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Flagellin May Be Key In Stimulating Body's Natural Defences Against Urinary Tract Infections
Date: Mar-18-2013A new study by British scientists reveals that motile Escherichia coli isolates demonstrated significant activation of NF-(Kappa)B signaling suggesting that flagellin plays a key role in up-regulating the host innate defences against urinary tract infections (UTIs). UTIs are commonly caused by Escherichia coli. The host innate defences function to protect the uro-epithelium from microbial assault via a variety of mechanisms. These include NF-κB signalling pathways activated via cell-surface Toll-like-receptors responding to bacterial pathogen associated molecular patterns (PAMPs)...
In Men With Localized PCa, Surgery Is Superior To Radiotherapy: Swedish Study
Date: Mar-18-2013Surgery offers better survival benefit for men with localised prostate cancer, according to a large observational study, conducted by a group of researchers in Sweden and the Netherlands. The study won the second prize for best abstract in oncology at the 28th Annual EAU Congress which opened in Milan 15 March. "The current gold standard management of localised prostate cancer is radical therapy, either as surgery or radiation therapy...
Technique To Predict Hotspots For Future Flu Outbreaks
Date: Mar-18-2013This year's unusually long and rocky flu season would be nothing compared to the pandemic that could occur if bird flu became highly contagious among humans, which is why UCLA researchers and their colleagues are creating new ways to predict where an outbreak could emerge...
Childhood Cancer And Survivor Fertility
Date: Mar-18-2013As success rates in treating childhood cancers have improved, greater emphasis is being placed on quality of life issues following successful treatment. Many cancer treatments can lead to infertility, but there are few methods to preserve the fertility of children who have not entered puberty. Spermatogonial stem cells (SSCs), which produce sperm cells, are present prior to the start of puberty...
Risk-Mitigating Behaviors For People With Peanut/Tree Nut Allergies To Minimize Risk Of Reactions On Airplane Flights
Date: Mar-18-2013Few situations can provoke more anxiety for people with peanut or tree-nut allergies than having an allergic reaction while flying on an airplane and being unable to get help. But in a new study, published in the Journal of Allergy and Clinical Immunology-In Practice, researchers found passengers who engaged in eight mitigating factors were less likely to report an allergic reaction. This is the first study to show that in-flight peanut and tree nut allergy is an international problem, says lead author and pediatrician Matthew Greenhawt, M.D., M.B.A., M.Sc...
Novel Therapeutic Strategy For Erectile Dysfunction
Date: Mar-18-2013Transplantation of mesenchymal stem cells cultivated on the surface of nanofibrous meshes could be a novel therapeutic strategy against post-prostatectomy erectile dysfunction (ED), conclude the authors of a study which is to be presented at the 28th Annual EAU Congress later this week. The study was conducted by a group of Korean scientists and will be awarded 3rd prize for best abstract in non-oncology research on the opening day of the congress...
New Cells Found In The Urethra Which May Detect Hazardous Substances
Date: Mar-18-2013A recent study conducted by a group of German scientists revealed the presence of a previously unknown cell in the urethra of mice. These chemosensory cholinergic brush cells are in close contact to sensory neurons that express cholinergic receptors. The authors suggest that in analogy to brush cells of the respiratory tract, the urethral brush cells may also serve as sentinels being able to detect hazardous substances and prevent their further retrograde ingression. The results of this investigation were presented at the upcoming 28th Annual EAU Congress in Milan...
In Castration Resistant Prostate Cancer, Study Shows Additional Role For Abiraterone In Blocking Tumor Growth
Date: Mar-18-2013As part of an EU-supported IMI-PREDECT consortium, a Dutch study showed that anti-androgenic properties of the drug abiraterone may provide an additional mechanism of action in blocking tumour growth of castration resistant prostate cancer (CRPC)...
Cytoskeletal Dysregulation Underlies Buruli Ulcer Formation
Date: Mar-18-2013Mycobacterium ulcerans infects the skin and subcutaneous tissues and secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers. In this issue of the Journal of Clinical Investigation, researchers led by Caroline Demangel at the Pasteur Institue in Paris investigated the molecular actions of mycolactone and found that it dysregulates the cellular skeleton (cytoskeleton) through activation of a protein known as N-WASP. They found that excessive N-WASP activity caused defects in cell adhesion and migration that impaired the integrity of the skin...
How Mindfulness Can Improve Self-Knowledge
Date: Mar-18-2013Mindfulness - paying attention to one's current experience in a non-judgmental way - might help us to learn more about our own personalities, according to a new article published in the March 2013 issue of Perspectives on Psychological Science, a journal of the Association for Psychological Science. Recent research has highlighted the fact that we have many blind spots when it comes to understanding our patterns of thinking, feeling, and behaving. Despite our intuition that we know ourselves the best, other people have a more accurate view of some traits (e.g., intellect) than we do...
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