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Military Personnel Who Undergo Newer SLAP Tear Surgery More Likely To Return To Active Duty
Date: Mar-26-2013Research presented at the American Orthopaedic Society for Sports Medicine's Specialty Day in Chicago, IL shows that biceps tenodesis surgery is safe and effective for individuals who suffer a SLAP (superior labral anterior posterior) tear of the shoulder. Patients examined had previously undergone unsuccessful arthroscopic repair for their injuries. "Our research focused on a sample of 42 active-duty men and women who were unable to return to duty after primary arthroscopic SLAP repair," said Frank McCormick, MD, and CDR Matthew T...
Experts Examine Profiles From Patients With Early Stage Lung Adenocarcinoma, Identify Patterns Of Mutations To Help Inform Design Of Future Trials
Date: Mar-26-2013Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non-small cell lung cancer (NSCLC), surgical resection remains the treatment of choice with adjuvant chemotherapy. In a recent study published in the April 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, researchers identified patterns of mutations in early stage node negative lung adenocarcinoma...
Childhood Physical Activity Likely Reduces Fracture Risk In Old Age
Date: Mar-26-2013Get out there and regularly kick that soccer ball around with your kids, you may be helping them prevent a broken hip when they are older, say researchers presenting their work at the American Orthopaedic Society for Sports Medicine's Specialty Day in Chicago, IL. "According to our study, exercise interventions in childhood may be associated with lower fracture risks as people age, due to the increases in peak bone mass that occurs in growing children who perform regular physical activity," said lead author, Bjorn Rosengren, MD, PhD of Skane University Hospital, Malmo, Sweden...
DNA Damage Found To Occur As Part Of Normal Brain Activity
Date: Mar-26-2013Scientists at the Gladstone Institutes have discovered that a certain type of DNA damage long thought to be particularly detrimental to brain cells can actually be part of a regular, non-harmful process. The team further found that disruptions to this process occur in mouse models of Alzheimer's disease - and identified two therapeutic strategies that reduce these disruptions. Scientists have long known that DNA damage occurs in every cell, accumulating as we age...
The Molecular Roots Of Down Syndrome Unraveled
Date: Mar-26-2013What is it about the extra chromosome inherited in Down syndrome - chromosome 21 - that alters brain and body development? Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have new evidence that points to a protein called sorting nexin 27, or SNX27. SNX27 production is inhibited by a molecule encoded on chromosome 21. The study, published in Nature Medicine, shows that SNX27 is reduced in human Down syndrome brains. The extra copy of chromosome 21 means a person with Down syndrome produces less SNX27 protein, which in turn disrupts brain function...
For Rapidly Increasing Form Of Esophageal Cancer, Molecular 'Signature' Found
Date: Mar-26-2013During the past 30 years, the number of patients with cancers that originate near the junction of the esophagus and stomach has increased approximately 600 percent in the United States. The first extensive probe of the DNA of these esophageal adenocarcinomas (EACs) has revealed that many share a distinctive mix-up of letters of the genetic code, and found more than 20 mutated genes that had not previously been linked to the disease...
Infants With Necrotizing Enterocolitis Treated With Amniotic Fluid Stem Cells
Date: Mar-26-2013Stem cells taken from amniotic fluid were used to restore gut structure and function following intestinal damage in rodents, in new research published in the journal Gut. The findings pave the way for a new form of cell therapy to reverse serious damage from inflammation in the intestines of babies. The study, funded by Great Ormond Street Hospital Children's Charity, investigated a new way to treat necrotizing enterocolitis (NEC), where severe inflammation destroys tissues in the gut...
Decision-Making In Older People Improved By Parkinsons' Drug
Date: Mar-26-2013A drug widely used to treat Parkinson's Disease can help to reverse age-related impairments in decision making in some older people, a study from researchers at the Wellcome Trust Centre for Neuroimaging has shown. The study, published in the journal Nature Neuroscience, also describes changes in the patterns of brain activity of adults in their seventies that help to explain why they are worse at making decisions than younger people. Poorer decision-making is a natural part of the ageing process that stems from a decline in our brains' ability to learn from our experiences...
Protein With Key Job In Muscle Function Moonlights In Nucleus To Help Regulate Genes
Date: Mar-26-2013A key building block of life, actin is one of the most abundant and highly conserved proteins in eukaryotic cells. First discovered in muscle cells more than 70 years ago, actin has a well-established identity as a cytoplasmic protein that works by linking itself in chains to form filaments. Fibers formed by these actin polymers are crucial to muscle contraction. So it came as a surprise when scientists discovered actin in the nucleus. Labs have been working for the past few decades to figure out exactly what it's doing there...
Teenage Pregnancy A Greater Risk For Sexually Abused Or Neglected Adolescent Girls
Date: Mar-26-2013Abused or neglected teenage girls become teen mothers at nearly five times the national rate of teen motherhood. A new Cincinnati Children's Hospital Medical Center study, published in the eFirst pages of the journal Pediatrics, shows that teen childbirth rates are more than 20 percent for abused and neglected teens. This compares to the national teen childbirth rate of approximately 4 percent. The finding holds true even after taking into account such factors as race, family income and whether the family was a one- or two-parent household...
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