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Early Childhood Trauma Takes Visible Toll On Brain

Date: Oct-18-2012
Trauma in infancy and childhood shapes the brain, learning, and behavior, and fuels changes that can last a lifetime, according to new human and animal research just released. The studies delve into the effects of early physical abuse, socioeconomic status (SES), and maternal treatment. Documenting the impact of early trauma on brain circuitry and volume, the activation of genes, and working memory, researchers suggest it increases the risk of mental disorders, as well as heart disease and stress-related conditions in adulthood...

How Sickling Cells Make People Sick

Date: Oct-18-2012
Researchers at Drexel University have identified the physical forces in red blood cells and blood vessels underlying the painful symptoms of sickle cell disease. Their experiment, the first to answer a scientific question about sickle cell disease using microfluidics engineering methods, may help future researchers better determine who is at greatest risk of harm from the disease. They report their findings in Cell Press's Biophysical Journal.  Capillary Blockage Conundrum Like many scientific questions, this discovery began with a mystery...

Patient Perspective Is Key To Adequate Evaluation Of Cancer Treatment

Date: Oct-18-2012
Patient-reported outcomes should be a standard part of evaluating the comparative effectiveness of cancer treatments, according to recommendations put forward by a multi-institution research group...

Pilot Study In Neurosurgery Shows Safety And Benefits Of Extradural Stimulation For Parkinson's Disease

Date: Oct-18-2012
Electrical stimulation using extradural electrodes - placed underneath the skull but not implanted in the brain - is a safe approach with meaningful benefits for patients with Parkinson's disease, reports the October issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health...

For Advanced Barrett's Esophagus, Endoscopic Mucosal Resection Before Radiofrequency Ablation Is Equally Effective Compared With RFA Alone

Date: Oct-18-2012
A new study shows that endoscopic mucosal resection (EMR) before radiofrequency ablation (RFA) is a safe and effective treatment option for patients with nodular Barrett's esophagus (BE) and advanced neoplasia. The performance of EMR before RFA was not associated with a diminished likelihood of success of therapy or an increased rate of stricture compared with those with advanced neoplasia undergoing RFA alone. The study appears in the October issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE)...

Higher Nurse Workloads Increase Likelihood Of Death Among Older Surgical Patients

Date: Oct-18-2012
Older black patients are three times more likely than older white patients to suffer poorer outcomes after surgery, including death, when cared for by nurses with higher workloads, reports research from the University of Pennsylvania School of Nursing. The large-scale study showed higher nurse workloads negatively affected older surgical patients generally and that the rate was more significant in older black individuals...

The Effects Of Child Maltreatment May Be Ameliorated In Adulthood By Marriage, Education

Date: Oct-18-2012
Researchers investigating the long-term consequences of child abuse have identified some protective factors that can improve the health of victims during their adulthood. Men and women in their 30s who had been abused or neglected as children reported worse mental and physical health than their non-abused peers. But being married or having graduated from high school buffered the severity of their symptoms...

Obese Children More Likely To Experience Foot, Knee And Hip Pain

Date: Oct-18-2012
Pain in the lower extremities - feet, ankles, knees and hips - contributes to both poor physical function and a reduced quality of life in obese children, according to a new study by Dr. Sharon Bout-Tabaku and colleagues, from Nationwide Children's Hospital and The Ohio State University in the US. Their work shows that obese children with lower extremity pain have worse physical function and poorer psychological health than obese children without lower extremity pain. Their findings appear online in Clinical Orthopaedics and Related Research®, published by Springer...

DNA Damage Response Network Integrates With Other Cell Activities, Opens Door To New Cancer Therapies

Date: Oct-18-2012
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida; Duke University; Johns Hopkins University; the Brazilian National Cancer Institute; and the Rio de Janeiro Federal Institute of Education, Science and Technology have discovered that an intricate system to repair DNA damage called the "DNA damage response" (DDR) contains previously unknown components, including proteins that could be targeted as sensitizers for chemotherapy. Some of these targets may already have drugs available that have unrecognized uses in cancer therapy, said the researchers...

Anti-Cancer Drugs Linked To Muscle Repair By Novel Discovery

Date: Oct-18-2012
Few drugs are available to treat muscle injury, muscle wasting and genetic disorders causing muscle degeneration, such as Duchenne muscular dystrophy. A compelling discovery that may change this was made recently by a research group led by Dr. Robert Korneluk, distinguished professor at University of Ottawa's Faculty of Medicine and founder of the CHEO Research Institute's Apoptosis Research Centre, was reported in Science Signaling. "We know of five pharmaceutical companies pursuing phase one clinical trials with specific drugs to treat cancer patients," says Dr. Korneluk...