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Low Vitamin D Levels Linked To High Risk Of Premenopausal Breast Cancer
Date: Jan-29-2013A prospective study led by researchers from the University of California, San Diego School of Medicine has found that low serum vitamin D levels in the months preceding diagnosis may predict a high risk of premenopausal breast cancer. The study of blood levels of 1,200 healthy women found that women whose serum vitamin D level was low during the three-month period just before diagnosis had approximately three times the risk of breast cancer as women in the highest vitamin D group...
Hope For New Strategies Against Sepsis
Date: Jan-29-2013Scientists at the Center for Translational Medicine at the Temple University School of Medicine are inching closer to solving a long-standing mystery in sepsis, a complex and often life-threatening condition that affects more than 400,000 people in the U.S. every year. By blocking the activity of a protein, STIM1, in cells that line the insides of blood vessels in mice, they have halted a cascade of cellular events that culminates in the out-of-control inflammation that marks sepsis, and protected lungs from severe damage...
Exploring The Potential Benefits And Threats Of Nanotechnology Research
Date: Jan-29-2013Every day scientists learn more about how the world works at the smallest scales. While this knowledge has the potential to help others, it's possible that the same discoveries can also be used in ways that cause widespread harm. A new article in the journal Nanomedicine, born out of a Federal Bureau of Investigation workshop held at the University of Notre Dame in September 2012, tackles this complex "dual-use" aspect of nanotechnology research...
Stress May Increase Risk For Prostate Cancer
Date: Jan-29-2013Prostate cancer patients have increased levels of stress and anxiety; however, several recent studies have found that men who take drugs that interfere with the stress hormone adrenaline have a lower incidence of prostate cancer. In this issue of the Journal of Clinical Investigation George Kulik and colleagues at Wake Forest University examined the relationship between stress and cancer progression in a mouse model of prostate cancer...
The LINC Complex Is Essential For Hearing
Date: Jan-29-2013In this issue of the Journal of Clinical Investigation, Karen Avraham and colleagues at Tel Aviv University identified a genetic mutation in two families with hereditary high frequency hearing loss. The mutated gene, which has not previously been linked to hearing loss, encodes NESP4, a protein that is expressed in the outer nuclear membrane (ONM) of the hair cells of the ear...
Reducing The Level Of Mutant P53 Gene Increases Susceptibility To Cancer Treatment
Date: Jan-29-2013Scientists from the National Cancer Centre Singapore (NCCS) have discovered the workings of the gene that has been hindering treatment response in cancer patients. This discovery was made after 5 years of studying the mutant form of the p53 gene, the major tumor suppressor in humans, which is generally found mutated in over 50% of all type of human cancers. The dominant-negative (DN) effect of the mutant p53 gene in cancers was found to affect the outcome of cancer treatment modalities...
The Time Has Come To Treat Anemia Seriously
Date: Jan-29-2013Up to one-third of patients undergoing surgery in Ontario have a treatable form of anemia but are not optimally treated for it. A paper published online in the Canadian Journal of Anesthesia says that hospitals that do treat patients with anemia have better outcomes, including fewer blood transfusions and infections and shorter hospital stays. A common option for management of anemia has been blood transfusion. But blood transfusions are expensive and are associated with higher death and complication rates. Dr. Gregory Hare, an anesthesiologist at St...
Computer Scientists Develop New Way To Study Molecular Networks
Date: Jan-29-2013In biology, molecules can have multi-way interactions within cells, and until recently, computational analysis of these links has been "incomplete," according to T. M. Murali, associate professor of computer science in the College of Engineering at Virginia Tech. His group authored an article on their new approach to address these shortcomings, titled "Reverse Engineering Molecular Hypergraphs," that received the Best Paper Award at the recent 2012 ACM Conference on Bioinformatics, Computational Biology and Biomedicine...
Patients With Chronic Ailments Benefit From Medical Cannabis - From Improved Appetite To Pain Relief
Date: Jan-29-2013Though controversial, medical cannabis has been gaining ground as a valid therapy, offering relief to suffers of diseases such as cancer, Post-Traumatic Stress Disorder, ALS and more. The substance is known to soothe severe pain, increase the appetite, and ease insomnia where other common medications fail. In 2009, Zach Klein, a graduate of Tel Aviv University's Department of Film and Television Studies, directed the documentary Prescribed Grass...
New Control On Blood Vessels In Developing Brain Revealed By Chance Finding
Date: Jan-29-2013Zhen Huang freely admits he was not interested in blood vessels four years ago when he was studying brain development in a fetal mouse. Instead, he wanted to see how changing a particular gene in brain cells called glia would affect the growth of neurons. The result was hemorrhage, caused by deteriorating veins and arteries, and it begged for explanation. "It was a surprising finding," says Huang, an assistant professor of neuroscience and neurology at the University of Wisconsin-Madison...
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