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Cisplatin-Resistant Cancer Cells Sensitive To Experimental Anticancer Drugs Called PARP Inhibitors
Date: Apr-03-2013Cisplatin-resistant non-small cell lung cancer cells expressed high levels of hyperactivated PARP1. Cells succumbed to PARP inhibitors in vitro. PARP inhibitor slowed cisplatin-resistant tumor growth in mice. Poly (ADP-ribose) polymerase inhibitors may be a novel treatment strategy for patients with cancer that has become resistant to the commonly used chemotherapy drug cisplatin, according to data from a preclinical study published in Cancer Research, a journal of the American Association for Cancer Research...
Sildenafil Helps Turn 'Bad' White Adipose Tissue Into 'Good And Healthy' Brown Adipose Tissue
Date: Apr-03-2013Although sildenafil is best known for promoting erections, it may also serve as a weight loss aid by coaxing our bodies to store more healthy "brown fat" relative to unhealthy "white fat" than it would otherwise do on its own. According to new research published online in The FASEB Journal, this is because sildenafil inhibits the breakdown of cyclic GMP, which has been well known as a messenger molecule used by the body to control blood pressure and flow, and has now been shown to play an important role determining which type of fat - white or brown - the body stores...
Money For Weight Loss Works
Date: Apr-02-2013More and more companies are now offering novel weight loss incentive schemes in an effort to encourage healthier habits in the workplace. A new study, carried out by researchers at the Universiy of Michigan, found that cash rewards are an effective form of weight loss incentive. With the Affordable Care Act, more employers will be able to offer large cash incentives to encourage healthy behaviors, such as losing weight or quitting smoking for their employees...
Unusual Bird Flu Cases Baffle Experts, China
Date: Apr-02-2013New cases of an unusual bird flu virus strain infection that is affecting humans is baffling experts. Chinese health authorities stepped up monitoring after four more confirmed cases of H7N9 bird flu were reported today, bringing the total so far to seven. The four new human infections have been reported in the Jiangsu Province, eastern China. In Shanghai, where two people died of H7N9 avian influenza earlier this month, the municipal government announced in a press briefing that statistics on unexplainable pneumonia cases will be reported on a daily basis...
Heart Risks May Also Predict Dementia Risk
Date: Apr-02-2013Evaluating a person's future risk of heart disease and stroke may be a better predictor of mental decline than a dementia risk test. The finding came from new research published in the journal Neurology, the medical journal of the American Academy of Neurology. "This is the first study that compares these risk scores with a dementia risk score to study decline in cognitive abilities 10 years later," said Sara Kaffashian, PhD, with the French National Institute of Health and Medical Research (INSERM) in Paris, France...
People Who Eat Fish Live Longer
Date: Apr-02-2013Eating fish high in omega-3 fatty acids, as a regular part of your diet, can actually add years to your life, according to a new study published in the journal Annals of Internal Medicine. Results of the study showed that elderly adults who have greater blood levels of omega-3 fatty acids - found almost uniquely in seafood and fatty fish - could decrease their total mortality risk by nearly 27% and their mortality risk from heart disease by 35%...
California's Physician Groups Support MOU Advancing Coordinated Care Demonstration Project For State's Medi-Cal/Medicare Patients
Date: Apr-02-2013California's physician groups gave their encouragement and support last week for the memorandum of understanding between the federal Medicare-Medicaid Coordination Office and California's Health and Human Services Agency to move ahead with a three-year, eight-county demonstration project for seniors and people with disabilities who are eligible for both Medi-Cal and Medicare...
Tonsillectomy In Adults With Severe Recurrent Sore Throats May Benefit Some People
Date: Apr-02-2013Tonsillectomy may result in fewer severe sore throats and could benefit some adult patients, according to a randomized trial published in CMAJ (Canadian Medical Association Journal). Recurrent severe sore throats result in lost work or school days and frequent use of antibiotics. Researchers from Finland conducted a randomized open trial to determine whether tonsillectomy reduced episodes of severe sore throats (pharyngitis). The trial involved 86 patients, 46 of whom had the procedure and 40 who did not...
Mutated Histone Directly Links A Protein To A Rare Brain Stem Cancer In Children
Date: Apr-02-2013Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. New research from C. David Allis' laboratory at Rockefeller University may bring scientists closer to designing cancer therapeutics that can target tumors with pinpoint accuracy...
Helping Physicians Determine When EEG Should Be Ordered In Hospitals
Date: Apr-02-2013A retrospective study of patients who had in-hospital electroencephalography (EEG) has established that EEG is a valuable tool that could be deployed more widely to identify treatable causes of impaired consciousness in the hospital setting. The study is published in the April issue of the Mayo Clinic Proceedings. Altered mental status (AMS) and paroxysmal spells of uncertain origin are common among hospitalized patients...
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