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Fighting Cancer With Trackable Drug-Filled Nanoparticles
Date: Mar-04-2013Tiny particles filled with a drug could be a new tool for treating cancer in the future. A new study published by Swedish scientists in Particle & Particle Systems Characterization shows how such nanoparticles can be combined to secure the effective delivery of cancer drugs to tumour cells - and how they can be given properties to make them visible in MR scanners and thus rendered trackable...
Proposed Revision Of The Diagnostic Criteria For Wolfram Syndrome
Date: Mar-04-2013Researchers at IDIBELL and CIBERER Virginia Nunes and Miguel Lopez de Heredia have collected data from 400 patients with Wolfram syndrome published worldwide in the last fifteen years to better understand the natural history of disease. The findings lead them to propose a revision of the diagnostic criteria of the disease because 15% of paediatric patients escape from diagnosis. The results of this review have been published in the online edition of the journal Genetics in Medicine to coincide with the World Day of rare diseases, on February 28th...
Children With Learning Disabilities Develop Less Secure Attachments With Mothers And Teachers
Date: Mar-04-2013In addition to struggling in school, many learning disabled children are known to face social and emotional challenges including depression, anxiety, and isolation. Often beginning early in childhood, they become more pronounced during adolescence, an emotionally turbulent time. For these youngsters, more positive relationships with the significant adults in their lives - including parents and teachers - can improve learning and "socioemotional" experiences, says Dr. Michal Al-Yagon of Tel Aviv University's Jaime and Joan Constantiner School of Education...
Using Lipid Nanoparticles To Deliver Genes And Drugs
Date: Mar-04-2013At the Faculty of Pharmacy of the Basque Public University (UPV/EHU) the Pharmacokinetics, Nanotechnology and Gene Therapy research team is using nanotechnology to develop new formulations that can be applied to drugs and gene therapy.Specifically, they are using nanoparticles to design systems for delivering genes and drugs; this helps to get the genes and drugs to the point of action so that they can produce the desired effect. The research team has shown that lipid nanoparticles, which they have been working on for several years, are ideal for acting as vectors in gene therapy...
Epidemiological Study Finds Physical Activity Does Not Protect Against In Situ Breast Cancer
Date: Mar-04-2013A European study published in the Cancer Epidemiology, Biomarkers & Prevention journal has analysed the association between physical activities and in situ or non-invasive breast cancer, or, in other words, cancer that has not yet invaded cells within or outside of the breast. Headed by researchers from ten European countries including Spain, the work carried out under the framework of the European Prospective Investigation into Cancer and Nutrition (EPIC) concludes that physical activity has no relation with the risk of developing this type of non-invasive cancer...
H5N1 Infection Of Mammals Enabled By Mutation Altering Stability Of Surface Molecule In Acid
Date: Mar-04-2013A single mutation in the H5N1 avian influenza virus that affects the pH at which the hemagglutinin surface protein is activated simultaneously reduces its capacity to infect ducks and enhances its capacity to grow in mice according to research published ahead of print in the Journal of Virology. "Knowing the factors and markers that govern the efficient growth of a virus in one host species, tissue, or cell culture versus another is of fundamental importance in viral infectious disease," says Charles J. Russell of St. Jude Children's Research Hospital, Memphis, TN, an author on the study...
Multitasking While Driving May Compromise Vision And Alertness, Especially At Busy Intersections
Date: Mar-04-2013Most serious traffic accidents occur when drivers are making a left-hand turn at a busy intersection. When those drivers are also talking on a hands-free cell phone, "that could be the most dangerous thing they ever do on the road," said Dr. Tom Schweizer, a researcher at St. Michael's Hospital. Researchers led by Dr. Schweizer tested healthy young drivers operating a novel driving simulator equipped with a steering wheel, brake pedal and accelerator inside a high-powered functional MRI...
Brain Pathway Identified That Triggers Impulsive Eating
Date: Mar-04-2013New research from the University of Georgia has identified the neural pathways in an insect brain tied to eating for pleasure, a discovery that sheds light on mirror impulsive eating pathways in the human brain. "We know when insects are hungry, they eat more, become aggressive and are willing to do more work to get the food," said Ping Shen, a UGA associate professor of cellular biology in the Franklin College of Arts and Sciences...
Molecular Recycling Explains Cell Movement, May Lead To Improved Wound Healing
Date: Mar-04-2013Scientists at The University of Manchester have identified the method by which cells control the recycling of molecules, a process that is essential for them to move. The discovery provides researchers with a better understanding of how our bodies heal wounds. Working under Professor Martin Humphries, the Dean of the Faculty of Life Sciences, Dr Mark Morgan and his team at the Wellcome Trust Centre for Cell Matrix Research studied the role of integrins. These molecules are able to grab hold of the fibres surrounding the cell, like hands, allowing the cell to drag its self along...
Novel Discovery Resolves A 17-Year Scientific Debate About The Impact Of Mechanical Stretching On The Structure Of DNA
Date: Mar-04-2013A team of researchers led by Associate Professor Yan Jie from the Department of Physics at the National University of Singapore (NUS) Faculty of Science has identified three new distinct overstretched deoxyribonucleic acid (DNA) structures caused by mechanical stretching. This discovery provides a clear answer to a long-running debate among scientists over the nature of DNA overstretching. Debate on Possible DNA Structural Transitions Recent single-molecule studies revealed that mechanical stretching could induce transitions to elongated DNA structures...
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