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Using Lower Doses Of Chemo With Greater Effect: New Hope For Taming Triple-Negative Breast Cancer

Date: Oct-04-2012
Disease-free survival is short-lived for women with triple-negative breast cancer - a form of the disease that doesn't respond to hormone drugs and becomes resistant to chemotherapy. Thankfully, a promising line of study in the School of Medicine at The University of Texas Health Science Center San Antonio suggests it is possible to fine-tune the properties of this fearsome cancer, making it more sensitive to treatment. Once preclinical studies have been completed in coming months, this new approach should be ready to test in female patients, a scientist said...

Association Between Common Heartburn Drugs And Risk Of Pneumonia Questionsed By Study

Date: Oct-04-2012
Previous studies that have associated the use of proton pump inhibitors (PPI) - which include popular anti-heartburn medications like Prilosec and Nexium - with an increased incidence of pneumonia may not have found a true cause-and-effect relationship. A study that has been released online by the Journal of General Internal Medicine outlines a strategy for determining when the results of such observational studies may have been distorted by unmeasured factors and then finds that may be the case with the association between PPIs and pneumonia risk...

New Technologies Advance Livestock Genomics For Agricultural And Biomedical Uses

Date: Oct-04-2012
New genome editing technologies developed at the University of Minnesota for use on livestock will allow scientists to learn more about human diseases. �The genomic technique, known as TALENS, is described in a report published in the scientific journal Proceedings of the National Academy of Science. The technique is cheaper and faster than previous technologies that allow scientists to genetically modify livestock animals; the animals are used to learn more about human diseases, which in turn can help researchers develop cures...

New Colonoscopy Surveillance Guidelines Issued By GI Societies

Date: Oct-04-2012
Patients at average risk of colorectal cancer who have a clean colonoscopy do not need to repeat the test for 10 years. This and many other practical recommendations for cancer prevention were issued in "Guidelines for Colonoscopy Surveillance After Screening and Polypectomy,"1 a consensus update issued by the U.S. Multisociety Task Force on Colorectal Cancer. Colorectal cancer is preventable when precancerous polyps (growths) are found and removed before they turn into cancer...

Improving Stem Cell Transplant Outcomes By Harnessing The Immune System

Date: Oct-04-2012
A novel therapy in the early stages of development at Virginia Commonwealth University Massey Cancer Center shows promise in providing lasting protection against the progression of multiple myeloma following a stem cell transplant by making the cancer cells easier targets for the immune system.  View a short video about this study featuring Toor and several patients who participated in the clinical trial: Outlined in the British Journal of Hematology, the Phase II clinical trial was led by Amir Toor, M.D...

A Biological Effect Of Aging May Be Slowed By Omega-3 Supplements

Date: Oct-04-2012
Taking enough omega-3 fatty acid supplements to change the balance of oils in the diet could slow a key biological process linked to aging, new research suggests. The study showed that most overweight but healthy middle-aged and older adults who took omega-3 supplements for four months altered a ratio of their fatty acid consumption in a way that helped preserve tiny segments of DNA in their white blood cells. These segments, called telomeres, are known to shorten over time in many types of cells as a consequence of aging...

Stroke Evaluation By Smartphone Technology

Date: Oct-04-2012
A new Mayo Clinic study confirms the use of smartphones medical images to evaluate patients in remote locations through telemedicine. The study, the first to test the effectiveness of smartphone teleradiology applications in a real-world telestroke network, was recently published in Stroke, a journal of the American Heart Association. "Essentially what this means is that telemedicine can fit in our pockets," says Bart Demaerschalk, M.D., professor of Neurology, and medical director of Mayo Clinic Telestroke...

Macrophage Accumulation Of Triglycerides Yields Insights Into Atherosclerosis

Date: Oct-04-2012
A research report appearing in the Journal of Leukocyte Biology helps explain how specific immune cells, called macrophages, accumulate triglycerides to support their function. Because a characteristic finding in atherosclerosis is the accumulation of fat in macrophages in the arterial wall, understanding how macrophages accumulate triglycerides may lead to new approaches toward slowing or stopping the development of atherosclerosis...

New Targeted Therapy Indicated By Breakthrough In Understanding Lung Cancer Vulnerabilities

Date: Oct-04-2012
More effective treatments for one of the deadliest forms of cancer are one step closer thanks to groundbreaking research from an international collaborative study. Scientists from the Universities of Sheffield and Cologne have identified the dependencies of multiple Small Cell Lung Cancer (SCLC) types - paving the way for clinical trials of new targeted treatments which could revolutionise the current approach. Around 40,000 people are diagnosed annually with lung cancer in the UK, and SCLC accounts for nearly one in five of all these cases...

Heart Failure May Be Prevented By Popular Antidepressant

Date: Oct-04-2012
A medication usually used to help treat depression and anxiety disorders has the potential to help prevent heart failure, according to researchers at the University of Michigan. John Tesmer, research professor at the U-M Life Sciences Institute and professor in the Department of Pharmacology at the U-M Medical School, and his research team at the Tesmer lab found that paroxetine, a selective serotonin reuptake inhibitor (SSRI) sold under the name Paxil, inhibits G protein-coupled receptor kinase 2 (GRK2), a protein kinase that becomes over-expressed when people have heart failure...