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Iron-Sulfur Enzymes As Candidates For Antibiotic Development
Date: Oct-11-2012The iron-sulfur protein IspH plays a central role in the terpene metabolism of several pathogens. The mechanism of the reaction provides an approach for developing new antibiotics, particularly against malaria and tuberculosis. While researching this enzyme, biochemists at the Technische Universitat Munchen (TUM) discovered a previously unknown reaction: IspH accepts two completely different classes of molecules as partners. This surprising insight, published in Nature Communications, opens up new perspectives in combating infectious diseases...
Correct Use Of Car Restraints For Children Would Prevent Many Injuries And Deaths
Date: Oct-11-2012Car accidents are the main cause of serious injury and death among children in Norway. A new study from the Norwegian Institute of Public Health shows that 37 per cent of all children under 16 years are incorrectly restrained in the car. 23 per cent of children are so poorly restrained that a collision would have very serious consequences. The study results were presented at a seminar on traffic accidents in Oslo...
Discovery Of New Biological Pathway May Aid In The Redesign Of Certain Diabetes Drugs To Eliminate Or Reduce Adverse Side Effects
Date: Oct-11-2012Many drugs work by "fixing" a particular biological pathway that's gone awry in a disease. But sometimes drugs affect other pathways too, producing undesirable side effects that can be severe enough to outweigh the drug's benefits. Such is the case for the thiazolidinedione drugs (also known as TZDs), which are used to treat type 2 diabetes. These are highly effective in controlling blood glucose levels and have an added benefit of lowering blood pressure in some patients...
Physical Therapy, Not A Knee Brace, Aids In ACL Recovery
Date: Oct-11-2012Wearing a knee brace following anterior cruciate ligament (ACL) surgery has no effect on a person's recovery. However, strength, range-of- motion, and functionality exercises provide significant benefits, and other new therapies may show promise. In a new literature review recently published in the Journal of Bone and Joint Surgery (JBJS), a team of orthopaedic surgeons reviewed 29 studies regarding treatment following reconstructive ACL surgery. They found that physical therapy, begun shortly after surgery, can bring about very good outcomes for patients...
Biochemists Open Path To Molecular 'Chaperone' Therapy For Metabolic Disease
Date: Oct-11-2012University of Massachusetts Amherst researchers, experts in revealing molecular structure by X-ray crystallography, have identified two new small "chaperone" molecules that may be useful in treating the inherited metabolic disorder known as Schindler/Kanzaki disease. This offers hope for developing the first ever drug treatment for this very rare disease. Findings are reported in the current issue of Proceedings of the National Academy of Sciences...
In Non-Diabetic Kidney Disease Among African-Americans, Non-genetic Factors Play A Role
Date: Oct-11-2012The high rate of non-diabetic kidney disease in African-Americans is strongly associated with variations in a particular gene. Yet, not everyone who inherits these variations develops the disease. Researchers at Wake Forest Baptist Medical Center are working to find out why. In a study published in the October issue of the journal Kidney International, the research team evaluated children and siblings of African-Americans on dialysis to determine why some develop kidney disease and others don't...
Quality Of Patient Care Improved By Electronic Health Records
Date: Oct-11-2012A new study by Weill Cornell Medical College researchers, published in the Journal of General Internal Medicine, provides compelling evidence that electronic health records (EHRs) enhance the quality of patient care in a community-based setting with multiple payers, which is representative of how medicine is generally practiced across the United States. The use of EHRs is on the rise, in part because the federal government has invested up to $29 billion in incentives promoting the meaningful use of these systems, with the aim of tracking and improving patient outcomes...
Renowned Virus Experts Address The Moratorium On Potentially Hazardous H5N1 Influenza Research
Date: Oct-11-2012Last winter, scientists at the University of Wisconsin and Erasmus University (Netherlands) shocked the world by announcing they had developed strains of H5N1 influenza that could easily pass between mammals (ferrets). In nature, H5N1 is extremely lethal (kills nearly 60% of its human cases), but it does not easily spread from person-to-person. Thus, biosafety concerns were raised over the possible release, accidental or intentional, of these new viruses...
New Study Provides Compelling Evidence That Commercially Available Electronic Health Records Are Associated With Better Physician Performance
Date: Oct-11-2012A new study by Weill Cornell Medical College researchers, published in the Journal of General Internal Medicine, provides compelling evidence that electronic health records (EHRs) enhance the quality of patient care in a community-based setting with multiple payers, which is representative of how medicine is generally practiced across the United States. The use of EHRs is on the rise, in part because the federal government has invested up to $29 billion in incentives promoting the meaningful use of these systems, with the aim of tracking and improving patient outcomes...
In Diagnosing Important Cervical Spine Injuries, Canadian C-Spine Rule More Accurate Than Other Rules
Date: Oct-11-2012To screen for cervical spine injuries such as fractures in the emergency department, the Canadian C-spine rule appears to be more accurate compared with NEXUS, another commonly used rule, according to a study in CMAJ (Canadian Medical Association Journal). NEXUS stands for the National Emergency X-Radiography Utilization Study. "In the only direct comparison, the Canadian C-spine rule appeared to have better diagnostic accuracy, and it should be used over NEXUS to assess the need for cervical spine imaging," writes Dr...
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