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The Dramatic Differences Among People With Schizophrenia May Be Explained By A Single Gene

Date: Mar-06-2013
Some of the dramatic differences seen among patients with schizophrenia may be explained by a single gene that regulates a group of other schizophrenia risk genes. These findings appear in a new imaging-genetics study from the Centre for Addiction and Mental Health (CAMH). The study revealed that people with schizophrenia who had a particular version of the microRNA-137 gene (or MIR137), tended to develop the illness at a younger age and had distinct brain features - both associated with poorer outcomes - compared to patients who did not have this version. This work, led by Drs...

Revision Of Latest Methodologies For Studying Evolution And Interaction Of Proteins

Date: Mar-06-2013
Spanish National Cancer Research Centre (CNIO) researchers Alfonso Valencia, Director of the Structural Biology and Biocomputing Programme and David de Juan, jointly with Florencio Pazos, from the Spanish National Centre for Biotechnology (CNB-CSIC), publish a review on the latest computational methods that, based on evolutionary principles, are revolutionising the field of analysis and prediction of protein structure, function and protein-protein interactions, as well as the short- and long-term expectations for the field...

Study Confirms Rapid Effectiveness Of Temporary, Nonsurgical Alternative To LASIK

Date: Mar-06-2013
A contact lens technique called overnight orthokeratology (OK) brings rapid improvement in vision for nearsighted patients. Now a new study shows that OK treatment works mainly by flattening the front of the cornea, reports a recent study, "Posterior Corneal Shape Changes in Myopic Overnight Orthokeratology", appearing in the March issue of Optometry and Vision Science, official journal of the American Academy of Optometry. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health...

Activity-Based Restorative Therapy Programs May Provide Substantial Benefits For Persons With Chronic Spinal Cord Injury

Date: Mar-06-2013
A new study by Kennedy Krieger Institute's International Center for Spinal Cord Injury (Epub ahead of print) finds that long-term lower extremity functional electrical stimulation (FES) cycling, as part of a rehabilitation regimen, is associated with substantial improvements in individuals with chronic spinal cord injury (SCI). Improvements include neurological and functional gains, as well as enhanced physical health demonstrated by decreased fat, increased muscle mass and improved lipid profile...

Mirabegron Found To Be Effective And Well Tolerated In Patients With Overactive Bladder

Date: Mar-06-2013
In a new phase III trial mirabegron, a β3-adrenoceptor agonist, given once daily for 12 weeks, reduced the frequency of incontinence episodes and number of daily urinations, and improved urgency and nocturia in adults with overactive bladder (OAB) compared to those in a placebo group. The incidence of common adverse events (hypertension, urinary tract infection, headache, nasopharyngitis) was similar in the mirabegron and placebo groups in this study. Rates of dry mouth and constipation were similar in the drug and placebo groups. The study is published in the Journal of Urology®...

Reducing Effects Of Traumatic Events At The Molecular Level

Date: Mar-06-2013
Reducing fear and stress following a traumatic event could be as simple as providing a protein synthesis blocker to the brain, report a team of researchers from McLean Hospital, Harvard Medical School, McGill University, and Massachusetts General Hospital in a paper published in the Proceedings of the National Academy of Sciences...

Support Interventions May Decrease Stress Hormone Which Foreshadows Postpartum Depression In New Mothers

Date: Mar-06-2013
Women who receive strong social support from their families during pregnancy appear to be protected from sharp increases in a particular stress hormone, making them less likely to develop postpartum depression, according to a new study published in Clinical Psychological Science, a journal of the Association for Psychological Science...

Vitamin B12 Deficiency Prevalent Among Refugees

Date: Mar-06-2013
New research from the University of Adelaide has discovered a high prevalence of vitamin B12 deficiency among refugees, prompting calls for refugees to be routinely screened for the problem soon after they arrive. Vitamin B12 deficiency is a sign of severe malnourishment and can result in permanent damage to the nervous system. For women of child-bearing age, vitamin B12 deficiency can lead to developmental defects in their unborn children. If left untreated, the deficiency could be fatal...

Cognitive Behavioral Therapy Helps To Treat Diabetic Neuropathies

Date: Mar-06-2013
Researchers at Boston University School of Medicine (BUSM) and VA Boston Healthcare System (VA BHS) have found that cognitive behavioral therapy (CBT) can help relieve pain for people with painful diabetic neuropathies. The study, which is the first of its kind to examine this treatment for people with type II diabetes mellitus, is published in the March issue of the Journal of Pain. Type II diabetes mellitus is the most common form of the disease and affects more than 20 million Americans...

Enzyme's Double Life Revealed - Critical Role In Cancer Blood Supply

Date: Mar-06-2013
Studied for decades for their essential role in making proteins within cells, several amino acids known as tRNA synthetases were recently found to have an unexpected - and critical - additional role in cancer metastasis in a study conducted collaboratively in the labs of Karen Lounsbury, Ph.D., University of Vermont professor of pharmacology, and Christopher Francklyn, Ph.D., UVM professor of biochemistry...