrial fibrillation, and others at increased risk for forming potentially life-threatening blood clots have been given the anticoagulant drug warfarin...
Therapeutic Target For Prostate Cancer Provided By Newly Identified Tumor Suppressor
Date: Apr-03-2013Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have identified how an enzyme called PKCζ suppresses prostate tumor formation. The finding, which also describes a molecular chain of events that controls cell growth and metastasis, could lead to novel ways to control disease progression. Working in close collaboration, the labs of Maria T. Diaz-Meco, Ph.D., and Jorge Moscat, Ph.D., found that PKCζ controls the activation of a pro-tumor gene called c-Myc. Normally, PKCζ's alteration keeps c-Myc in check...
Delay Between Prostate Cancer Diagnosis And Treatment Longer For African Americans
Date: Apr-03-2013African American men on average wait a week longer than their Caucasian counterparts between the initial diagnosis of prostate cancer and treatment, according to University of North Carolina researchers. The study was published online in Cancer, the journal of the American Cancer Society, by a team led by Ronald Chen, MD, MPH, assistant professor with the UNC Lineberger Comprehensive Cancer Center. The study is the first published population-based examination of racial disparities in prostate cancer treatment delay. Using data from Medicare patients, Dr...
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