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Caught In The Act - Protein 'Filmed' While Unfolding At Atomic Resolution
Date: Feb-13-2013By combining low temperatures and NMR spectroscopy, the scientists visualized seven intermediate forms of the CylR2 protein while cooling it down from 25°C to -16°C. Their results show that the most instable intermediate form plays a key role in protein folding. The scientists' findings may contribute to a better understanding of how proteins adopt their structure and misfold during illness. Whether Alzheimer's, Parkinson's or Huntington's Chorea - all three diseases have one thing in common...
Live Surgery Ethics: The Safety Of The Patient Is The Prime Consideration
Date: Feb-13-2013During the final day of the 28th Annual EAU Congress, which will take place on 15-19 March 2013 in Milan, the European Association of Urology will release its official policy statement on live surgery ethics. The statement and accompanying commentary will be delivered by Mr. Keith Parsons (Liverpool, UK), who chairs the EAU Guidelines Office and is a member of the working panel which was tasked with formulating the policy. Chaired by Prof. Walter Artibani, EAU Executive Member Science, the live surgery working panel has been developing the policy since March 2012...
High Lead Exposure May Be Behind Some Juvenile Crime
Date: Feb-13-2013Lead is a common element but is found in old paints (including those once used on children's toys), soil, old piping, water, and the atmosphere from lead-containing vehicular fuels, even drinking vessels. At high dose it is lethal but also causes seemingly trivial symptoms such as headaches. However, in children lead can also lead to irreversible damage to the organs, the kidneys in particular, and the nervous system including the brain. Early detection to contaminated sources is important to prevent children coming to harm but exposure is not always apparent...
Depressive Symptoms In Young Adults May Be Reduced Through Interaction With Avatars
Date: Feb-13-2013Young adults, in a period of transition, are often reluctant to seek treatment for mental health problems because of the stigma, inadequate insurance coverage and difficulty finding a mental health care provider. But a new preliminary study by researchers at Case Western Reserve University suggests that depression symptoms may be significantly reduced when 18- to 25-year-olds interact with computerized avatars - virtual 3D images of a healthcare provider like a nurse practitioner or physician - as a way to rehearse office visits ahead of time and learn self-management skills...
Substance Abuse Rates Higher In Teenagers With ADHD: Large Study
Date: Feb-13-2013A new study published online in the Journal of the American Academy of Child and Adolescent Psychiatry revealed a significantly higher prevalence of substance abuse and cigarette use by adolescents with attention deficit hyperactivity disorder (ADHD) histories than in those without ADHD...
Community Health Workers Improve Diabetes Outcomes And Related Behaviors
Date: Feb-13-2013Researchers who conducted a clinical trial in American Samoa to test whether community health workers could help adults with type 2 diabetes found that the patients who received the intervention were twice as likely to make a clinically meaningful improvement as those who remained with care only in the clinic. The results appear in the journal Diabetes Care. Newly published results from a randomized controlled clinical trial in the Pacific U.S...
Simulations Show How Blood Vessels Regroup After Stroke
Date: Feb-13-2013By thinking of cells as programmable robots, researchers at Rice University hope to someday direct how they grow into the tiny blood vessels that feed the brain and help people regain functions lost to stroke and disease. Rice bioengineer Amina Qutub and her colleagues simulate patterns of microvasculature cell growth and compare the results with real networks grown in their lab. Eventually, they want to develop the ability to control the way these networks develop. The results of a long study are the focus of a new paper in the Journal of Theoretical Biology...
Computer Simulations Set To Save Health Care
Date: Feb-13-2013New research from Indiana University has found that machine learning -- the same computer science discipline that helped create voice recognition systems, self-driving cars and credit card fraud detection systems -- can drastically improve both the cost and quality of health care in the United States...
High Level Of Attachment Anxiety May Lower Immunity, Increase Vulnerability To Illness
Date: Feb-13-2013Concerns and anxieties about one's close relationships appear to function as a chronic stressor that can compromise immunity, according to new research. In the study, researchers asked married couples to complete questionnaires about their relationships and collected saliva and blood samples to test participants' levels of a key stress-related hormone and numbers of certain immune cells. The research focused on attachment anxiety...
New Strategy Identified For Interfering With A Potent Cancer-Causing Gene
Date: Feb-13-2013Acute myeloid leukemia (AML) is an aggressive blood cancer that is currently incurable in 70% of patients. In a bold effort, CSHL scientists are among those identifying and characterizing the molecular mechanisms responsible for this cancer in order to generate potential new therapeutics. CSHL Assistant Professor Christopher Vakoc, M.D., Ph.D., and colleagues, including the group of Professor Robert Roeder Ph.D. at The Rockefeller University, report the characterization of a protein required for AML in a paper published in the Proceedings of the National Academy of Sciences...
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