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World's First Human Heart Cell Model Developed By National Heart Centre Singapore
Date: Oct-27-2012Researchers at the National Heart Centre Singapore (NHCS) have successfully created a human heart cell model of arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited heart muscle disorder which puts one at high risk of developing life-threatening arrhythmias and sudden cardiac death. The NHCS research team discovered that key characteristics of the disease, such as abnormal "fatty changes" and altered distribution of proteins involved in cell-cell connections (called desmosomal proteins) are reproduced in the heart cells...
Measurable Neurophysiological Effects Produced By Self-Affirmation
Date: Oct-27-2012Life is about failure as much as it is about success. From the mistakes we make at work or school to our blunders in romantic relationships, we are constantly reminded of how we could be better. By focusing on the important qualities that make us who we are - a process called self-affirmation - we preserve our self-worth in the face of our shortcomings...
Phagenesis Launches First Treatment For Acute Dysphagia
Date: Oct-27-2012Phagenesis has launched the world's first approved treatment for acute dysphagia following stroke. The Phagenyx™ system delivers calibrated electrical stimulus to the throat (oropharynx) for 10 minutes a day for three consecutive days to patients who suffer from dysphagia - the inability to swallow safely - a debilitating condition that affects about half of all stroke patients[1]. Randomised controlled clinical trials show that this protocol leads to statistically significant improvements in patients' swallowing function...
Study Suggests Caution And Further Studies On Drugs Used To Treat Macular Degeneration
Date: Oct-27-2012Millions of people with "wet" macular degeneration are prescribed a class of medication known as anti-VEGF drugs. But now scientists at The Scripps Research Institute (TSRI) have found that a drastic reduction of VEGF activity may do more harm than good. In the new study, the researchers deleted the gene for the blood-vessel growth factor VEGF, which has been implicated in stimulating abnormal blood vessel growth in a range of cancers and eye diseases, from cells in the retinas of adult mice...
Pulmonary Embolism Treatment Xarelto® (Rivaroxaban) Recommended For EU Approval
Date: Oct-27-2012Rivaroxaban offers the first oral single-drug solution for the treatment of PE and long-term prevention of DVT and PE. Decision of European Commisson on approval expected before year-end. Bayer HealthCare's oral anticoagulant Xarelto® (rivaroxaban) has been recommended for approval by the European Committee for Medicinal Products for Human Use (CHMP) for the treatment of pulmonary embolism (PE) and the prevention of recurrent deep vein thrombosis (DVT) and PE in adults. The decision of the European Commission on the approval is expected before the year-end...
Researchers Uncover New Target For Cancer Research
Date: Oct-27-2012In a new paper released in Nature, BioFrontiers Institute scientists at the University of Colorado Boulder, Tom Cech and Leslie Leinwand, detailed a new target for anti-cancer drug development that is sitting at the ends of our DNA. Researchers in the two scientists' laboratories collaborated to find a patch of amino acids that, if blocked by a drug docked onto the chromosome end at this location, may prevent cancerous cells from reproducing...
Challenging Parkinson's Dogma
Date: Oct-27-2012Scientists may have discovered why the standard treatment for Parkinson's disease is often effective for only a limited period of time. Their research could lead to a better understanding of many brain disorders, from drug addiction to depression, that share certain signaling molecules involved in modulating brain activity. A team led by Bernardo Sabatini, Takeda Professor of Neurobiology at Harvard Medical School, used mouse models to study dopamine neurons in the striatum, a region of the brain involved in both movement and learning...
The Deadly Secrets Of Pancreatic Cancer
Date: Oct-27-2012A large-scale study that defines the complexity of underlying mutations responsible for pancreatic cancers in more than 100 patients was published in Nature. The analysis represents the first report from Australia's contribution to the International Cancer Genome Consortium (ICGC), which brings together the world's leading scientists to identify the genetic drivers behind 50 different cancer types. Pancreatic cancer has the highest mortality rate of all the major cancers and is one of the few for which survival has not improved substantially over the past 40 years...
Towards A Better Treatment For Head And Neck Cancers?
Date: Oct-27-2012Researchers from the Western Australian Institute for Medical Research (WAIMR) have taken an important step towards improved treatment of head and neck cancers with new work that has been published by the journal PLOS ONE. The researchers, led by Professor Peter Leedman, conducted an in vitro study to explore a potential synergy between a tiny RNA molecule, miR-7, and erlotinib, a drug currently used to treat head and neck cancers...
Research Project Protecting Children From Soil-Transmitted Diseases
Date: Oct-27-2012Almost $1.5 million in funding has been awarded to researchers at The University of Queensland (UQ), who are working to reduce one of the world's most common chronic infections. Dr Darren Gray, from UQ's School of Population Health (SPH), was awarded the National Health and Medical Research Council (NHMRC) funding, to continue his team's research into reducing infection by soil-transmitted helminths (STH) in children in China and the Philippines. More than a third of the world's population is infected with STH, which are the most widespread and disabling chronic infections globally...
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