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Potential Treatments For Ebola And Other Deadly Viruses
Date: Mar-25-2013Illnesses caused by many of the world's most deadly viruses cannot be effectively treated with existing drugs or vaccines. A study published by Cell Press in the journal Chemistry & Biology has revealed several compounds that can inhibit multiple viruses, such as highly lethal Ebola virus, as well as pathogens responsible for rabies, mumps, and measles, opening up new therapeutic avenues for combating highly pathogenic viruses...
Brain's Visual Cortex Activated By Reward Linked To Image
Date: Mar-25-2013Once rhesus monkeys learn to associate a picture with a reward, the reward by itself becomes enough to alter the activity in the monkeys' visual cortex. This finding was made by neurophysiologists Wim Vanduffel and John Arsenault (KU Leuven and Harvard Medical School) and American colleagues using functional brain scans and was published recently in the leading journal Neuron. Our visual perception is not determined solely by retinal activity. Other factors also influence the processing of visual signals in the brain. "Selective attention is one such factor," says Professor Wim Vanduffel...
Special Issue Of Translational Research Is Devoted To The Topic Of The Gene Therapy
Date: Mar-25-2013The April issue of Translational Research examines the progress and outlook of gene therapy research, with a specific focus on the clinical applicability of gene therapy today. Research articles included in the special issue highlight current studies that, after decades of trial and error, may provide evidence for a clear path of treatment and cure for many diseases. There are more than 1,800 genetic disorders known in humans, and only a small fraction of these can be treated and even fewer cured. Some of these disorders are exceedingly rare, others more common...
Risk Factors In Prostate Cancer: Genetics, Age And Ethnicity
Date: Mar-25-2013"Are there genetic risk factors for PCa? Yes, and BRCA2 and HOXB13 are useful for predicting high-risk disease," said Jack Cuzick (GB) president of the International Society for Cancer Prevention (ISCaP), referring to the two genes implicated in high-risk prostate disease. Cuzick gave a report on the Consensus Statement for Prostate Cancer Prevention at the closing plenary session of the 28 Annual EAU Congress. "The goal should be to integrate with other protein markers in order to develop risk-adapted screening algorithms," he explained...
Tests Of Resistance To Hormone Could Help Doctors Monitor And Treat Kidney Disease Patients
Date: Mar-25-2013The kidneys' response to a particular hormone may affect kidney disease patients' heart health and longevity, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings may help doctors as they monitor and treat patients with kidney disease. In patients with chronic kidney disease (CKD), blood levels of a hormone called fibroblast growth factor-23 (FGF-23) rise in parallel with declining kidney function, causing excess excretion of phosphorus in the urine...
Blocking An Inflammation Pathway Prevents Cardiac Fibrosis, Could Lead To New Therapeutic Strategy For Heart Failure
Date: Mar-24-2013New research from UC Davis published in the Proceedings of the National Academy of Sciences Led by Nipavan Chiamvimonvat, cardiologist and professor of internal medicine, a team of researchers tested a compound that inhibits the enzyme soluble epoxide hydrolase -- or sEH -- one of the key players in the robust immune-system response that heals tissue following an injury. The enzyme, however, can become counterproductive after a cardiac event. Chiamvimonvat explained that sEH increases proinflammatory lipid mediators, leading to long-term, heightened inflammatory conditions...
Titan's Implant For Treating Opioid Dependence - FDA Panel Gives A Cautious 'Yes'
Date: Mar-24-2013Probuphine, a buprenorphine subdermal implant formulation for adults with opioid dependence has been given a green light by an FDA Advisory Committee (Panel). The Panel cited a favorable benefit-risk profile and an unmet need. According to Titan Pharmaceuticals Inc., the FDA Panel voted 10 to 4 in favor, with one abstention. The Panel, which consists of 15 experts, advises the FDA on whether it should approve or turn down New Drug Applications (NDAs). The Agency does not have to follow its recommendations, but nearly always does...
Next Generation Condoms - Bill Gates Foundation Awarding $100k Grants
Date: Mar-24-2013If you think you can create a Next Generation Condom that considerably enhances or preserves pleasure, the Melinda and Bill Gates Foundation might award you a Phase I $100,000 grant. The aim is to improve condom uptake and regular use. Male condoms are inexpensive, easy to produce and distribute, they are available all over the world, even in remote and resource poor settings. Currently, about 15 billion condoms are produced each year and there are an estimated 750 million users. According to Grand Challenges in Global Health, it is a steadily growing market...
Scientists Discover How The Brain Keeps Track Of Similar But Distinct Memories
Date: Mar-24-2013Ever find yourself racking your brain on a Monday morning to remember where you put your car keys? When you do find those keys, you can thank the hippocampus, a brain region responsible for storing and retrieving memories of different environments-such as that room where your keys were hiding in an unusual spot. Now, scientists at the Salk Institute for Biological Studies have helped explain how the brain keeps track of the incredibly rich and complex environments people navigate on a daily basis...
Men May Have Evolved With A Natural Aversion To Adultery With Friends' Wives
Date: Mar-24-2013After outgrowing teenage infatuations with the girl next door, adult males seem to be biologically designed to avoid amorous attractions to the wife next door, according to a University of Missouri study that found adult males' testosterone levels dropped when they were interacting with the marital partner of a close friend. Understanding the biological mechanisms that keep men from constantly competing for each others' wives may shed light on how people manage to cooperate on the levels of neighborhoods, cities and even globally...
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