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Treatment For OP Poisoning Could Save 200,000 Lives A Year
Date: Jan-15-2013An enzyme treatment which could neutralise the effects of lethal chemicals responsible for the deaths of hundreds of thousands of people across the world has been developed by experts at the University of Sheffield. Organophosphorus agents (OP) are used as pesticides in developing countries and acute poisoning is common because of insufficient control, poor storage, ready availability, and inadequate education amongst farmers...
Fast Food Linked To Asthma And Eczema In Kids
Date: Jan-15-2013Kids who eat fast food three or more times a week are likely to have more severe allergic asthma, rhinitis (hay fever), and eczema. The finding came from new international research and was published in the journal Thorax. Similarly, a previous study demonstrated that the benefits of breastfeeding in preventing asthma are cancelled out by eating fast food once or twice a week. The results of the new study motivated the investigators to believe that a fast food diet may be playing a part in the increase in these conditions...
GSK Announces Regulatory Submission Of Its Type 2 Diabetes Drug Albigultide
Date: Jan-15-2013GlaxoSmithKline has announced a regulatory submission to the U.S. Food and Drug Administration for its type 2 diabetes drug called albigultide. The drug, which is taken once-weekly, is a a glucagon-like peptide-1 agonist (GLP-1 agonist). The peptide GLP-1 promotes insulin production which is vital for stabilizing blood sugar levels after a meal - those with diabetes aren't able to properly secrete this peptide. Normal insulin production is restored among diabetics by taking Albiglutide, which contains two modified human copies of GLP-1 - enabling a longer duration of action...
How A Tadpole's Tail Has Implications For Human Healing
Date: Jan-15-2013Scientists at The University of Manchester have made a surprising finding after studying how tadpoles re-grow their tails which could have big implications for research into human healing and regeneration. It is generally appreciated that frogs and salamanders have remarkable regenerative capacities, in contrast to mammals, including humans. For example, if a tadpole loses its tail a new one will regenerate within a week...
Metabolic Control Of Cancer Suppressor Gene Points To New Cancer Therapeutics, Links Metabolism With Cellular Aging
Date: Jan-15-2013It is perhaps impossible to overstate the importance of the tumor suppressor gene p53. It is the single most frequently mutated gene in human tumors. p53 keeps pre-cancerous cells in check by causing cells, among other things, to become senescent - aging at the cellular level. Loss of p53 causes cells to ignore the cellular signals that would normally make mutant or damaged cells die or stop growing. In short, the p53 pathway is an obvious and attractive target for drug developers...
New Device Uses Graphene Plasmonics To Beat Drug Cheats, Detect Viruses And Much More
Date: Jan-15-2013Writing in Nature Materials, the scientists, working with colleagues from Aix-Marseille University, have created a device which potentially can see one molecule though a simple optical system and can analyse its components within minutes. This uses plasmonics - the study of vibrations of electrons in different materials. The breakthrough could allow for rapid and more accurate drug testing for professional athletes as it could detect the presence of even trace amounts of a substance...
IFIT Antiviral Protein Recognizes Foreign RNA And Blocks Viral Infections
Date: Jan-15-2013Researchers at McGill University and the Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences have discovered the molecular blueprint behind the IFIT protein. This key protein enables the human immune system to detect viruses and prevent infection by acting as foot soldiers guarding the body against infection. They recognize foreign viral ribonucleic acid (RNA) produced by the virus and act as defender molecules by potentially latching onto the genome of the virus and preventing it from making copies of itself, blocking infection...
Why Down Syndrome Increases Susceptibility To Alzheimer's Disease, Diabetes And Autistic Spectrum Disorders
Date: Jan-15-2013A study led by UC Irvine researchers has revealed some of the underlying neural factors that explain why people with Down syndrome are more susceptible to Alzheimer's disease, diabetes and autistic spectrum disorders. Jorge Busciglio, associate professor of neurobiology & behavior, and colleagues analyzed the cellular and molecular mechanisms leading to oxidative stress and mitochondrial dysfunction in Down syndrome individuals. They found that this breakdown in energy metabolism within brain cells contributes to the higher probability of these other conditions...
The Importance Of Fat Location And How Belly Fat Differs From Thigh Fat
Date: Jan-15-2013Researchers discover that the genes active in a person's belly fat are significantly different from those in his or her thigh fat, a finding that could shift the way we approach unwanted belly fat - from banishing it to relocating it. Men tend to store fat in the abdominal area, but don't usually have much in the way of hips or thighs. Women, on the other hand, are more often pear-shaped - storing more fat on their hips and thighs than in the belly. Why are women and men shaped differently? The answer still isn't clear, but it's an issue worth investigating, says Steven Smith, M.D...
Studying Immune Cells In The Search For Therapeutic Targets For Treating Multiple Sclerosis
Date: Jan-15-2013Misguided killer T cells may be the missing link in sustained tissue damage in the brains and spines of people with multiple sclerosis, findings from the University of Washington reveal. Cytoxic T cells, also known as CD8+ T cells, are white blood cells that normally are in the body's arsenal to fight disease. Multiple sclerosis is characterized by inflamed lesions that damage the insulation surrounding nerve fibers and destroy the axons, electrical impulse conductors that look like long, branching projections. Affected nerves fail to transmit signals effectively...
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