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Collaboration To Accelerate New Tuberculosis Treatments Announced By Sanofi And TB Alliance
Date: Sep-25-2012Sanofi (EURONEXT: SAN and NYSE: SNY) and the Global Alliance for TB Drug Development (TB Alliance) have announced a new research collaboration agreement to accelerate the discovery and development of novel compounds against tuberculosis (TB), a deadly infectious disease that resulted in almost 1.5 million deaths worldwide1 in 2010. Under the agreement, Sanofi and TB Alliance will collaborate to further optimize and develop several novel compounds in Sanofi's library that have demonstrated activity against Mycobacterium tuberculosis, the bacterium that causes TB...
Study Finds Interdisciplinary Approach To Monitoring And Managing Pain Improves Patient Care And Satisfaction
Date: Sep-25-2012Researchers from Mount Sinai School of Medicine have identified reliable predictors of pain by surveying patients throughout their hospital stays about the severity of their pain and their levels of satisfaction with how their pain was managed by hospital staff. Using this data, interdisciplinary teams treating patients were able to identify patients at higher risk for pain prior to, or immediately upon, their admission to the hospital, and create and implement intervention plans resulting in patients reporting lower levels of pain and higher levels of satisfaction with their pain management...
Genetic Features Shared Between Some Deadly Breast Cancers And Ovarian Tumors
Date: Sep-25-2012The most comprehensive analysis yet of breast cancer shows that one of the most deadly subtypes is genetically more similar to ovarian tumors than to other breast cancers. The findings, published online in Nature, suggest that most basal-like breast tumors and ovarian tumors have similar genetic origins and potentially could be treated with the same drugs, says the study's co-leader Matthew J. Ellis, MD, PhD, the Anheuser-Busch Chair in Medical Oncology at Washington University School of Medicine in St. Louis. The other co-leader is Charles M...
Research Reveals Near-Roadway Air Pollution A Major Contributor To Asthma In Los Angeles County
Date: Sep-25-2012Research conducted at the University of Southern California (USC) indicates that at least 8 percent of the more than 300,000 cases of childhood asthma in Los Angeles County can be attributed to traffic-related pollution at homes within 75 meters (a little less than 250 feet) of a busy roadway. The study also indicates that previous estimates of childhood asthma exacerbation related to air pollution may have underestimated the true burden of exposure on society. The research was published online Sept...
Women's Experiences With Chromosome Abnormalities Found In New Prenatal Test
Date: Sep-25-2012We often hear that "knowledge is power." But, that isn't always the case, especially when the knowledge pertains to the health of an unborn child, with murky implications, at best. A new study, led by researchers from the Perelman School of Medicine at the University of Pennsylvania, begins to document this exception to the general rule...
Key To A Cure For HIV May Be Provided By The Addictive Properties Of Certain Drugs
Date: Sep-25-2012A Florida State University researcher is on a mission to explore the gene-controlling effects of addictive drugs in pursuit of new HIV treatments. Working under the support of a $1.8 million grant from the National Institutes of Health (NIH), Florida State biologist Jonathan Dennis is studying a unique ability shared between a promising class of HIV treatments known as histone deacetylase inhibitors (HDIs) and psychostimulant drugs such as cocaine...
Protein Identified That Regulates Key 'Fate' Decision In Cortical Progenitor Cells
Date: Sep-25-2012DOCK7 expression determines if radial glial cells will proliferate or differentiate Researchers at Cold Spring Harbor Laboratory (CSHL) have solved an important piece of one of neuroscience's outstanding puzzles: how progenitor cells in the developing mammalian brain reproduce themselves while also giving birth to neurons that will populate the emerging cerebral cortex, the seat of cognition and executive function in the mature brain. CSHL Professor Linda Van Aelst, Ph.D...
Lysosomal Storage Diseases May Be Treatable With Enzyme Therapeutics From The Greenhouse
Date: Sep-25-2012The seeds of greenhouse-grown corn could hold the key to treating a rare, life-threatening childhood genetic disease, according to researchers from Simon Fraser University. SFU biologist Allison Kermode and her team have been carrying out multidisciplinary research toward developing enzyme therapeutics for lysosomal storage diseases - rare, but devastating childhood genetic diseases - for more than a decade. In the most severe forms of these inherited diseases, untreated patients die in early childhood because of progressive damage to all organs of the body...
Lung Cancer Susceptibility May Depend Upon Key Immune Cell
Date: Sep-25-2012Why do many heavy smokers evade lung cancer while others who have never lit up die of the disease? The question has vexed scientists for decades. Now, new research at Washington University School of Medicine in St. Louis suggests a key immune cell may play a role in lung cancer susceptibility. Working in mice, they found evidence that the genetic diversity in natural killer cells, which typically seek out and destroy tumor cells, contributes to whether or not the animals develop lung cancer. The research is published in September in Cancer Research...
Novel Approach For Single Molecule Electronic DNA Sequencing
Date: Sep-25-2012DNA sequencing is the driving force behind key discoveries in medicine and biology. For instance, the complete sequence of an individual's genome provides important markers and guidelines for medical diagnostics and healthcare. Up to now, the major roadblock has been the cost and speed of obtaining highly accurate DNA sequences. While numerous advances have been made in the last 10 years, most current high-throughput sequencing instruments depend on optical techniques for the detection of the four building blocks of DNA: A, C, G and T...
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