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In Pediatric Kidney Transplant Recipients, Antibody Response Linked With Rejection

Date: Mar-03-2013
A transplanted kidney has a finite life expectancy because it often becomes the target of the recipient's immune system, which may mount antibodies that attack the organ. Because there is a critical need to extend the life of transplanted organs - especially in children, who can face two to three kidney transplants in their lifetime - researchers recently examined the role of this antibody-mediated injury in rejection and the effectiveness of medications to prevent it. Their findings are reported in the Journal of the American Society of Nephrology (JASN)...

Survival Improved For Metastatic Gastric Cancer Patients Who Undergo Surgery And Radiation

Date: Mar-02-2013
Researchers at Moffitt Cancer Center studied patients with metastatic gastric cancer and found that those who have both surgery and radiation have better survival than those who receive one or no form of treatment.  The study appeared in an online issue of Cancer. "There were an estimated 21,000 new cases of gastric cancer in the United States in 2010 and 11,000 deaths from the disease," said Ravi Shridhar, M.D., Ph.D., of the Radiation Oncology Department at Moffitt. "Most gastric cancers are diagnosed at advanced stages, when surgery may not be an option...

Breast Reconstruction Study Provides Data On 'Patient-Reported Outcomes' For Different Types Of Silicone Implants

Date: Mar-02-2013
For women undergoing breast reconstruction using implants, most patient-reported outcomes are similar with two different shapes of silicone gel-filled implants, reports a study in the March issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). Assessment of key areas of quality of life after breast reconstruction shows few significant differences with conventional round implants versus newer "shaped" implants, according to the new research, led by Dr. Sheina A. Macadam of University of British Columbia, Vancouver...

Two Antagonistic Proteins Help Keep Leukemia At Bay, Suggesting New Potential Treatments

Date: Mar-02-2013
Two proteins that scientists once thought carried out the same functions are actually antagonists of each other, and keeping them in balance is key to preventing diseases such as cancer, according to new findings published in the journal Developmental Cell by scientists at Fox Chase Cancer Center. The results suggest that new compounds could fight cancer by targeting the pathways responsible for maintaining the proper balance between the proteins...

Demand Exists For Comfortable, Visually Appealing Maternity Wear For Women Earlier In Pregnancies

Date: Mar-02-2013
Fashion retailers have seen an increase in demand for maternity wear in recent years, as sales for maternity clothing have increased while overall women's apparel sales have declined. Currently, most retailers produce maternity wear using a standardized size chart that begins with women in their seventh month of pregnancy. Retailers produce garments for women who are earlier in their terms by adjusting the sizes smaller proportionally based on the standardized chart...

Making Anti-Cancer Drug Particles Rod-Shaped Significantly Increases Their Ability To Target And Inhibit Breast Cancer Cells

Date: Mar-02-2013
Bioengineering researchers at University of California, Santa Barbara have found that changing the shape of chemotherapy drug nanoparticles from spherical to rod-shaped made them up to 10,000 times more effective at specifically targeting and delivering anti-cancer drugs to breast cancer cells. Their findings could have a game-changing impact on the effectiveness of anti-cancer therapies and reducing the side effects of chemotherapy, according to the researchers. Results of their study were published recently in Proceedings of the National Academy of Sciences...

Researchers Produce First Step-By-Step Look At Transcription Initiation

Date: Mar-02-2013
Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have achieved a major advance in understanding how genetic information is transcribed from DNA to RNA by providing the first step-by-step look at the biomolecular machinery that reads the human genome. "We've provided a series of snapshots that shows how the genome is read one gene at a time," says biophysicist Eva Nogales who led this research...

Seasonal Preference Discovered In Strains Of MRSA; Children At Higher Risk In Summer, Seniors In Winter

Date: Mar-02-2013
Strains of potentially deadly, antibiotic-resistant Staphylococcus aureus bacteria show seasonal infection preferences, putting children at greater risk in summer and seniors at greater risk in winter, according to results of a new nationwide study led by a Johns Hopkins researcher. It's unclear why these seasonal and age preferences for infection with methicillin-resistant Staph aureus (MRSA) occur, says Eili Klein, Ph.D., lead author on the study and a researcher at the Johns Hopkins Center for Advanced Modeling in the Social, Behavioral and Health Sciences...

Artificial Liver Could Be Powered By Swine Cells

Date: Mar-02-2013
Chronic or acute, liver failure can be deadly. Toxins take over, the skin turns yellow and higher brain function slows. "There is no effective therapy at the moment to deal with the toxins that build up in your body," said Neil Talbot, a Research Animal Scientist for the USDA Agricultural Research Service. "Their only option now is to transplant a liver." Talbot thinks a line of special liver cells could change that...

First European Laboratory Obtains Accreditation For New Tissue-Typing Method For Stem Cell Transplants

Date: Mar-02-2013
Tests based on next-generation sequencing with Roche's GS Junior System The Red Cross Blood Transfusion Service of Upper Austria has become the first laboratory in Europe to receive accreditation from the European Federation for Immunogenetics (EFI) for the use of human leukocyte antigen (HLA) tests based on next-generation sequencing with Roche's GS�Junior System. This new method will allow more precise and much more rapid tissue-typing and donor selection for stem cell transplants than has been possible to date...