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Improved Understanding Of How The Bladder Senses Fullness Could Lead To Treatments For Incontinence And Overactive Bladder
Date: Feb-12-2013If you have an overactive bladder or incontinence, help could be on the way. A new research report published online in the The FASEB Journal, shows that the epithelium, a thin layer of cells which line the surface of the bladder, is able to sense how full the bladder is through the action of a family of proteins called integrins. As the bladder becomes full, the cells in the epithelium stretch and become thinner, which activates the integrins to send that information to nerves and other cells in the bladder...
Accumulation Of Excess Protein Linked To Development Of Parkinson's Disease
Date: Feb-12-2013Researchers at the University of California, San Diego School of Medicine say overexpression of a protein called alpha-synuclein appears to disrupt vital recycling processes in neurons, starting with the terminal extensions of neurons and working its way back to the cells' center, with the potential consequence of progressive degeneration and eventual cell death...
Study Identifies Liver Gene That Regulates Cholesterol And Fat Blood Levels
Date: Feb-12-2013Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. This regulator gene controls multiple genes involved in dyslipidemia - abnormal blood cholesterol levels that can contribute to heart disease. Study details published in the February issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD), describe a new in silico approach to identify the significance of microRNAs in regulating disease-related gene pathways...
12 Important Warning Signs Of Complications In Colorectal Surgical Patients Put Forth By A Panel Of Surgical Experts
Date: Feb-12-2013Colorectal surgical patients are often discharged from the hospital with vague guidance on how to recognize complications, but researchers at the Michael DeBakey Veterans Administration (VA) Medical Center and Baylor College of Medicine, Houston, aim to change that scenario. A health services research team convened a panel of surgical experts to develop a list of postoperative complication signs that should prompt colorectal surgical patients to call their surgeons or go to an emergency room...
Researchers Find The Cause Of Age-Related Cognitive Decline
Date: Feb-12-2013Cognitive decline in old age is linked to decreasing production of new neurons. Scientists from the German Cancer Research Center have discovered in mice that significantly more neurons are generated in the brains of older animals if a signaling molecule called Dickkopf-1 is turned off. In tests for spatial orientation and memory, mice in advanced adult age whose Dickkopf gene had been silenced reached an equal mental performance as young animals. The hippocampus - a structure of the brain whose shape resembles that of a seahorse - is also called the "gateway" to memory...
Researchers Looking To Develop New Treatments For IBD With Fewer Side Effects
Date: Feb-12-2013Scientists have long puzzled over why "bad" bacteria such as E. coli can thrive in the guts of those with inflammatory bowel disease (IBD), causing serious diarrhea. Now UC Davis researchers have discovered the answer - one that may be the first step toward finding new and better treatments for IBD. The researchers discovered a biological mechanism by which harmful bacteria grow, edge out beneficial bacteria and damage the gut in IBD. This new understanding, published in the journal Science, may help researchers develop new treatments for IBD with fewer side effects than current therapies...
Hope For Duchenne Muscular Dystrophy Patients Offered By Experimental Gene Therapy Treatment
Date: Feb-12-2013Jacob Rutt is a bright 11-year-old who likes to draw detailed maps in his spare time. But the budding geographer has a hard time with physical skills most children take for granted - running and climbing trees are beyond him, and even walking can be difficult. He was diagnosed with a form of muscular dystrophy known as Duchenne when he was two years old. The disease affects about 1 in 3,500 newborns - mostly boys - worldwide. It usually becomes apparent in early childhood, as weakened skeletal muscles cause delays in milestones such as sitting and walking...
ER Departments Rarely Treat Pregnant Women For Sexually Transmitted Infections
Date: Feb-12-2013Many pregnant women with sexually transmitted infections aren't getting the treatment they need when they visit emergency rooms, according to a new Michigan State University study that highlights a wholly preventable risk to unborn children and raises questions about current medical guidelines. About half of the 735 women with gonorrhea or chlamydia who visited the ERs at three hospitals in Grand Rapids, Mich. from 2008 through 2010 did not get treatment there, despite the availability of effective and relatively inexpensive antibiotics...
New Website Is Hub Of Educational Information On Changing Landscape Of Scientific, Ethical, And Policy Issues On Animal Research
Date: Feb-12-2013The scientific and ethical debate over the use of animals in medical research has raged for years, but perspectives are shifting, viewpoints are becoming more nuanced, and new initiatives are seeking alternatives to animal testing, according to a special report by The Hastings Center, "Animal Research Ethics: Evolving Views and Practices." The report is available on a new Web site*, a hub of educational information that defines and interprets this changing landscape...
Groundbreaking Discovery Of Cell Nucleus Structure Crucial To Understanding Diseases
Date: Feb-12-2013Genes relocated from their correct position in the nucleus cause them to malfunction and this may lead to the heart, blood vessels and muscles breaking down. This new discovery by A*STAR scientists may be the key to finding new cures in the future. Scientists from Singapore and Germany have identified that the proteins lamin A (Lmna) and lamin B receptor (Lbr) are essential for holding silent genes in their correct position at the edge of the nucleus, in the form of heterochromatin[1]...
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